Single-nucleus multimodal spatial transcriptomics reveals spatial colocalization of neoantigen-expressing tumor cells and cognate T cells.

Nagler A, Sud A, Ghannam JY, Pomerance L, Robles-Oteiza C, Afeyan AB, Weir JA, Russell AJC, Lu WS, Van Orden M, Sonnenholzner A, Marrero GJ, Gong Q, Kumar V, Huang K, Tu C, Lin E, Shim B, De Oliveira GR, Sellars MC, Yoon CH, Reardon DA, Choueiri TK, Olsen LR, Signoretti S, Ott PA, Braun DA, Oliveira G, Li S, Livak KJ, Hacohen N, Chen F, Wu CJ

Open source

DOI: 10.1038/s41587-026-03194-1
Published: 2026 Jul 22
Container: Nature biotechnology
Publisher: Not recorded
Open access: no

Credibility signals

limited evidence Score 43/100 under policy 1.0.0. This is a metadata assessment, not a judgment of the paper's conclusions.

Show all credibility signals

cautionDOI registered: No matching Crossref record was present in this response. Source: Crossref; license: CC0 metadata
cautionDOI resolves: No matching Crossref record was present in this response. Source: Crossref; license: CC0 metadata
not scoredDirectory of Open Access Journals: No matching DOAJ record was present in this response. No allow-list match; this is not evidence of low credibility. Source: DOAJ; license: CC0
not scoredMEDLINE indexed: Not checked or no result supplied; no credibility inference made. Source: No authority result supplied; license: Unknown
not scoredOpenAlex core source: Not checked or no result supplied; no credibility inference made. Source: No authority result supplied; license: Unknown
not scoredKnown publisher allow-list: Not checked or no result supplied; no credibility inference made. Source: No authority result supplied; license: Unknown
not scoredROR affiliation: Not checked or no result supplied; no credibility inference made. Source: No authority result supplied; license: Unknown
not scoredRetraction Watch retraction: No retraction notice matched this DOI in the deployed snapshot. No matching event found; coverage may be incomplete. Source: Retraction Watch; license: CC BY 4.0
not scoredRetraction Watch expression of concern: No expression of concern notice matched this DOI in the deployed snapshot. No matching event found; coverage may be incomplete. Source: Retraction Watch; license: CC BY 4.0
not scoredRetraction Watch correction: No correction notice matched this DOI in the deployed snapshot. No matching event found; coverage may be incomplete. Source: Retraction Watch; license: CC BY 4.0
not scoredRetraction Watch reinstatement: No reinstatement notice matched this DOI in the deployed snapshot. No matching event found; coverage may be incomplete. Source: Retraction Watch; license: CC BY 4.0
not scoredOpen access status: Not checked or no result supplied; no credibility inference made. Source: No authority result supplied; license: Unknown
not scoredPublication license: Not checked or no result supplied; no credibility inference made. Source: No authority result supplied; license: Unknown
not scoredPublication version: A publication version was supplied but is not scored. Source: Normalized work metadata; license: Caller-provided; provenance license not supplied to scorer
cautionMetadata completeness: 5 of 6 scored descriptive metadata groups are present; missing fields increase uncertainty. Source: Normalized work metadata; license: Caller-provided; provenance license not supplied to scorer

Cite this work

BibTeX

@article{allodium:10.1038/s41587-026-03194-1,
  title = {Single-nucleus multimodal spatial transcriptomics reveals spatial colocalization of neoantigen-expressing tumor cells and cognate T cells.},
  author = {Nagler A and Sud A and Ghannam JY and Pomerance L and Robles-Oteiza C and Afeyan AB and Weir JA and Russell AJC and Lu WS and Van Orden M and Sonnenholzner A and Marrero GJ and Gong Q and Kumar V and Huang K and Tu C and Lin E and Shim B and De Oliveira GR and Sellars MC and Yoon CH and Reardon DA and Choueiri TK and Olsen LR and Signoretti S and Ott PA and Braun DA and Oliveira G and Li S and Livak KJ and Hacohen N and Chen F and Wu CJ},
  year = {2026},
  journal = {Nature biotechnology},
  doi = {10.1038/s41587-026-03194-1},
  url = {https://doi.org/10.1038/s41587-026-03194-1}
}

RIS

TY  - JOUR
TI  - Single-nucleus multimodal spatial transcriptomics reveals spatial colocalization of neoantigen-expressing tumor cells and cognate T cells.
AU  - Nagler A
AU  - Sud A
AU  - Ghannam JY
AU  - Pomerance L
AU  - Robles-Oteiza C
AU  - Afeyan AB
AU  - Weir JA
AU  - Russell AJC
AU  - Lu WS
AU  - Van Orden M
AU  - Sonnenholzner A
AU  - Marrero GJ
AU  - Gong Q
AU  - Kumar V
AU  - Huang K
AU  - Tu C
AU  - Lin E
AU  - Shim B
AU  - De Oliveira GR
AU  - Sellars MC
AU  - Yoon CH
AU  - Reardon DA
AU  - Choueiri TK
AU  - Olsen LR
AU  - Signoretti S
AU  - Ott PA
AU  - Braun DA
AU  - Oliveira G
AU  - Li S
AU  - Livak KJ
AU  - Hacohen N
AU  - Chen F
AU  - Wu CJ
PY  - 2026
JO  - Nature biotechnology
DO  - 10.1038/s41587-026-03194-1
UR  - https://doi.org/10.1038/s41587-026-03194-1
ER  -

APA

A, N., A, S., JY, G., L, P., C, R., AB, A., JA, W., AJC, R., WS, L., M, V. O., A, S., GJ, M., Q, G., V, K., K, H., C, T., E, L., B, S., GR, D. O., MC, S., CH, Y., DA, R., TK, C., LR, O., S, S., PA, O., DA, B., G, O., S, L., KJ, L., N, H., F, C., & CJ, W. (2026). Single-nucleus multimodal spatial transcriptomics reveals spatial colocalization of neoantigen-expressing tumor cells and cognate T cells.. Nature biotechnology. https://doi.org/10.1038/s41587-026-03194-1

Source records

pubmed · retrieved 2026-09-25T22:08:54.955Z
europe-pmc · retrieved 2026-09-25T22:08:54.975Z