GLP-1R-GIPR-PPARα/γ/δ quintuple agonism corrects obesity and diabetes in mice.

Liskiewicz D, Novikoff A, Khalil A, Akindehin S, Campbell JE, Candela P, Castelino RL, Coupland C, Culot M, Dodson WS, Douros JD, Embring H, Feuchtinger A, Finan B, Garcia-Caceres C, Gao XB, Gosselet F, Grandl G, Gutgesell RM, Haas DT, Jastroch M, Karaoglu E, Kakimoto P, Kaltenbach AC, Keuper M, Kusminski CM, Leander DC, Liskiewicz A, Liu X, Maity-Kumar G, Martinez SM, Mowery SA, Nogueiras R, Paisley M, Perez-Tilve D, Petersen PSS, Pfluger PT, Prakash S, Steffens S, Cebrian-Serrano A, Tost M, Wean J, Weber C, Yoshida J, Gerhart-Hines Z, Horvath TL, Scherer PE, Seeley RJ, DiMarchi RD, Tschöp MH, Krahmer N, Knerr PJ, Müller TD

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DOI
10.1038/s41586-026-10427-5
Published
2026 May
Container
Nature
Publisher
Not recorded
Open access
yes

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BibTeX

@article{allodium:10.1038/s41586-026-10427-5,
  title = {GLP-1R-GIPR-PPARα/γ/δ quintuple agonism corrects obesity and diabetes in mice.},
  author = {Liskiewicz D and Novikoff A and Khalil A and Akindehin S and Campbell JE and Candela P and Castelino RL and Coupland C and Culot M and Dodson WS and Douros JD and Embring H and Feuchtinger A and Finan B and Garcia-Caceres C and Gao XB and Gosselet F and Grandl G and Gutgesell RM and Haas DT and Jastroch M and Karaoglu E and Kakimoto P and Kaltenbach AC and Keuper M and Kusminski CM and Leander DC and Liskiewicz A and Liu X and Maity-Kumar G and Martinez SM and Mowery SA and Nogueiras R and Paisley M and Perez-Tilve D and Petersen PSS and Pfluger PT and Prakash S and Steffens S and Cebrian-Serrano A and Tost M and Wean J and Weber C and Yoshida J and Gerhart-Hines Z and Horvath TL and Scherer PE and Seeley RJ and DiMarchi RD and Tschöp MH and Krahmer N and Knerr PJ and Müller TD},
  year = {2026},
  journal = {Nature},
  doi = {10.1038/s41586-026-10427-5},
  url = {https://doi.org/10.1038/s41586-026-10427-5}
}

RIS

TY  - JOUR
TI  - GLP-1R-GIPR-PPARα/γ/δ quintuple agonism corrects obesity and diabetes in mice.
AU  - Liskiewicz D
AU  - Novikoff A
AU  - Khalil A
AU  - Akindehin S
AU  - Campbell JE
AU  - Candela P
AU  - Castelino RL
AU  - Coupland C
AU  - Culot M
AU  - Dodson WS
AU  - Douros JD
AU  - Embring H
AU  - Feuchtinger A
AU  - Finan B
AU  - Garcia-Caceres C
AU  - Gao XB
AU  - Gosselet F
AU  - Grandl G
AU  - Gutgesell RM
AU  - Haas DT
AU  - Jastroch M
AU  - Karaoglu E
AU  - Kakimoto P
AU  - Kaltenbach AC
AU  - Keuper M
AU  - Kusminski CM
AU  - Leander DC
AU  - Liskiewicz A
AU  - Liu X
AU  - Maity-Kumar G
AU  - Martinez SM
AU  - Mowery SA
AU  - Nogueiras R
AU  - Paisley M
AU  - Perez-Tilve D
AU  - Petersen PSS
AU  - Pfluger PT
AU  - Prakash S
AU  - Steffens S
AU  - Cebrian-Serrano A
AU  - Tost M
AU  - Wean J
AU  - Weber C
AU  - Yoshida J
AU  - Gerhart-Hines Z
AU  - Horvath TL
AU  - Scherer PE
AU  - Seeley RJ
AU  - DiMarchi RD
AU  - Tschöp MH
AU  - Krahmer N
AU  - Knerr PJ
AU  - Müller TD
PY  - 2026
JO  - Nature
DO  - 10.1038/s41586-026-10427-5
UR  - https://doi.org/10.1038/s41586-026-10427-5
ER  -

APA

D, L., A, N., A, K., S, A., JE, C., P, C., RL, C., C, C., M, C., WS, D., JD, D., H, E., A, F., B, F., C, G., XB, G., F, G., G, G., RM, G., DT, H., M, J., E, K., P, K., AC, K., M, K., CM, K., DC, L., A, L., X, L., G, M., SM, M., SA, M., R, N., M, P., D, P., PSS, P., PT, P., S, P., S, S., A, C., M, T., J, W., C, W., J, Y., Z, G., TL, H., PE, S., RJ, S., RD, D., MH, T., N, K., PJ, K., & TD, M. (2026). GLP-1R-GIPR-PPARα/γ/δ quintuple agonism corrects obesity and diabetes in mice.. Nature. https://doi.org/10.1038/s41586-026-10427-5

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