AI-based characterization of Alzheimer’s disease phenotypes from population-scale single-cell data

Chenfeng He, Athan Z. Li, Kalpana Hanthanan Arachchilage, Chirag Gupta, Xiang Huang, Xinyu Zhao, Carissa L. Sirois, Unknown, Aram Hong, Biao Zeng, Christian Dillard, Christian Porras, Clara Casey, Colleen A. McClung, Collin Spencer, Daifeng Wang, David A. Bennett, David Burstein, Deepika Mathur, Donghoon Lee, Fotios Tsetsos, Gabriel E. Hoffman, Gennadi Ryan, Georgios Voloudakis, Hui Yang, Jaroslav Bendl, Jennifer Monteiro Fortes, Jerome J. Choi, John F. Fullard, Kalpana Hanthanan Arachchilage, Karen Therrien, Kiran Girdhar, Lars J. Jensen, Lisa L. Barnes, Logan C. Dumitrescu, Lyra Sheu, Madeline R. Scott, Marcela Alvia, Marios Anyfantakis, Maxim Signaevsky, Mikaela Koutrouli, Milos Pjanic, Monika Ahirwar, Nicolas Y. Masse, Noah Cohen Kalafut, Panos Roussos, Pavan K. Auluck, Pavel Katsel, Pengfei Dong, Pramod B. Chandrashekar, Prashant N. M, Rachel Bercovitch, Roman Kosoy, Sanan Venkatesh, Saniya Khullar, Sarah R. Murphy, Sayali A. Alatkar, Seon Kinrot, Stathis Argyriou, Stefano Marenco, Steven Finkbeiner, Steven P. Kleopoulos, Tereza Clarence, Timothy J. Hohman, Ting Jin, Vahram Haroutunian, Vivek G. Ramaswamy, Xinyi Wang, Zhenyi Wu, Zhiping Shao, Kiran Girdhar, Georgios Voloudakis, Gabriel E. Hoffman, Jaroslav Bendl, John F. Fullard, Donghoon Lee, Panos Roussos, Daifeng Wang

Open source

DOI: 10.1038/s41591-025-04128-1
Published: 2026-09-23
Container: Nature Medicine
Publisher: Springer Science and Business Media LLC
Open access: unknown

Credibility signals

uncertain Score 64/100 under policy 1.0.0. This is a metadata assessment, not a judgment of the paper's conclusions.

Show all credibility signals

supportingDOI registered: A matching record was returned by Crossref. Source: Crossref; license: CC0 metadata
supportingDOI resolves: A matching record was returned by Crossref. Source: Crossref; license: CC0 metadata
not scoredDirectory of Open Access Journals: No matching DOAJ record was present in this response. No allow-list match; this is not evidence of low credibility. Source: DOAJ; license: CC0
not scoredMEDLINE indexed: Not checked or no result supplied; no credibility inference made. Source: No authority result supplied; license: Unknown
not scoredOpenAlex core source: Not checked or no result supplied; no credibility inference made. Source: No authority result supplied; license: Unknown
not scoredKnown publisher allow-list: Not checked or no result supplied; no credibility inference made. Source: No authority result supplied; license: Unknown
not scoredROR affiliation: Not checked or no result supplied; no credibility inference made. Source: No authority result supplied; license: Unknown
not scoredRetraction Watch retraction: No retraction notice matched this DOI in the deployed snapshot. No matching event found; coverage may be incomplete. Source: Retraction Watch; license: CC BY 4.0
not scoredRetraction Watch expression of concern: No expression of concern notice matched this DOI in the deployed snapshot. No matching event found; coverage may be incomplete. Source: Retraction Watch; license: CC BY 4.0
not scoredRetraction Watch correction: No correction notice matched this DOI in the deployed snapshot. No matching event found; coverage may be incomplete. Source: Retraction Watch; license: CC BY 4.0
not scoredRetraction Watch reinstatement: No reinstatement notice matched this DOI in the deployed snapshot. No matching event found; coverage may be incomplete. Source: Retraction Watch; license: CC BY 4.0
not scoredOpen access status: Not checked or no result supplied; no credibility inference made. Source: No authority result supplied; license: Unknown
not scoredPublication license: Not checked or no result supplied; no credibility inference made. Source: No authority result supplied; license: Unknown
not scoredPublication version: A publication version was supplied but is not scored. Source: Normalized work metadata; license: Caller-provided; provenance license not supplied to scorer
supportingMetadata completeness: All 6 scored descriptive metadata groups are present. Source: Normalized work metadata; license: Caller-provided; provenance license not supplied to scorer

Cite this work

BibTeX

@article{allodium:10.1038/s41591-025-04128-1,
title = {AI-based characterization of Alzheimer’s disease phenotypes from population-scale single-cell data},
author = {Chenfeng He and Athan Z. Li and Kalpana Hanthanan Arachchilage and Chirag Gupta and Xiang Huang and Xinyu Zhao and Carissa L. Sirois and Unknown and Aram Hong and Biao Zeng and Christian Dillard and Christian Porras and Clara Casey and Colleen A. McClung and Collin Spencer and Daifeng Wang and David A. Bennett and David Burstein and Deepika Mathur and Donghoon Lee and Fotios Tsetsos and Gabriel E. Hoffman and Gennadi Ryan and Georgios Voloudakis and Hui Yang and Jaroslav Bendl and Jennifer Monteiro Fortes and Jerome J. Choi and John F. Fullard and Kalpana Hanthanan Arachchilage and Karen Therrien and Kiran Girdhar and Lars J. Jensen and Lisa L. Barnes and Logan C. Dumitrescu and Lyra Sheu and Madeline R. Scott and Marcela Alvia and Marios Anyfantakis and Maxim Signaevsky and Mikaela Koutrouli and Milos Pjanic and Monika Ahirwar and Nicolas Y. Masse and Noah Cohen Kalafut and Panos Roussos and Pavan K. Auluck and Pavel Katsel and Pengfei Dong and Pramod B. Chandrashekar and Prashant N. M and Rachel Bercovitch and Roman Kosoy and Sanan Venkatesh and Saniya Khullar and Sarah R. Murphy and Sayali A. Alatkar and Seon Kinrot and Stathis Argyriou and Stefano Marenco and Steven Finkbeiner and Steven P. Kleopoulos and Tereza Clarence and Timothy J. Hohman and Ting Jin and Vahram Haroutunian and Vivek G. Ramaswamy and Xinyi Wang and Zhenyi Wu and Zhiping Shao and Kiran Girdhar and Georgios Voloudakis and Gabriel E. Hoffman and Jaroslav Bendl and John F. Fullard and Donghoon Lee and Panos Roussos and Daifeng Wang},
year = {2026},
journal = {Nature Medicine},
doi = {10.1038/s41591-025-04128-1},
url = {https://doi.org/10.1038/s41591-025-04128-1}
}

RIS

TY  - JOUR
TI  - AI-based characterization of Alzheimer’s disease phenotypes from population-scale single-cell data
AU  - Chenfeng He
AU  - Athan Z. Li
AU  - Kalpana Hanthanan Arachchilage
AU  - Chirag Gupta
AU  - Xiang Huang
AU  - Xinyu Zhao
AU  - Carissa L. Sirois
AU  - Unknown
AU  - Aram Hong
AU  - Biao Zeng
AU  - Christian Dillard
AU  - Christian Porras
AU  - Clara Casey
AU  - Colleen A. McClung
AU  - Collin Spencer
AU  - Daifeng Wang
AU  - David A. Bennett
AU  - David Burstein
AU  - Deepika Mathur
AU  - Donghoon Lee
AU  - Fotios Tsetsos
AU  - Gabriel E. Hoffman
AU  - Gennadi Ryan
AU  - Georgios Voloudakis
AU  - Hui Yang
AU  - Jaroslav Bendl
AU  - Jennifer Monteiro Fortes
AU  - Jerome J. Choi
AU  - John F. Fullard
AU  - Kalpana Hanthanan Arachchilage
AU  - Karen Therrien
AU  - Kiran Girdhar
AU  - Lars J. Jensen
AU  - Lisa L. Barnes
AU  - Logan C. Dumitrescu
AU  - Lyra Sheu
AU  - Madeline R. Scott
AU  - Marcela Alvia
AU  - Marios Anyfantakis
AU  - Maxim Signaevsky
AU  - Mikaela Koutrouli
AU  - Milos Pjanic
AU  - Monika Ahirwar
AU  - Nicolas Y. Masse
AU  - Noah Cohen Kalafut
AU  - Panos Roussos
AU  - Pavan K. Auluck
AU  - Pavel Katsel
AU  - Pengfei Dong
AU  - Pramod B. Chandrashekar
AU  - Prashant N. M
AU  - Rachel Bercovitch
AU  - Roman Kosoy
AU  - Sanan Venkatesh
AU  - Saniya Khullar
AU  - Sarah R. Murphy
AU  - Sayali A. Alatkar
AU  - Seon Kinrot
AU  - Stathis Argyriou
AU  - Stefano Marenco
AU  - Steven Finkbeiner
AU  - Steven P. Kleopoulos
AU  - Tereza Clarence
AU  - Timothy J. Hohman
AU  - Ting Jin
AU  - Vahram Haroutunian
AU  - Vivek G. Ramaswamy
AU  - Xinyi Wang
AU  - Zhenyi Wu
AU  - Zhiping Shao
AU  - Kiran Girdhar
AU  - Georgios Voloudakis
AU  - Gabriel E. Hoffman
AU  - Jaroslav Bendl
AU  - John F. Fullard
AU  - Donghoon Lee
AU  - Panos Roussos
AU  - Daifeng Wang
PY  - 2026
JO  - Nature Medicine
DO  - 10.1038/s41591-025-04128-1
UR  - https://doi.org/10.1038/s41591-025-04128-1
ER  -

APA

He, C., Li, A. Z., Arachchilage, K. H., Gupta, C., Huang, X., Zhao, X., Sirois, C. L., Unknown, Hong, A., Zeng, B., Dillard, C., Porras, C., Casey, C., McClung, C. A., Spencer, C., Wang, D., Bennett, D. A., Burstein, D., Mathur, D., Lee, D., Tsetsos, F., Hoffman, G. E., Ryan, G., Voloudakis, G., Yang, H., Bendl, J., Fortes, J. M., Choi, J. J., Fullard, J. F., Arachchilage, K. H., Therrien, K., Girdhar, K., Jensen, L. J., Barnes, L. L., Dumitrescu, L. C., Sheu, L., Scott, M. R., Alvia, M., Anyfantakis, M., Signaevsky, M., Koutrouli, M., Pjanic, M., Ahirwar, M., Masse, N. Y., Kalafut, N. C., Roussos, P., Auluck, P. K., Katsel, P., Dong, P., Chandrashekar, P. B., M, P. N., Bercovitch, R., Kosoy, R., Venkatesh, S., Khullar, S., Murphy, S. R., Alatkar, S. A., Kinrot, S., Argyriou, S., Marenco, S., Finkbeiner, S., Kleopoulos, S. P., Clarence, T., Hohman, T. J., Jin, T., Haroutunian, V., Ramaswamy, V. G., Wang, X., Wu, Z., Shao, Z., Girdhar, K., Voloudakis, G., Hoffman, G. E., Bendl, J., Fullard, J. F., Lee, D., Roussos, P., & Wang, D. (2026). AI-based characterization of Alzheimer’s disease phenotypes from population-scale single-cell data. Nature Medicine. https://doi.org/10.1038/s41591-025-04128-1

Source records

crossref · retrieved 2026-09-25T14:46:47.324Z