Chromothripsis-associated chromosome 21 amplification orchestrates transformation to blast-phase MPN through targetable overexpression of DYRK1A

Charlotte K. Brierley, Bon Ham Yip, Giulia Orlando, Jeremy Wen, Sean Wen, Harsh Goyal, Max Levine, G. Maria Jakobsdottir, Avraam Tapinos, Alex J. Cornish, Antonio Rodriguez-Romera, Alba Rodriguez-Meira, Matthew Bashton, Angela Hamblin, Sally Ann Clark, Joseph C. Hamley, Olivia Fox, Madalina Giurgiu, Jennifer O’Sullivan, Lauren Murphy, Assunta Adamo, Aude Anais Olijnik, Anitria Cotton, Emily Hendrix, Shilpa Narina, Shondra M. Pruett-Miller, Amir Enshaei, Claire Harrison, Mark Drummond, Steven Knapper, Ayalew Tefferi, Iléana Antony-Debré, James Davies, Anton G. Henssen, Supat Thongjuea, David C. Wedge, Stefan N. Constantinescu, Elli Papaemmanuil, Bethan Psaila, John D. Crispino, Adam J. Mead

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DOI: 10.1038/s41588-025-02190-6
Published: 2025-06
Container: Nature Genetics
Publisher: Springer Science and Business Media LLC
Open access: unknown

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Cite this work

BibTeX

@article{allodium:10.1038/s41588-025-02190-6,
  title = {Chromothripsis-associated chromosome 21 amplification orchestrates transformation to blast-phase MPN through targetable overexpression of DYRK1A},
  author = {Charlotte K. Brierley and Bon Ham Yip and Giulia Orlando and Jeremy Wen and Sean Wen and Harsh Goyal and Max Levine and G. Maria Jakobsdottir and Avraam Tapinos and Alex J. Cornish and Antonio Rodriguez-Romera and Alba Rodriguez-Meira and Matthew Bashton and Angela Hamblin and Sally Ann Clark and Joseph C. Hamley and Olivia Fox and Madalina Giurgiu and Jennifer O’Sullivan and Lauren Murphy and Assunta Adamo and Aude Anais Olijnik and Anitria Cotton and Emily Hendrix and Shilpa Narina and Shondra M. Pruett-Miller and Amir Enshaei and Claire Harrison and Mark Drummond and Steven Knapper and Ayalew Tefferi and Iléana Antony-Debré and James Davies and Anton G. Henssen and Supat Thongjuea and David C. Wedge and Stefan N. Constantinescu and Elli Papaemmanuil and Bethan Psaila and John D. Crispino and Adam J. Mead},
  year = {2025},
  journal = {Nature Genetics},
  doi = {10.1038/s41588-025-02190-6},
  url = {https://doi.org/10.1038/s41588-025-02190-6}
}

RIS

TY  - JOUR
TI  - Chromothripsis-associated chromosome 21 amplification orchestrates transformation to blast-phase MPN through targetable overexpression of DYRK1A
AU  - Charlotte K. Brierley
AU  - Bon Ham Yip
AU  - Giulia Orlando
AU  - Jeremy Wen
AU  - Sean Wen
AU  - Harsh Goyal
AU  - Max Levine
AU  - G. Maria Jakobsdottir
AU  - Avraam Tapinos
AU  - Alex J. Cornish
AU  - Antonio Rodriguez-Romera
AU  - Alba Rodriguez-Meira
AU  - Matthew Bashton
AU  - Angela Hamblin
AU  - Sally Ann Clark
AU  - Joseph C. Hamley
AU  - Olivia Fox
AU  - Madalina Giurgiu
AU  - Jennifer O’Sullivan
AU  - Lauren Murphy
AU  - Assunta Adamo
AU  - Aude Anais Olijnik
AU  - Anitria Cotton
AU  - Emily Hendrix
AU  - Shilpa Narina
AU  - Shondra M. Pruett-Miller
AU  - Amir Enshaei
AU  - Claire Harrison
AU  - Mark Drummond
AU  - Steven Knapper
AU  - Ayalew Tefferi
AU  - Iléana Antony-Debré
AU  - James Davies
AU  - Anton G. Henssen
AU  - Supat Thongjuea
AU  - David C. Wedge
AU  - Stefan N. Constantinescu
AU  - Elli Papaemmanuil
AU  - Bethan Psaila
AU  - John D. Crispino
AU  - Adam J. Mead
PY  - 2025
JO  - Nature Genetics
DO  - 10.1038/s41588-025-02190-6
UR  - https://doi.org/10.1038/s41588-025-02190-6
ER  -

APA

Brierley, C. K., Yip, B. H., Orlando, G., Wen, J., Wen, S., Goyal, H., Levine, M., Jakobsdottir, G. M., Tapinos, A., Cornish, A. J., Rodriguez-Romera, A., Rodriguez-Meira, A., Bashton, M., Hamblin, A., Clark, S. A., Hamley, J. C., Fox, O., Giurgiu, M., O’Sullivan, J., Murphy, L., Adamo, A., Olijnik, A. A., Cotton, A., Hendrix, E., Narina, S., Pruett-Miller, S. M., Enshaei, A., Harrison, C., Drummond, M., Knapper, S., Tefferi, A., Antony-Debré, I., Davies, J., Henssen, A. G., Thongjuea, S., Wedge, D. C., Constantinescu, S. N., Papaemmanuil, E., Psaila, B., Crispino, J. D., & Mead, A. J. (2025). Chromothripsis-associated chromosome 21 amplification orchestrates transformation to blast-phase MPN through targetable overexpression of DYRK1A. Nature Genetics. https://doi.org/10.1038/s41588-025-02190-6

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crossref · retrieved 2026-09-26T05:52:37.239Z