Anticoagulation to prevent ischemic stroke and neurocognitive impairment in atrial fibrillation: the BRAIN-AF randomized clinical trial

Léna Rivard, Paul Khairy, Mario Talajic, Jean-Claude Tardif, Jeffrey S. Healey, Sandra E. Black, Jason G. Andrade, Thalia S. Field, Isabelle Nault, Louis Bherer, Fadi Massoud, Stanley Nattel, Sylvain Lanthier, Normand Racine, Jean-François Roux, Isabelle Greiss, Laurent Macle, Peter G. Guerra, Rafik Tadros, Hélène Mayrand, Gilbert Gosselin, David Conen, Christian Bocti, Céline Chayer, Yan Deschaintre, Roopinder K. Sandhu, Jaimie Manlucu, Yaariv Khaykin, Atul Verma, Blandine Mondésert, Katia Dyrda, Julia Cadrin-Tourigny, Bernard Thibault, Alexandre Raymond-Paquin, Martin Aguilar, Judith Brouillette, André Roussin, Alain Robillard, Maxime Tremblay-Gravel, Louis-Philippe David, Mariève Cossette, Ratika Parkash, Marie-Claude Guertin, Denis Roy, Unknown, A. Shekhar Pandey, Francis Pichette, Miguel Barrero, Teresa Kus, Ariane Lemieux, Valérie Gaudreault, Peiman Marzban, Jorge Wong, Peter Leong Sit, David Laflamme, Ronald Fowlis, Kenneth Quadros, Anmol Kapoor, Umjeet S. Jolly, Stephen Wilton, Fabian Alejandro Azzari, Paul Dorian, François Deslongchamps, Yves Pesant, Saul Vizel, TunZan Maung, Michael Heffernan, Pablo Nery, Greg Curnew, Stéphanie Bourgeois, Vidal Essebag, Simon Kouz, Luc Cormier, John Vyselaar, Raja Chehayeb, Clarence Khoo, Anil Gupta, Ricardo Bessoudo, Rakesh Bhargava, Franco Sandrin, Gernot Schram, François St-Maurice, Winston Tsui, William Liang

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DOI
10.1038/s41591-025-04101-y
Published
2026-01
Container
Nature Medicine
Publisher
Springer Science and Business Media LLC
Open access
unknown

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BibTeX

@article{allodium:10.1038/s41591-025-04101-y,
  title = {Anticoagulation to prevent ischemic stroke and neurocognitive impairment in atrial fibrillation: the BRAIN-AF randomized clinical trial},
  author = {Léna Rivard and Paul Khairy and Mario Talajic and Jean-Claude Tardif and Jeffrey S. Healey and Sandra E. Black and Jason G. Andrade and Thalia S. Field and Isabelle Nault and Louis Bherer and Fadi Massoud and Stanley Nattel and Sylvain Lanthier and Normand Racine and Jean-François Roux and Isabelle Greiss and Laurent Macle and Peter G. Guerra and Rafik Tadros and Hélène Mayrand and Gilbert Gosselin and David Conen and Christian Bocti and Céline Chayer and Yan Deschaintre and Roopinder K. Sandhu and Jaimie Manlucu and Yaariv Khaykin and Atul Verma and Blandine Mondésert and Katia Dyrda and Julia Cadrin-Tourigny and Bernard Thibault and Alexandre Raymond-Paquin and Martin Aguilar and Judith Brouillette and André Roussin and Alain Robillard and Maxime Tremblay-Gravel and Louis-Philippe David and Mariève Cossette and Ratika Parkash and Marie-Claude Guertin and Denis Roy and Unknown and A. Shekhar Pandey and Francis Pichette and Miguel Barrero and Teresa Kus and Ariane Lemieux and Valérie Gaudreault and Peiman Marzban and Jorge Wong and Peter Leong Sit and David Laflamme and Ronald Fowlis and Kenneth Quadros and Anmol Kapoor and Umjeet S. Jolly and Stephen Wilton and Fabian Alejandro Azzari and Paul Dorian and François Deslongchamps and Yves Pesant and Saul Vizel and TunZan Maung and Michael Heffernan and Pablo Nery and Greg Curnew and Stéphanie Bourgeois and Vidal Essebag and Simon Kouz and Luc Cormier and John Vyselaar and Raja Chehayeb and Clarence Khoo and Anil Gupta and Ricardo Bessoudo and Rakesh Bhargava and Franco Sandrin and Gernot Schram and François St-Maurice and Winston Tsui and William Liang},
  year = {2026},
  journal = {Nature Medicine},
  doi = {10.1038/s41591-025-04101-y},
  url = {https://doi.org/10.1038/s41591-025-04101-y}
}

RIS

TY  - JOUR
TI  - Anticoagulation to prevent ischemic stroke and neurocognitive impairment in atrial fibrillation: the BRAIN-AF randomized clinical trial
AU  - Léna Rivard
AU  - Paul Khairy
AU  - Mario Talajic
AU  - Jean-Claude Tardif
AU  - Jeffrey S. Healey
AU  - Sandra E. Black
AU  - Jason G. Andrade
AU  - Thalia S. Field
AU  - Isabelle Nault
AU  - Louis Bherer
AU  - Fadi Massoud
AU  - Stanley Nattel
AU  - Sylvain Lanthier
AU  - Normand Racine
AU  - Jean-François Roux
AU  - Isabelle Greiss
AU  - Laurent Macle
AU  - Peter G. Guerra
AU  - Rafik Tadros
AU  - Hélène Mayrand
AU  - Gilbert Gosselin
AU  - David Conen
AU  - Christian Bocti
AU  - Céline Chayer
AU  - Yan Deschaintre
AU  - Roopinder K. Sandhu
AU  - Jaimie Manlucu
AU  - Yaariv Khaykin
AU  - Atul Verma
AU  - Blandine Mondésert
AU  - Katia Dyrda
AU  - Julia Cadrin-Tourigny
AU  - Bernard Thibault
AU  - Alexandre Raymond-Paquin
AU  - Martin Aguilar
AU  - Judith Brouillette
AU  - André Roussin
AU  - Alain Robillard
AU  - Maxime Tremblay-Gravel
AU  - Louis-Philippe David
AU  - Mariève Cossette
AU  - Ratika Parkash
AU  - Marie-Claude Guertin
AU  - Denis Roy
AU  - Unknown
AU  - A. Shekhar Pandey
AU  - Francis Pichette
AU  - Miguel Barrero
AU  - Teresa Kus
AU  - Ariane Lemieux
AU  - Valérie Gaudreault
AU  - Peiman Marzban
AU  - Jorge Wong
AU  - Peter Leong Sit
AU  - David Laflamme
AU  - Ronald Fowlis
AU  - Kenneth Quadros
AU  - Anmol Kapoor
AU  - Umjeet S. Jolly
AU  - Stephen Wilton
AU  - Fabian Alejandro Azzari
AU  - Paul Dorian
AU  - François Deslongchamps
AU  - Yves Pesant
AU  - Saul Vizel
AU  - TunZan Maung
AU  - Michael Heffernan
AU  - Pablo Nery
AU  - Greg Curnew
AU  - Stéphanie Bourgeois
AU  - Vidal Essebag
AU  - Simon Kouz
AU  - Luc Cormier
AU  - John Vyselaar
AU  - Raja Chehayeb
AU  - Clarence Khoo
AU  - Anil Gupta
AU  - Ricardo Bessoudo
AU  - Rakesh Bhargava
AU  - Franco Sandrin
AU  - Gernot Schram
AU  - François St-Maurice
AU  - Winston Tsui
AU  - William Liang
PY  - 2026
JO  - Nature Medicine
DO  - 10.1038/s41591-025-04101-y
UR  - https://doi.org/10.1038/s41591-025-04101-y
ER  - 

APA

Rivard, L., Khairy, P., Talajic, M., Tardif, J., Healey, J. S., Black, S. E., Andrade, J. G., Field, T. S., Nault, I., Bherer, L., Massoud, F., Nattel, S., Lanthier, S., Racine, N., Roux, J., Greiss, I., Macle, L., Guerra, P. G., Tadros, R., Mayrand, H., Gosselin, G., Conen, D., Bocti, C., Chayer, C., Deschaintre, Y., Sandhu, R. K., Manlucu, J., Khaykin, Y., Verma, A., Mondésert, B., Dyrda, K., Cadrin-Tourigny, J., Thibault, B., Raymond-Paquin, A., Aguilar, M., Brouillette, J., Roussin, A., Robillard, A., Tremblay-Gravel, M., David, L., Cossette, M., Parkash, R., Guertin, M., Roy, D., Unknown, Pandey, A. S., Pichette, F., Barrero, M., Kus, T., Lemieux, A., Gaudreault, V., Marzban, P., Wong, J., Sit, P. L., Laflamme, D., Fowlis, R., Quadros, K., Kapoor, A., Jolly, U. S., Wilton, S., Azzari, F. A., Dorian, P., Deslongchamps, F., Pesant, Y., Vizel, S., Maung, T., Heffernan, M., Nery, P., Curnew, G., Bourgeois, S., Essebag, V., Kouz, S., Cormier, L., Vyselaar, J., Chehayeb, R., Khoo, C., Gupta, A., Bessoudo, R., Bhargava, R., Sandrin, F., Schram, G., St-Maurice, F., Tsui, W., & Liang, W. (2026). Anticoagulation to prevent ischemic stroke and neurocognitive impairment in atrial fibrillation: the BRAIN-AF randomized clinical trial. Nature Medicine. https://doi.org/10.1038/s41591-025-04101-y

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