A blended genome and exome sequencing method captures genetic variation in an unbiased and cost-effective manner

Toni A. Boltz, Benjamin B. Chu, Matthew DeFelice, Calwing Liao, Julia M. Sealock, Robert Ye, Jacqueline I. Goldstein, Lerato Majara, Jack M. Fu, Susan K. Service, Lingyu Zhan, Sarah E. Medland, Sinéad B. Chapman, Simone Rubinacci, Jonna L. Grimsby, Tamrat Abebe, Melkam Alemayehu, Fred K. Ashaba, Elizabeth G. Atkinson, Tim B. Bigdeli, Amanda B. Bradway, Harrison Brand, Lori B. Chibnik, Samuel DeLuca, Ana M. Diaz-Zuluaga, Abebaw Fekadu, Michael Gatzen, Bizu Gelaye, Stella Gichuru, Marissa L. Gildea, Toni C. Hill, Hailiang Huang, Kalyn M. Hubbard, Wilfred E. Injera, Roxanne James, Moses Joloba, Christopher Kachulis, Phillip R. Kalmbach, Rogers Kamulegeya, Gabriel Kigen, Soyeon Kim, Nastassja Koen, Edith K. Kwobah, Joseph Kyebuzibwa, Seungmo Lee, Niall J. Lennon, Penelope A. Lind, Esteban A. Lopera-Maya, Johnstone Makale, Serghei Mangul, Justin McMahon, Pierre Mowlem, Henry Musinguzi, Rehema M. Mwema, Noeline Nakasujja, Carter P. Newman, Lethukuthula L. Nkambule, Conor R. O’Neil, Ana Maria Olivares, Catherine M. Olsen, Linnet Ongeri, Sophie J. Parsa, Adele Pretorius, Shengying Qin, Raj Ramesar, Faye L. Reagan, Chiara Sabatti, Jacquelyn A. Schneider, Welelta Shiferaw, Christine Stevens, Anne Stevenson, Erik Stricker, Rocky E. Stroud, Jessie Tang, Megan Townsend, David Whiteman, Mary T. Yohannes, Mingrui Yu, Kai Yuan, Unknown, Dickens Akena, Lukoye Atwoli, Symon M. Kariuki, Karestan C. Koenen, Charles R. J. C. Newton, Dan J. Stein, Solomon Teferra, Zukiswa Zingela, Carlos N. Pato, Michele T. Pato, Carlos Lopez-Jaramillo, Nelson B. Freimer, Roel A. Ophoff, Loes M. Olde Loohuis, Michael E. Talkowski, Benjamin M. Neale, Daniel P. Howrigan, Alicia R. Martin

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DOI: 10.1038/s41588-026-02669-w
Published: 2026-07-08
Container: Nature Genetics
Publisher: Springer Science and Business Media LLC
Open access: unknown

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Cite this work

BibTeX

@article{allodium:10.1038/s41588-026-02669-w,
title = {A blended genome and exome sequencing method captures genetic variation in an unbiased and cost-effective manner},
author = {Toni A. Boltz and Benjamin B. Chu and Matthew DeFelice and Calwing Liao and Julia M. Sealock and Robert Ye and Jacqueline I. Goldstein and Lerato Majara and Jack M. Fu and Susan K. Service and Lingyu Zhan and Sarah E. Medland and Sinéad B. Chapman and Simone Rubinacci and Jonna L. Grimsby and Tamrat Abebe and Melkam Alemayehu and Fred K. Ashaba and Elizabeth G. Atkinson and Tim B. Bigdeli and Amanda B. Bradway and Harrison Brand and Lori B. Chibnik and Samuel DeLuca and Ana M. Diaz-Zuluaga and Abebaw Fekadu and Michael Gatzen and Bizu Gelaye and Stella Gichuru and Marissa L. Gildea and Toni C. Hill and Hailiang Huang and Kalyn M. Hubbard and Wilfred E. Injera and Roxanne James and Moses Joloba and Christopher Kachulis and Phillip R. Kalmbach and Rogers Kamulegeya and Gabriel Kigen and Soyeon Kim and Nastassja Koen and Edith K. Kwobah and Joseph Kyebuzibwa and Seungmo Lee and Niall J. Lennon and Penelope A. Lind and Esteban A. Lopera-Maya and Johnstone Makale and Serghei Mangul and Justin McMahon and Pierre Mowlem and Henry Musinguzi and Rehema M. Mwema and Noeline Nakasujja and Carter P. Newman and Lethukuthula L. Nkambule and Conor R. O’Neil and Ana Maria Olivares and Catherine M. Olsen and Linnet Ongeri and Sophie J. Parsa and Adele Pretorius and Shengying Qin and Raj Ramesar and Faye L. Reagan and Chiara Sabatti and Jacquelyn A. Schneider and Welelta Shiferaw and Christine Stevens and Anne Stevenson and Erik Stricker and Rocky E. Stroud and Jessie Tang and Megan Townsend and David Whiteman and Mary T. Yohannes and Mingrui Yu and Kai Yuan and Unknown and Dickens Akena and Lukoye Atwoli and Symon M. Kariuki and Karestan C. Koenen and Charles R. J. C. Newton and Dan J. Stein and Solomon Teferra and Zukiswa Zingela and Carlos N. Pato and Michele T. Pato and Carlos Lopez-Jaramillo and Nelson B. Freimer and Roel A. Ophoff and Loes M. Olde Loohuis and Michael E. Talkowski and Benjamin M. Neale and Daniel P. Howrigan and Alicia R. Martin},
year = {2026},
journal = {Nature Genetics},
doi = {10.1038/s41588-026-02669-w},
url = {https://doi.org/10.1038/s41588-026-02669-w}
}

RIS

TY  - JOUR
TI  - A blended genome and exome sequencing method captures genetic variation in an unbiased and cost-effective manner
AU  - Toni A. Boltz
AU  - Benjamin B. Chu
AU  - Matthew DeFelice
AU  - Calwing Liao
AU  - Julia M. Sealock
AU  - Robert Ye
AU  - Jacqueline I. Goldstein
AU  - Lerato Majara
AU  - Jack M. Fu
AU  - Susan K. Service
AU  - Lingyu Zhan
AU  - Sarah E. Medland
AU  - Sinéad B. Chapman
AU  - Simone Rubinacci
AU  - Jonna L. Grimsby
AU  - Tamrat Abebe
AU  - Melkam Alemayehu
AU  - Fred K. Ashaba
AU  - Elizabeth G. Atkinson
AU  - Tim B. Bigdeli
AU  - Amanda B. Bradway
AU  - Harrison Brand
AU  - Lori B. Chibnik
AU  - Samuel DeLuca
AU  - Ana M. Diaz-Zuluaga
AU  - Abebaw Fekadu
AU  - Michael Gatzen
AU  - Bizu Gelaye
AU  - Stella Gichuru
AU  - Marissa L. Gildea
AU  - Toni C. Hill
AU  - Hailiang Huang
AU  - Kalyn M. Hubbard
AU  - Wilfred E. Injera
AU  - Roxanne James
AU  - Moses Joloba
AU  - Christopher Kachulis
AU  - Phillip R. Kalmbach
AU  - Rogers Kamulegeya
AU  - Gabriel Kigen
AU  - Soyeon Kim
AU  - Nastassja Koen
AU  - Edith K. Kwobah
AU  - Joseph Kyebuzibwa
AU  - Seungmo Lee
AU  - Niall J. Lennon
AU  - Penelope A. Lind
AU  - Esteban A. Lopera-Maya
AU  - Johnstone Makale
AU  - Serghei Mangul
AU  - Justin McMahon
AU  - Pierre Mowlem
AU  - Henry Musinguzi
AU  - Rehema M. Mwema
AU  - Noeline Nakasujja
AU  - Carter P. Newman
AU  - Lethukuthula L. Nkambule
AU  - Conor R. O’Neil
AU  - Ana Maria Olivares
AU  - Catherine M. Olsen
AU  - Linnet Ongeri
AU  - Sophie J. Parsa
AU  - Adele Pretorius
AU  - Shengying Qin
AU  - Raj Ramesar
AU  - Faye L. Reagan
AU  - Chiara Sabatti
AU  - Jacquelyn A. Schneider
AU  - Welelta Shiferaw
AU  - Christine Stevens
AU  - Anne Stevenson
AU  - Erik Stricker
AU  - Rocky E. Stroud
AU  - Jessie Tang
AU  - Megan Townsend
AU  - David Whiteman
AU  - Mary T. Yohannes
AU  - Mingrui Yu
AU  - Kai Yuan
AU  - Unknown
AU  - Dickens Akena
AU  - Lukoye Atwoli
AU  - Symon M. Kariuki
AU  - Karestan C. Koenen
AU  - Charles R. J. C. Newton
AU  - Dan J. Stein
AU  - Solomon Teferra
AU  - Zukiswa Zingela
AU  - Carlos N. Pato
AU  - Michele T. Pato
AU  - Carlos Lopez-Jaramillo
AU  - Nelson B. Freimer
AU  - Roel A. Ophoff
AU  - Loes M. Olde Loohuis
AU  - Michael E. Talkowski
AU  - Benjamin M. Neale
AU  - Daniel P. Howrigan
AU  - Alicia R. Martin
PY  - 2026
JO  - Nature Genetics
DO  - 10.1038/s41588-026-02669-w
UR  - https://doi.org/10.1038/s41588-026-02669-w
ER  -

APA

Boltz, T. A., Chu, B. B., DeFelice, M., Liao, C., Sealock, J. M., Ye, R., Goldstein, J. I., Majara, L., Fu, J. M., Service, S. K., Zhan, L., Medland, S. E., Chapman, S. B., Rubinacci, S., Grimsby, J. L., Abebe, T., Alemayehu, M., Ashaba, F. K., Atkinson, E. G., Bigdeli, T. B., Bradway, A. B., Brand, H., Chibnik, L. B., DeLuca, S., Diaz-Zuluaga, A. M., Fekadu, A., Gatzen, M., Gelaye, B., Gichuru, S., Gildea, M. L., Hill, T. C., Huang, H., Hubbard, K. M., Injera, W. E., James, R., Joloba, M., Kachulis, C., Kalmbach, P. R., Kamulegeya, R., Kigen, G., Kim, S., Koen, N., Kwobah, E. K., Kyebuzibwa, J., Lee, S., Lennon, N. J., Lind, P. A., Lopera-Maya, E. A., Makale, J., Mangul, S., McMahon, J., Mowlem, P., Musinguzi, H., Mwema, R. M., Nakasujja, N., Newman, C. P., Nkambule, L. L., O’Neil, C. R., Olivares, A. M., Olsen, C. M., Ongeri, L., Parsa, S. J., Pretorius, A., Qin, S., Ramesar, R., Reagan, F. L., Sabatti, C., Schneider, J. A., Shiferaw, W., Stevens, C., Stevenson, A., Stricker, E., Stroud, R. E., Tang, J., Townsend, M., Whiteman, D., Yohannes, M. T., Yu, M., Yuan, K., Unknown, Akena, D., Atwoli, L., Kariuki, S. M., Koenen, K. C., Newton, C. R. J. C., Stein, D. J., Teferra, S., Zingela, Z., Pato, C. N., Pato, M. T., Lopez-Jaramillo, C., Freimer, N. B., Ophoff, R. A., Loohuis, L. M. O., Talkowski, M. E., Neale, B. M., Howrigan, D. P., & Martin, A. R. (2026). A blended genome and exome sequencing method captures genetic variation in an unbiased and cost-effective manner. Nature Genetics. https://doi.org/10.1038/s41588-026-02669-w

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crossref · retrieved 2026-09-26T07:13:57.252Z