A blinded, prospective benchmark of in silico antibody discovery anchored to experimental affinity and developability.

Erasmus MF, Bedinger D, Hopkins E, Ferguson G, Strickler J, Graff CP, Summers SR, Capehart SL, Slocum JD, Richardson C, Kumar S, Sun Z, Shang Y, Zhang J, Gu M, Yi L, Wellner A, Zheng S, Lu W, Sormanni P, Greenig M, Zhang H, Mann BT, Baghbanzadeh M, Rahnavard A, Moore GL, Sun H, Ding Y, Nisthal A, Kanodia J, Bernett MJ, Pélissier A, Shao Y, Rodriguez Martinez M, Ramesh K, Nastri H, Evers A, Abdelatif A, Bordner AJ, Bordyuh M, Heo L, Kidd BA, Serhat Tetikol H, Wei S, Shin JE, Peckner R, Manley L, Lunge A, Devasurmutt Y, Guloglu B, Copoiu L, McGibbon M, Fernandez-Quintero ML, Mishra N, Callaghan SM, Swanson OM, Bader DLV, Ferguson JA, Raghavan SSR, Nemoz B, Maillie CA, Bowman C, Briney B, Ward AB, Marcatili P, Akbar R, He B, Wu F, Yao J, Hu B, Kucer M, Gibson KR, Somasundaram R, Hung LW, Kaszuba T, Fremont DH, Jeong H, Kurella VB, Malhotra S, Kumar S, Liu Y, Xu L, Misa J, John ANS, Vogt J, Dávila-Hernández FA, Xu D, Chungyoun M, Huggan ZD, Gray JJ, Parkinson J, Ko YS, Wang W, Geiger F, Ziegler JD, Haas N, Challacombe C, Qamar A, Singh A, Tang YC, An Z, Jiang X, Kim Y, Zhao X, Swanson E, Klattig J, Winkler K, Bataa T, Sandig V, Denzler L, Liu C, Brezski RJ, Spector L, Perea-Schmittle K, D'Angelo S, Ferrara F, Bradbury ARM

Open source

DOI: 10.1038/s41587-026-03238-6
Published: 2026 Aug 19
Container: Nature biotechnology
Publisher: Not recorded
Open access: unknown

Credibility signals

limited evidence Score 43/100 under policy 1.0.0. This is a metadata assessment, not a judgment of the paper's conclusions.

Show all credibility signals

cautionDOI registered: No matching Crossref record was present in this response. Source: Crossref; license: CC0 metadata
cautionDOI resolves: No matching Crossref record was present in this response. Source: Crossref; license: CC0 metadata
not scoredDirectory of Open Access Journals: No matching DOAJ record was present in this response. No allow-list match; this is not evidence of low credibility. Source: DOAJ; license: CC0
not scoredMEDLINE indexed: Not checked or no result supplied; no credibility inference made. Source: No authority result supplied; license: Unknown
not scoredOpenAlex core source: Not checked or no result supplied; no credibility inference made. Source: No authority result supplied; license: Unknown
not scoredKnown publisher allow-list: Not checked or no result supplied; no credibility inference made. Source: No authority result supplied; license: Unknown
not scoredROR affiliation: Not checked or no result supplied; no credibility inference made. Source: No authority result supplied; license: Unknown
not scoredRetraction Watch retraction: No retraction notice matched this DOI in the deployed snapshot. No matching event found; coverage may be incomplete. Source: Retraction Watch; license: CC BY 4.0
not scoredRetraction Watch expression of concern: No expression of concern notice matched this DOI in the deployed snapshot. No matching event found; coverage may be incomplete. Source: Retraction Watch; license: CC BY 4.0
not scoredRetraction Watch correction: No correction notice matched this DOI in the deployed snapshot. No matching event found; coverage may be incomplete. Source: Retraction Watch; license: CC BY 4.0
not scoredRetraction Watch reinstatement: No reinstatement notice matched this DOI in the deployed snapshot. No matching event found; coverage may be incomplete. Source: Retraction Watch; license: CC BY 4.0
not scoredOpen access status: Not checked or no result supplied; no credibility inference made. Source: No authority result supplied; license: Unknown
not scoredPublication license: Not checked or no result supplied; no credibility inference made. Source: No authority result supplied; license: Unknown
not scoredPublication version: A publication version was supplied but is not scored. Source: Normalized work metadata; license: Caller-provided; provenance license not supplied to scorer
cautionMetadata completeness: 5 of 6 scored descriptive metadata groups are present; missing fields increase uncertainty. Source: Normalized work metadata; license: Caller-provided; provenance license not supplied to scorer

Cite this work

BibTeX

@article{allodium:10.1038/s41587-026-03238-6,
  title = {A blinded, prospective benchmark of in silico antibody discovery anchored to experimental affinity and developability.},
  author = {Erasmus MF and Bedinger D and Hopkins E and Ferguson G and Strickler J and Graff CP and Summers SR and Capehart SL and Slocum JD and Richardson C and Kumar S and Sun Z and Shang Y and Zhang J and Gu M and Yi L and Wellner A and Zheng S and Lu W and Sormanni P and Greenig M and Zhang H and Mann BT and Baghbanzadeh M and Rahnavard A and Moore GL and Sun H and Ding Y and Nisthal A and Kanodia J and Bernett MJ and Pélissier A and Shao Y and Rodriguez Martinez M and Ramesh K and Nastri H and Evers A and Abdelatif A and Bordner AJ and Bordyuh M and Heo L and Kidd BA and Serhat Tetikol H and Wei S and Shin JE and Peckner R and Manley L and Lunge A and Devasurmutt Y and Guloglu B and Copoiu L and McGibbon M and Fernandez-Quintero ML and Mishra N and Callaghan SM and Swanson OM and Bader DLV and Ferguson JA and Raghavan SSR and Nemoz B and Maillie CA and Bowman C and Briney B and Ward AB and Marcatili P and Akbar R and He B and Wu F and Yao J and Hu B and Kucer M and Gibson KR and Somasundaram R and Hung LW and Kaszuba T and Fremont DH and Jeong H and Kurella VB and Malhotra S and Kumar S and Liu Y and Xu L and Misa J and John ANS and Vogt J and Dávila-Hernández FA and Xu D and Chungyoun M and Huggan ZD and Gray JJ and Parkinson J and Ko YS and Wang W and Geiger F and Ziegler JD and Haas N and Challacombe C and Qamar A and Singh A and Tang YC and An Z and Jiang X and Kim Y and Zhao X and Swanson E and Klattig J and Winkler K and Bataa T and Sandig V and Denzler L and Liu C and Brezski RJ and Spector L and Perea-Schmittle K and D'Angelo S and Ferrara F and Bradbury ARM},
  year = {2026},
  journal = {Nature biotechnology},
  doi = {10.1038/s41587-026-03238-6},
  url = {https://doi.org/10.1038/s41587-026-03238-6}
}

RIS

TY  - JOUR
TI  - A blinded, prospective benchmark of in silico antibody discovery anchored to experimental affinity and developability.
AU  - Erasmus MF
AU  - Bedinger D
AU  - Hopkins E
AU  - Ferguson G
AU  - Strickler J
AU  - Graff CP
AU  - Summers SR
AU  - Capehart SL
AU  - Slocum JD
AU  - Richardson C
AU  - Kumar S
AU  - Sun Z
AU  - Shang Y
AU  - Zhang J
AU  - Gu M
AU  - Yi L
AU  - Wellner A
AU  - Zheng S
AU  - Lu W
AU  - Sormanni P
AU  - Greenig M
AU  - Zhang H
AU  - Mann BT
AU  - Baghbanzadeh M
AU  - Rahnavard A
AU  - Moore GL
AU  - Sun H
AU  - Ding Y
AU  - Nisthal A
AU  - Kanodia J
AU  - Bernett MJ
AU  - Pélissier A
AU  - Shao Y
AU  - Rodriguez Martinez M
AU  - Ramesh K
AU  - Nastri H
AU  - Evers A
AU  - Abdelatif A
AU  - Bordner AJ
AU  - Bordyuh M
AU  - Heo L
AU  - Kidd BA
AU  - Serhat Tetikol H
AU  - Wei S
AU  - Shin JE
AU  - Peckner R
AU  - Manley L
AU  - Lunge A
AU  - Devasurmutt Y
AU  - Guloglu B
AU  - Copoiu L
AU  - McGibbon M
AU  - Fernandez-Quintero ML
AU  - Mishra N
AU  - Callaghan SM
AU  - Swanson OM
AU  - Bader DLV
AU  - Ferguson JA
AU  - Raghavan SSR
AU  - Nemoz B
AU  - Maillie CA
AU  - Bowman C
AU  - Briney B
AU  - Ward AB
AU  - Marcatili P
AU  - Akbar R
AU  - He B
AU  - Wu F
AU  - Yao J
AU  - Hu B
AU  - Kucer M
AU  - Gibson KR
AU  - Somasundaram R
AU  - Hung LW
AU  - Kaszuba T
AU  - Fremont DH
AU  - Jeong H
AU  - Kurella VB
AU  - Malhotra S
AU  - Kumar S
AU  - Liu Y
AU  - Xu L
AU  - Misa J
AU  - John ANS
AU  - Vogt J
AU  - Dávila-Hernández FA
AU  - Xu D
AU  - Chungyoun M
AU  - Huggan ZD
AU  - Gray JJ
AU  - Parkinson J
AU  - Ko YS
AU  - Wang W
AU  - Geiger F
AU  - Ziegler JD
AU  - Haas N
AU  - Challacombe C
AU  - Qamar A
AU  - Singh A
AU  - Tang YC
AU  - An Z
AU  - Jiang X
AU  - Kim Y
AU  - Zhao X
AU  - Swanson E
AU  - Klattig J
AU  - Winkler K
AU  - Bataa T
AU  - Sandig V
AU  - Denzler L
AU  - Liu C
AU  - Brezski RJ
AU  - Spector L
AU  - Perea-Schmittle K
AU  - D'Angelo S
AU  - Ferrara F
AU  - Bradbury ARM
PY  - 2026
JO  - Nature biotechnology
DO  - 10.1038/s41587-026-03238-6
UR  - https://doi.org/10.1038/s41587-026-03238-6
ER  -

APA

MF, E., D, B., E, H., G, F., J, S., CP, G., SR, S., SL, C., JD, S., C, R., S, K., Z, S., Y, S., J, Z., M, G., L, Y., A, W., S, Z., W, L., P, S., M, G., H, Z., BT, M., M, B., A, R., GL, M., H, S., Y, D., A, N., J, K., MJ, B., A, P., Y, S., M, R. M., K, R., H, N., A, E., A, A., AJ, B., M, B., L, H., BA, K., H, S. T., S, W., JE, S., R, P., L, M., A, L., Y, D., B, G., L, C., M, M., ML, F., N, M., SM, C., OM, S., DLV, B., JA, F., SSR, R., B, N., CA, M., C, B., B, B., AB, W., P, M., R, A., B, H., F, W., J, Y., B, H., M, K., KR, G., R, S., LW, H., T, K., DH, F., H, J., VB, K., S, M., S, K., Y, L., L, X., J, M., ANS, J., J, V., FA, D., D, X., M, C., ZD, H., JJ, G., J, P., YS, K., W, W., F, G., JD, Z., N, H., C, C., A, Q., A, S., YC, T., Z, A., X, J., Y, K., X, Z., E, S., J, K., K, W., T, B., V, S., L, D., C, L., RJ, B., L, S., K, P., S, D., F, F., & ARM, B. (2026). A blinded, prospective benchmark of in silico antibody discovery anchored to experimental affinity and developability.. Nature biotechnology. https://doi.org/10.1038/s41587-026-03238-6

Source records

pubmed · retrieved 2026-09-26T03:56:57.485Z