Single-cell atlas of transcriptomic vulnerability across brain disorders

Donghoon Lee, Mikaela Koutrouli, Nicolas Y. Masse, Gabriel E. Hoffman, Seon Kinrot, Xinyi Wang, Prashant N. M., Milos Pjanic, Tereza Clarence, Fotios Tsetsos, Deepika Mathur, David Burstein, Karen Therrien, Aram Hong, Clara Casey, Zhiping Shao, Marcela Alvia, Stathis Argyriou, Jennifer Monteiro Fortes, Sarah R. Murphy, Pavel Katsel, Pavan K. Auluck, Lisa L. Barnes, Stefano Marenco, David A. Bennett, Unknown, Athan Z. Li, Biao Zeng, Chenfeng He, Chirag Gupta, Christian Dillard, Christian Porras, Colleen A. McClung, Collin Spencer, Daifeng Wang, Gennadi Ryan, Hui Yang, Jerome J. Choi, Kalpana H. Arachchilage, Lars J. Jensen, Logan C. Dumitrescu, Lyra Sheu, Madeline R. Scott, Marios Anyfantakis, Maxim Signaevsky, Monika Ahirwar, Noah Cohen Kalafut, Pengfei Dong, Pramod B. Chandrashekar, Rachel Bercovitch, Roman Kosoy, Sanan Venkatesh, Saniya Khullar, Sayali A. Alatkar, Steven Finkbeiner, Steven P. Kleopoulos, Timothy J. Hohman, Ting Jin, Vivek G. Ramaswamy, Xiang Huang, Zhenyi Wu, Lars Juhl Jensen, Kiran Girdhar, Georgios Voloudakis, Vahram Haroutunian, Jaroslav Bendl, John F. Fullard, Panos Roussos

Open source

DOI
10.1038/s41586-025-09573-z
Published
2026-09-23
Container
Nature
Publisher
Springer Science and Business Media LLC
Open access
unknown

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BibTeX

@article{allodium:10.1038/s41586-025-09573-z,
  title = {Single-cell atlas of transcriptomic vulnerability across brain disorders},
  author = {Donghoon Lee and Mikaela Koutrouli and Nicolas Y. Masse and Gabriel E. Hoffman and Seon Kinrot and Xinyi Wang and Prashant N. M. and Milos Pjanic and Tereza Clarence and Fotios Tsetsos and Deepika Mathur and David Burstein and Karen Therrien and Aram Hong and Clara Casey and Zhiping Shao and Marcela Alvia and Stathis Argyriou and Jennifer Monteiro Fortes and Sarah R. Murphy and Pavel Katsel and Pavan K. Auluck and Lisa L. Barnes and Stefano Marenco and David A. Bennett and Unknown and Athan Z. Li and Biao Zeng and Chenfeng He and Chirag Gupta and Christian Dillard and Christian Porras and Colleen A. McClung and Collin Spencer and Daifeng Wang and Gennadi Ryan and Hui Yang and Jerome J. Choi and Kalpana H. Arachchilage and Lars J. Jensen and Logan C. Dumitrescu and Lyra Sheu and Madeline R. Scott and Marios Anyfantakis and Maxim Signaevsky and Monika Ahirwar and Noah Cohen Kalafut and Pengfei Dong and Pramod B. Chandrashekar and Rachel Bercovitch and Roman Kosoy and Sanan Venkatesh and Saniya Khullar and Sayali A. Alatkar and Steven Finkbeiner and Steven P. Kleopoulos and Timothy J. Hohman and Ting Jin and Vivek G. Ramaswamy and Xiang Huang and Zhenyi Wu and Lars Juhl Jensen and Kiran Girdhar and Georgios Voloudakis and Vahram Haroutunian and Jaroslav Bendl and John F. Fullard and Panos Roussos},
  year = {2026},
  journal = {Nature},
  doi = {10.1038/s41586-025-09573-z},
  url = {https://doi.org/10.1038/s41586-025-09573-z}
}

RIS

TY  - JOUR
TI  - Single-cell atlas of transcriptomic vulnerability across brain disorders
AU  - Donghoon Lee
AU  - Mikaela Koutrouli
AU  - Nicolas Y. Masse
AU  - Gabriel E. Hoffman
AU  - Seon Kinrot
AU  - Xinyi Wang
AU  - Prashant N. M.
AU  - Milos Pjanic
AU  - Tereza Clarence
AU  - Fotios Tsetsos
AU  - Deepika Mathur
AU  - David Burstein
AU  - Karen Therrien
AU  - Aram Hong
AU  - Clara Casey
AU  - Zhiping Shao
AU  - Marcela Alvia
AU  - Stathis Argyriou
AU  - Jennifer Monteiro Fortes
AU  - Sarah R. Murphy
AU  - Pavel Katsel
AU  - Pavan K. Auluck
AU  - Lisa L. Barnes
AU  - Stefano Marenco
AU  - David A. Bennett
AU  - Unknown
AU  - Athan Z. Li
AU  - Biao Zeng
AU  - Chenfeng He
AU  - Chirag Gupta
AU  - Christian Dillard
AU  - Christian Porras
AU  - Colleen A. McClung
AU  - Collin Spencer
AU  - Daifeng Wang
AU  - Gennadi Ryan
AU  - Hui Yang
AU  - Jerome J. Choi
AU  - Kalpana H. Arachchilage
AU  - Lars J. Jensen
AU  - Logan C. Dumitrescu
AU  - Lyra Sheu
AU  - Madeline R. Scott
AU  - Marios Anyfantakis
AU  - Maxim Signaevsky
AU  - Monika Ahirwar
AU  - Noah Cohen Kalafut
AU  - Pengfei Dong
AU  - Pramod B. Chandrashekar
AU  - Rachel Bercovitch
AU  - Roman Kosoy
AU  - Sanan Venkatesh
AU  - Saniya Khullar
AU  - Sayali A. Alatkar
AU  - Steven Finkbeiner
AU  - Steven P. Kleopoulos
AU  - Timothy J. Hohman
AU  - Ting Jin
AU  - Vivek G. Ramaswamy
AU  - Xiang Huang
AU  - Zhenyi Wu
AU  - Lars Juhl Jensen
AU  - Kiran Girdhar
AU  - Georgios Voloudakis
AU  - Vahram Haroutunian
AU  - Jaroslav Bendl
AU  - John F. Fullard
AU  - Panos Roussos
PY  - 2026
JO  - Nature
DO  - 10.1038/s41586-025-09573-z
UR  - https://doi.org/10.1038/s41586-025-09573-z
ER  -

APA

Lee, D., Koutrouli, M., Masse, N. Y., Hoffman, G. E., Kinrot, S., Wang, X., M., P. N., Pjanic, M., Clarence, T., Tsetsos, F., Mathur, D., Burstein, D., Therrien, K., Hong, A., Casey, C., Shao, Z., Alvia, M., Argyriou, S., Fortes, J. M., Murphy, S. R., Katsel, P., Auluck, P. K., Barnes, L. L., Marenco, S., Bennett, D. A., Unknown, Li, A. Z., Zeng, B., He, C., Gupta, C., Dillard, C., Porras, C., McClung, C. A., Spencer, C., Wang, D., Ryan, G., Yang, H., Choi, J. J., Arachchilage, K. H., Jensen, L. J., Dumitrescu, L. C., Sheu, L., Scott, M. R., Anyfantakis, M., Signaevsky, M., Ahirwar, M., Kalafut, N. C., Dong, P., Chandrashekar, P. B., Bercovitch, R., Kosoy, R., Venkatesh, S., Khullar, S., Alatkar, S. A., Finkbeiner, S., Kleopoulos, S. P., Hohman, T. J., Jin, T., Ramaswamy, V. G., Huang, X., Wu, Z., Jensen, L. J., Girdhar, K., Voloudakis, G., Haroutunian, V., Bendl, J., Fullard, J. F., & Roussos, P. (2026). Single-cell atlas of transcriptomic vulnerability across brain disorders. Nature. https://doi.org/10.1038/s41586-025-09573-z

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