A small-molecule SARS-CoV-2 inhibitor targeting the membrane protein

Ellen Van Damme, Pravien Abeywickrema, Yanting Yin, Jiexiong Xie, Sofie Jacobs, Mandeep Kaur Mann, Jordi Doijen, Robyn Miller, Madison Piassek, Simone Marsili, Murali Subramanian, Leah Gottlieb, Rana Abdelnabi, Michiel Van Gool, Nick Van den Broeck, Ines De Pauw, Annick Diels, Peter Vermeulen, Koen Temmerman, Trevor Scobey, Melissa Mattocks, Alexandra Schäfer, Dirk Jochmans, Steven De Jonghe, Pieter Leyssen, Winston Chiu, Mayra Diosa Toro, Marleen Zwaagstra, Anouk A. Leijs, Heidi L. M. De Gruyter, Christophe Buyck, Klaas Van Den Heede, Frank Jacobs, Christel Van den Eynde, Laura Thijs, Valerie Raeymaekers, Seth Miller, Amanda Del Rosario, Johan Neyts, Danielle Peeters, Ralph S. Baric, Frank J. M. van Kuppeveld, Eric J. Snijder, Martijn J. van Hemert, Mario Monshouwer, Sujata Sharma, Ruxandra Draghia-Akli, Anil Koul, Marnix Van Loock

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DOI: 10.1038/s41586-025-08651-6
Published: 2025-03-26
Container: Nature
Publisher: Springer Science and Business Media LLC
Open access: unknown

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Cite this work

BibTeX

@article{allodium:10.1038/s41586-025-08651-6,
  title = {A small-molecule SARS-CoV-2 inhibitor targeting the membrane protein},
  author = {Ellen Van Damme and Pravien Abeywickrema and Yanting Yin and Jiexiong Xie and Sofie Jacobs and Mandeep Kaur Mann and Jordi Doijen and Robyn Miller and Madison Piassek and Simone Marsili and Murali Subramanian and Leah Gottlieb and Rana Abdelnabi and Michiel Van Gool and Nick Van den Broeck and Ines De Pauw and Annick Diels and Peter Vermeulen and Koen Temmerman and Trevor Scobey and Melissa Mattocks and Alexandra Schäfer and Dirk Jochmans and Steven De Jonghe and Pieter Leyssen and Winston Chiu and Mayra Diosa Toro and Marleen Zwaagstra and Anouk A. Leijs and Heidi L. M. De Gruyter and Christophe Buyck and Klaas Van Den Heede and Frank Jacobs and Christel Van den Eynde and Laura Thijs and Valerie Raeymaekers and Seth Miller and Amanda Del Rosario and Johan Neyts and Danielle Peeters and Ralph S. Baric and Frank J. M. van Kuppeveld and Eric J. Snijder and Martijn J. van Hemert and Mario Monshouwer and Sujata Sharma and Ruxandra Draghia-Akli and Anil Koul and Marnix Van Loock},
  year = {2025},
  journal = {Nature},
  doi = {10.1038/s41586-025-08651-6},
  url = {https://doi.org/10.1038/s41586-025-08651-6}
}

RIS

TY  - JOUR
TI  - A small-molecule SARS-CoV-2 inhibitor targeting the membrane protein
AU  - Ellen Van Damme
AU  - Pravien Abeywickrema
AU  - Yanting Yin
AU  - Jiexiong Xie
AU  - Sofie Jacobs
AU  - Mandeep Kaur Mann
AU  - Jordi Doijen
AU  - Robyn Miller
AU  - Madison Piassek
AU  - Simone Marsili
AU  - Murali Subramanian
AU  - Leah Gottlieb
AU  - Rana Abdelnabi
AU  - Michiel Van Gool
AU  - Nick Van den Broeck
AU  - Ines De Pauw
AU  - Annick Diels
AU  - Peter Vermeulen
AU  - Koen Temmerman
AU  - Trevor Scobey
AU  - Melissa Mattocks
AU  - Alexandra Schäfer
AU  - Dirk Jochmans
AU  - Steven De Jonghe
AU  - Pieter Leyssen
AU  - Winston Chiu
AU  - Mayra Diosa Toro
AU  - Marleen Zwaagstra
AU  - Anouk A. Leijs
AU  - Heidi L. M. De Gruyter
AU  - Christophe Buyck
AU  - Klaas Van Den Heede
AU  - Frank Jacobs
AU  - Christel Van den Eynde
AU  - Laura Thijs
AU  - Valerie Raeymaekers
AU  - Seth Miller
AU  - Amanda Del Rosario
AU  - Johan Neyts
AU  - Danielle Peeters
AU  - Ralph S. Baric
AU  - Frank J. M. van Kuppeveld
AU  - Eric J. Snijder
AU  - Martijn J. van Hemert
AU  - Mario Monshouwer
AU  - Sujata Sharma
AU  - Ruxandra Draghia-Akli
AU  - Anil Koul
AU  - Marnix Van Loock
PY  - 2025
JO  - Nature
DO  - 10.1038/s41586-025-08651-6
UR  - https://doi.org/10.1038/s41586-025-08651-6
ER  -

APA

Damme, E. V., Abeywickrema, P., Yin, Y., Xie, J., Jacobs, S., Mann, M. K., Doijen, J., Miller, R., Piassek, M., Marsili, S., Subramanian, M., Gottlieb, L., Abdelnabi, R., Gool, M. V., Broeck, N. V. D., Pauw, I. D., Diels, A., Vermeulen, P., Temmerman, K., Scobey, T., Mattocks, M., Schäfer, A., Jochmans, D., Jonghe, S. D., Leyssen, P., Chiu, W., Toro, M. D., Zwaagstra, M., Leijs, A. A., Gruyter, H. L. M. D., Buyck, C., Heede, K. V. D., Jacobs, F., Eynde, C. V. D., Thijs, L., Raeymaekers, V., Miller, S., Rosario, A. D., Neyts, J., Peeters, D., Baric, R. S., Kuppeveld, F. J. M. V., Snijder, E. J., Hemert, M. J. V., Monshouwer, M., Sharma, S., Draghia-Akli, R., Koul, A., & Loock, M. V. (2025). A small-molecule SARS-CoV-2 inhibitor targeting the membrane protein. Nature. https://doi.org/10.1038/s41586-025-08651-6

Source records

crossref · retrieved 2026-09-26T03:04:28.643Z