Hypoxia induces histone clipping and H3K4me3 loss in neutrophil progenitors resulting in long-term impairment of neutrophil immunity.

Sanchez-Garcia MA, Sadiku P, Ortmann BM, Wit N, Negishi Y, Coelho P, Zhang A, Pednekar C, Howden AJM, Griffith DM, Seear R, Kindrick JD, Mengede J, Cooper G, Morrison T, Watts ER, Shimeld BT, Reyes L, Mirchandani AS, Arienti S, Xu X, Thomson A, Brenes AJ, Turton HA, Dowey R, Hull RC, Davidson-Smith H, McLaren A, Deans A, Choudhury G, Doverman K, Hope D, Vick O, Woodhead A, Petrie I, Green S, Rzechorzek NM, Turtle L, Openshaw PJM, Semple MG, PHOSP-COVID Study Collaborative Group, Sproul D, Baillie JK, Thompson AAR, Mole DR, von Kriegsheim A, Whyte MKB, Mhlanga MM, Nathan JA, Walmsley SR

Open source

DOI
10.1038/s41590-025-02301-9
Published
2025 Nov
Container
Nature immunology
Publisher
Not recorded
Open access
yes

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BibTeX

@article{allodium:10.1038/s41590-025-02301-9,
  title = {Hypoxia induces histone clipping and H3K4me3 loss in neutrophil progenitors resulting in long-term impairment of neutrophil immunity.},
  author = {Sanchez-Garcia MA and Sadiku P and Ortmann BM and Wit N and Negishi Y and Coelho P and Zhang A and Pednekar C and Howden AJM and Griffith DM and Seear R and Kindrick JD and Mengede J and Cooper G and Morrison T and Watts ER and Shimeld BT and Reyes L and Mirchandani AS and Arienti S and Xu X and Thomson A and Brenes AJ and Turton HA and Dowey R and Hull RC and Davidson-Smith H and McLaren A and Deans A and Choudhury G and Doverman K and Hope D and Vick O and Woodhead A and Petrie I and Green S and Rzechorzek NM and Turtle L and Openshaw PJM and Semple MG and PHOSP-COVID Study Collaborative Group and Sproul D and Baillie JK and Thompson AAR and Mole DR and von Kriegsheim A and Whyte MKB and Mhlanga MM and Nathan JA and Walmsley SR},
  year = {2025},
  journal = {Nature immunology},
  doi = {10.1038/s41590-025-02301-9},
  url = {https://doi.org/10.1038/s41590-025-02301-9}
}

RIS

TY  - JOUR
TI  - Hypoxia induces histone clipping and H3K4me3 loss in neutrophil progenitors resulting in long-term impairment of neutrophil immunity.
AU  - Sanchez-Garcia MA
AU  - Sadiku P
AU  - Ortmann BM
AU  - Wit N
AU  - Negishi Y
AU  - Coelho P
AU  - Zhang A
AU  - Pednekar C
AU  - Howden AJM
AU  - Griffith DM
AU  - Seear R
AU  - Kindrick JD
AU  - Mengede J
AU  - Cooper G
AU  - Morrison T
AU  - Watts ER
AU  - Shimeld BT
AU  - Reyes L
AU  - Mirchandani AS
AU  - Arienti S
AU  - Xu X
AU  - Thomson A
AU  - Brenes AJ
AU  - Turton HA
AU  - Dowey R
AU  - Hull RC
AU  - Davidson-Smith H
AU  - McLaren A
AU  - Deans A
AU  - Choudhury G
AU  - Doverman K
AU  - Hope D
AU  - Vick O
AU  - Woodhead A
AU  - Petrie I
AU  - Green S
AU  - Rzechorzek NM
AU  - Turtle L
AU  - Openshaw PJM
AU  - Semple MG
AU  - PHOSP-COVID Study Collaborative Group
AU  - Sproul D
AU  - Baillie JK
AU  - Thompson AAR
AU  - Mole DR
AU  - von Kriegsheim A
AU  - Whyte MKB
AU  - Mhlanga MM
AU  - Nathan JA
AU  - Walmsley SR
PY  - 2025
JO  - Nature immunology
DO  - 10.1038/s41590-025-02301-9
UR  - https://doi.org/10.1038/s41590-025-02301-9
ER  -

APA

MA, S., P, S., BM, O., N, W., Y, N., P, C., A, Z., C, P., AJM, H., DM, G., R, S., JD, K., J, M., G, C., T, M., ER, W., BT, S., L, R., AS, M., S, A., X, X., A, T., AJ, B., HA, T., R, D., RC, H., H, D., A, M., A, D., G, C., K, D., D, H., O, V., A, W., I, P., S, G., NM, R., L, T., PJM, O., MG, S., Group, P. S. C., D, S., JK, B., AAR, T., DR, M., A, V. K., MKB, W., MM, M., JA, N., & SR, W. (2025). Hypoxia induces histone clipping and H3K4me3 loss in neutrophil progenitors resulting in long-term impairment of neutrophil immunity.. Nature immunology. https://doi.org/10.1038/s41590-025-02301-9

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