Senolytics improve physical function and increase lifespan in old age.

Xu M, Pirtskhalava T, Farr JN, Weigand BM, Palmer AK, Weivoda MM, Inman CL, Ogrodnik MB, Hachfeld CM, Fraser DG, Onken JL, Johnson KO, Verzosa GC, Langhi LGP, Weigl M, Giorgadze N, LeBrasseur NK, Miller JD, Jurk D, Singh RJ, Allison DB, Ejima K, Hubbard GB, Ikeno Y, Cubro H, Garovic VD, Hou X, Weroha SJ, Robbins PD, Niedernhofer LJ, Khosla S, Tchkonia T, Kirkland JL

Open source

DOI: 10.1038/s41591-018-0092-9
Published: 2018 Aug
Container: Nature medicine
Publisher: Not recorded
Open access: yes

Credibility signals

limited evidence Score 45/100 under policy 1.0.0. This is a metadata assessment, not a judgment of the paper's conclusions.

Show all credibility signals

cautionDOI registered: No matching Crossref record was present in this response. Source: Crossref; license: CC0 metadata
cautionDOI resolves: No matching Crossref record was present in this response. Source: Crossref; license: CC0 metadata
not scoredDirectory of Open Access Journals: No matching DOAJ record was present in this response. No allow-list match; this is not evidence of low credibility. Source: DOAJ; license: CC0
not scoredMEDLINE indexed: Not checked or no result supplied; no credibility inference made. Source: No authority result supplied; license: Unknown
not scoredOpenAlex core source: Not checked or no result supplied; no credibility inference made. Source: No authority result supplied; license: Unknown
not scoredKnown publisher allow-list: Not checked or no result supplied; no credibility inference made. Source: No authority result supplied; license: Unknown
not scoredROR affiliation: Not checked or no result supplied; no credibility inference made. Source: No authority result supplied; license: Unknown
not scoredRetraction Watch retraction: No retraction notice matched this DOI in the deployed snapshot. No matching event found; coverage may be incomplete. Source: Retraction Watch; license: CC BY 4.0
not scoredRetraction Watch expression of concern: No expression of concern notice matched this DOI in the deployed snapshot. No matching event found; coverage may be incomplete. Source: Retraction Watch; license: CC BY 4.0
not scoredRetraction Watch correction: No correction notice matched this DOI in the deployed snapshot. No matching event found; coverage may be incomplete. Source: Retraction Watch; license: CC BY 4.0
not scoredRetraction Watch reinstatement: No reinstatement notice matched this DOI in the deployed snapshot. No matching event found; coverage may be incomplete. Source: Retraction Watch; license: CC BY 4.0
supportingOpen access status: Normalized open-access status: open. Source: Normalized work metadata; license: Caller-provided; provenance license not supplied to scorer
not scoredPublication license: Not checked or no result supplied; no credibility inference made. Source: No authority result supplied; license: Unknown
not scoredPublication version: A publication version was supplied but is not scored. Source: Normalized work metadata; license: Caller-provided; provenance license not supplied to scorer
cautionMetadata completeness: 5 of 6 scored descriptive metadata groups are present; missing fields increase uncertainty. Source: Normalized work metadata; license: Caller-provided; provenance license not supplied to scorer

Cite this work

BibTeX

@article{allodium:10.1038/s41591-018-0092-9,
  title = {Senolytics improve physical function and increase lifespan in old age.},
  author = {Xu M and Pirtskhalava T and Farr JN and Weigand BM and Palmer AK and Weivoda MM and Inman CL and Ogrodnik MB and Hachfeld CM and Fraser DG and Onken JL and Johnson KO and Verzosa GC and Langhi LGP and Weigl M and Giorgadze N and LeBrasseur NK and Miller JD and Jurk D and Singh RJ and Allison DB and Ejima K and Hubbard GB and Ikeno Y and Cubro H and Garovic VD and Hou X and Weroha SJ and Robbins PD and Niedernhofer LJ and Khosla S and Tchkonia T and Kirkland JL},
  year = {2018},
  journal = {Nature medicine},
  doi = {10.1038/s41591-018-0092-9},
  url = {https://doi.org/10.1038/s41591-018-0092-9}
}

RIS

TY  - JOUR
TI  - Senolytics improve physical function and increase lifespan in old age.
AU  - Xu M
AU  - Pirtskhalava T
AU  - Farr JN
AU  - Weigand BM
AU  - Palmer AK
AU  - Weivoda MM
AU  - Inman CL
AU  - Ogrodnik MB
AU  - Hachfeld CM
AU  - Fraser DG
AU  - Onken JL
AU  - Johnson KO
AU  - Verzosa GC
AU  - Langhi LGP
AU  - Weigl M
AU  - Giorgadze N
AU  - LeBrasseur NK
AU  - Miller JD
AU  - Jurk D
AU  - Singh RJ
AU  - Allison DB
AU  - Ejima K
AU  - Hubbard GB
AU  - Ikeno Y
AU  - Cubro H
AU  - Garovic VD
AU  - Hou X
AU  - Weroha SJ
AU  - Robbins PD
AU  - Niedernhofer LJ
AU  - Khosla S
AU  - Tchkonia T
AU  - Kirkland JL
PY  - 2018
JO  - Nature medicine
DO  - 10.1038/s41591-018-0092-9
UR  - https://doi.org/10.1038/s41591-018-0092-9
ER  -

APA

M, X., T, P., JN, F., BM, W., AK, P., MM, W., CL, I., MB, O., CM, H., DG, F., JL, O., KO, J., GC, V., LGP, L., M, W., N, G., NK, L., JD, M., D, J., RJ, S., DB, A., K, E., GB, H., Y, I., H, C., VD, G., X, H., SJ, W., PD, R., LJ, N., S, K., T, T., & JL, K. (2018). Senolytics improve physical function and increase lifespan in old age.. Nature medicine. https://doi.org/10.1038/s41591-018-0092-9

Source records

pubmed · retrieved 2026-09-26T06:52:28.298Z