CD4(+) T cells mediate CAR-T cell-associated immune-related adverse events after BCMA CAR-T cell therapy.

Ho M, Paruzzo L, Noll JH, Stella F, Devi P, Ndeupen S, Day YA, Chen GM, Cohen IJ, Ramirez-Fernandez A, Waxman A, Kapur S, Chen F, Xu R, Huff A, Jarocha D, Patel V, Bochi-Layec AC, Ramasubramanian R, Liu S, Bouvier R, de Souza VB, Patel H, Li Z, Carturan A, Michener P, Hopkins CR, Koucky O, Minehart J, Dimitri A, Nabar NR, Hasanali ZS, Ciccarelli BT, Hung P, Williams E, Bartoszek R, Lavorando M, Mohan S, Gonzalez VE, Porazzi P, Bhoj VG, Apostolidis SA, Vogl DT, Porter DL, Scholler J, Diorio C, Roche AM, Everett JK, Bushman FD, Nathanson KL, Stadtmauer EA, Susanibar-Adaniya SP, Garfall AL, Ruella M, Cohen AD, Fraietta JA

Open source

DOI
10.1038/s41591-025-04121-8
Published
2026 Feb
Container
Nature medicine
Publisher
Not recorded
Open access
yes

Credibility signals

limited evidence Score 45/100 under policy 1.0.0. This is a metadata assessment, not a judgment of the paper's conclusions.

Show all credibility signals

Cite this work

BibTeX

@article{allodium:10.1038/s41591-025-04121-8,
  title = {CD4(+) T cells mediate CAR-T cell-associated immune-related adverse events after BCMA CAR-T cell therapy.},
  author = {Ho M and Paruzzo L and Noll JH and Stella F and Devi P and Ndeupen S and Day YA and Chen GM and Cohen IJ and Ramirez-Fernandez A and Waxman A and Kapur S and Chen F and Xu R and Huff A and Jarocha D and Patel V and Bochi-Layec AC and Ramasubramanian R and Liu S and Bouvier R and de Souza VB and Patel H and Li Z and Carturan A and Michener P and Hopkins CR and Koucky O and Minehart J and Dimitri A and Nabar NR and Hasanali ZS and Ciccarelli BT and Hung P and Williams E and Bartoszek R and Lavorando M and Mohan S and Gonzalez VE and Porazzi P and Bhoj VG and Apostolidis SA and Vogl DT and Porter DL and Scholler J and Diorio C and Roche AM and Everett JK and Bushman FD and Nathanson KL and Stadtmauer EA and Susanibar-Adaniya SP and Garfall AL and Ruella M and Cohen AD and Fraietta JA},
  year = {2026},
  journal = {Nature medicine},
  doi = {10.1038/s41591-025-04121-8},
  url = {https://doi.org/10.1038/s41591-025-04121-8}
}

RIS

TY  - JOUR
TI  - CD4(+) T cells mediate CAR-T cell-associated immune-related adverse events after BCMA CAR-T cell therapy.
AU  - Ho M
AU  - Paruzzo L
AU  - Noll JH
AU  - Stella F
AU  - Devi P
AU  - Ndeupen S
AU  - Day YA
AU  - Chen GM
AU  - Cohen IJ
AU  - Ramirez-Fernandez A
AU  - Waxman A
AU  - Kapur S
AU  - Chen F
AU  - Xu R
AU  - Huff A
AU  - Jarocha D
AU  - Patel V
AU  - Bochi-Layec AC
AU  - Ramasubramanian R
AU  - Liu S
AU  - Bouvier R
AU  - de Souza VB
AU  - Patel H
AU  - Li Z
AU  - Carturan A
AU  - Michener P
AU  - Hopkins CR
AU  - Koucky O
AU  - Minehart J
AU  - Dimitri A
AU  - Nabar NR
AU  - Hasanali ZS
AU  - Ciccarelli BT
AU  - Hung P
AU  - Williams E
AU  - Bartoszek R
AU  - Lavorando M
AU  - Mohan S
AU  - Gonzalez VE
AU  - Porazzi P
AU  - Bhoj VG
AU  - Apostolidis SA
AU  - Vogl DT
AU  - Porter DL
AU  - Scholler J
AU  - Diorio C
AU  - Roche AM
AU  - Everett JK
AU  - Bushman FD
AU  - Nathanson KL
AU  - Stadtmauer EA
AU  - Susanibar-Adaniya SP
AU  - Garfall AL
AU  - Ruella M
AU  - Cohen AD
AU  - Fraietta JA
PY  - 2026
JO  - Nature medicine
DO  - 10.1038/s41591-025-04121-8
UR  - https://doi.org/10.1038/s41591-025-04121-8
ER  -

APA

M, H., L, P., JH, N., F, S., P, D., S, N., YA, D., GM, C., IJ, C., A, R., A, W., S, K., F, C., R, X., A, H., D, J., V, P., AC, B., R, R., S, L., R, B., VB, D. S., H, P., Z, L., A, C., P, M., CR, H., O, K., J, M., A, D., NR, N., ZS, H., BT, C., P, H., E, W., R, B., M, L., S, M., VE, G., P, P., VG, B., SA, A., DT, V., DL, P., J, S., C, D., AM, R., JK, E., FD, B., KL, N., EA, S., SP, S., AL, G., M, R., AD, C., & JA, F. (2026). CD4(+) T cells mediate CAR-T cell-associated immune-related adverse events after BCMA CAR-T cell therapy.. Nature medicine. https://doi.org/10.1038/s41591-025-04121-8

Source records