Population-scale single-nucleus multi-omic profiling of skeletal muscle reveals extensive context-specific genetic regulation.

Varshney A, Manickam N, Orchard P, Tovar A, Ventresca C, Zhang Z, Feng F, Mears J, Erdos MR, Narisu N, Nishino K, Rai V, Stringham HM, Jackson AU, Tamsen T, Gao C, Yang M, Koues OI, Welch JD, Burant CF, Williams LK, Jenkinson C, DeFronzo RA, Norton L, Saramies J, Lakka TA, Laakso M, Tuomilehto J, Mohlke KL, Kitzman JO, Koistinen HA, Liu J, Boehnke M, Collins FS, Scott LJ, Parker SCJ

Open source

DOI: 10.1038/s41588-026-02786-6
Published: 2026 Oct 28
Container: Nature genetics
Publisher: Not recorded
Open access: no

Credibility signals

limited evidence Score 43/100 under policy 1.0.0. This is a metadata assessment, not a judgment of the paper's conclusions.

Show all credibility signals

cautionDOI registered: No matching Crossref record was present in this response. Source: Crossref; license: CC0 metadata
cautionDOI resolves: No matching Crossref record was present in this response. Source: Crossref; license: CC0 metadata
not scoredDirectory of Open Access Journals: No matching DOAJ record was present in this response. No allow-list match; this is not evidence of low credibility. Source: DOAJ; license: CC0
not scoredMEDLINE indexed: Not checked or no result supplied; no credibility inference made. Source: No authority result supplied; license: Unknown
not scoredOpenAlex core source: Not checked or no result supplied; no credibility inference made. Source: No authority result supplied; license: Unknown
not scoredKnown publisher allow-list: Not checked or no result supplied; no credibility inference made. Source: No authority result supplied; license: Unknown
not scoredROR affiliation: Not checked or no result supplied; no credibility inference made. Source: No authority result supplied; license: Unknown
not scoredRetraction Watch retraction: No retraction notice matched this DOI in the deployed snapshot. No matching event found; coverage may be incomplete. Source: Retraction Watch; license: CC BY 4.0
not scoredRetraction Watch expression of concern: No expression of concern notice matched this DOI in the deployed snapshot. No matching event found; coverage may be incomplete. Source: Retraction Watch; license: CC BY 4.0
not scoredRetraction Watch correction: No correction notice matched this DOI in the deployed snapshot. No matching event found; coverage may be incomplete. Source: Retraction Watch; license: CC BY 4.0
not scoredRetraction Watch reinstatement: No reinstatement notice matched this DOI in the deployed snapshot. No matching event found; coverage may be incomplete. Source: Retraction Watch; license: CC BY 4.0
not scoredOpen access status: Not checked or no result supplied; no credibility inference made. Source: No authority result supplied; license: Unknown
not scoredPublication license: Not checked or no result supplied; no credibility inference made. Source: No authority result supplied; license: Unknown
not scoredPublication version: A publication version was supplied but is not scored. Source: Normalized work metadata; license: Caller-provided; provenance license not supplied to scorer
cautionMetadata completeness: 5 of 6 scored descriptive metadata groups are present; missing fields increase uncertainty. Source: Normalized work metadata; license: Caller-provided; provenance license not supplied to scorer

Cite this work

BibTeX

@article{allodium:10.1038/s41588-026-02786-6,
  title = {Population-scale single-nucleus multi-omic profiling of skeletal muscle reveals extensive context-specific genetic regulation.},
  author = {Varshney A and Manickam N and Orchard P and Tovar A and Ventresca C and Zhang Z and Feng F and Mears J and Erdos MR and Narisu N and Nishino K and Rai V and Stringham HM and Jackson AU and Tamsen T and Gao C and Yang M and Koues OI and Welch JD and Burant CF and Williams LK and Jenkinson C and DeFronzo RA and Norton L and Saramies J and Lakka TA and Laakso M and Tuomilehto J and Mohlke KL and Kitzman JO and Koistinen HA and Liu J and Boehnke M and Collins FS and Scott LJ and Parker SCJ},
  year = {2026},
  journal = {Nature genetics},
  doi = {10.1038/s41588-026-02786-6},
  url = {https://doi.org/10.1038/s41588-026-02786-6}
}

RIS

TY  - JOUR
TI  - Population-scale single-nucleus multi-omic profiling of skeletal muscle reveals extensive context-specific genetic regulation.
AU  - Varshney A
AU  - Manickam N
AU  - Orchard P
AU  - Tovar A
AU  - Ventresca C
AU  - Zhang Z
AU  - Feng F
AU  - Mears J
AU  - Erdos MR
AU  - Narisu N
AU  - Nishino K
AU  - Rai V
AU  - Stringham HM
AU  - Jackson AU
AU  - Tamsen T
AU  - Gao C
AU  - Yang M
AU  - Koues OI
AU  - Welch JD
AU  - Burant CF
AU  - Williams LK
AU  - Jenkinson C
AU  - DeFronzo RA
AU  - Norton L
AU  - Saramies J
AU  - Lakka TA
AU  - Laakso M
AU  - Tuomilehto J
AU  - Mohlke KL
AU  - Kitzman JO
AU  - Koistinen HA
AU  - Liu J
AU  - Boehnke M
AU  - Collins FS
AU  - Scott LJ
AU  - Parker SCJ
PY  - 2026
JO  - Nature genetics
DO  - 10.1038/s41588-026-02786-6
UR  - https://doi.org/10.1038/s41588-026-02786-6
ER  -

APA

A, V., N, M., P, O., A, T., C, V., Z, Z., F, F., J, M., MR, E., N, N., K, N., V, R., HM, S., AU, J., T, T., C, G., M, Y., OI, K., JD, W., CF, B., LK, W., C, J., RA, D., L, N., J, S., TA, L., M, L., J, T., KL, M., JO, K., HA, K., J, L., M, B., FS, C., LJ, S., & SCJ, P. (2026). Population-scale single-nucleus multi-omic profiling of skeletal muscle reveals extensive context-specific genetic regulation.. Nature genetics. https://doi.org/10.1038/s41588-026-02786-6

Source records

pubmed · retrieved 2026-11-11T01:26:06.871Z
europe-pmc · retrieved 2026-11-11T01:26:06.894Z