BCMA-directed mRNA CAR-T cell therapy for myasthenia gravis: exploratory biomarker analysis of a placebo-controlled phase 2b trial

Renee R. Fedak, Rachel N. Ruggerie, Yufei Shan, Elizabeth J. Curvino, Juliana F. de Sousa, Shaji Daniel, Minhtran Ngo-Casi, Hafsa Kamboh, Tuan Vu, Hacer Durmuş, Tahseen Mozaffar, James F. Howard, Emily P. English, Albina Benson, Matthew T. Duvernay, Michael S. Singer, Murat V. Kalayoglu, Carsten Brunn, Aaron Bodansky, Mark S. Anderson, Joseph L. DeRisi, Samantha T. Garcia, David J. L. Yu, Kelsey C. Zorn, Metin Kurtoglu, Miloš D. Miljković, C. Andrew Stewart, Christopher M. Jewell, Unknown, Juliana F. de Sousa, Charito Buensuceso, Lisa H. Tostanoski, Yi Zhang, Heng Xu, Chad A. Pope, Dina Schneider, Adam English, Atanas Filev, Jennifer Biaksangi, George Small, Michael Rivner, Michael A. Badruddoja, Bennett Myers, Sheetal Shroff, Adam Slanksy, Kelly Holley, Gregory Sahagian, Tara Quesnell, Marc H. Feinberg, Gabrielle DeMaria, Mithila Vullaganti, Carolina Barnett-Tapia, Meg Mendoza, Mona Irannejad, Zaeem Siddiqi, Ali A. Habib, Thomas Ragole, Mamatha Pasnoor, Rebecca E. Traub, Manisha Chopra, Natalie S. Grover, Yara A. Park, Matthew Karafin, Amy Trunnell, Catherine Cheng, Chafic Karam, Darnell Davis, Jessica Shaw, Naraly Requena, Amanda Peltier, Kelly Gwathmey

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DOI: 10.1038/s41591-025-04170-z
Published: 2026-01-09
Container: Nature Medicine
Publisher: Springer Science and Business Media LLC
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Cite this work

BibTeX

@article{allodium:10.1038/s41591-025-04170-z,
title = {BCMA-directed mRNA CAR-T cell therapy for myasthenia gravis: exploratory biomarker analysis of a placebo-controlled phase 2b trial},
author = {Renee R. Fedak and Rachel N. Ruggerie and Yufei Shan and Elizabeth J. Curvino and Juliana F. de Sousa and Shaji Daniel and Minhtran Ngo-Casi and Hafsa Kamboh and Tuan Vu and Hacer Durmuş and Tahseen Mozaffar and James F. Howard and Emily P. English and Albina Benson and Matthew T. Duvernay and Michael S. Singer and Murat V. Kalayoglu and Carsten Brunn and Aaron Bodansky and Mark S. Anderson and Joseph L. DeRisi and Samantha T. Garcia and David J. L. Yu and Kelsey C. Zorn and Metin Kurtoglu and Miloš D. Miljković and C. Andrew Stewart and Christopher M. Jewell and Unknown and Juliana F. de Sousa and Charito Buensuceso and Lisa H. Tostanoski and Yi Zhang and Heng Xu and Chad A. Pope and Dina Schneider and Adam English and Atanas Filev and Jennifer Biaksangi and George Small and Michael Rivner and Michael A. Badruddoja and Bennett Myers and Sheetal Shroff and Adam Slanksy and Kelly Holley and Gregory Sahagian and Tara Quesnell and Marc H. Feinberg and Gabrielle DeMaria and Mithila Vullaganti and Carolina Barnett-Tapia and Meg Mendoza and Mona Irannejad and Zaeem Siddiqi and Ali A. Habib and Thomas Ragole and Mamatha Pasnoor and Rebecca E. Traub and Manisha Chopra and Natalie S. Grover and Yara A. Park and Matthew Karafin and Amy Trunnell and Catherine Cheng and Chafic Karam and Darnell Davis and Jessica Shaw and Naraly Requena and Amanda Peltier and Kelly Gwathmey},
year = {2026},
journal = {Nature Medicine},
doi = {10.1038/s41591-025-04170-z},
url = {https://doi.org/10.1038/s41591-025-04170-z}
}

RIS

TY  - JOUR
TI  - BCMA-directed mRNA CAR-T cell therapy for myasthenia gravis: exploratory biomarker analysis of a placebo-controlled phase 2b trial
AU  - Renee R. Fedak
AU  - Rachel N. Ruggerie
AU  - Yufei Shan
AU  - Elizabeth J. Curvino
AU  - Juliana F. de Sousa
AU  - Shaji Daniel
AU  - Minhtran Ngo-Casi
AU  - Hafsa Kamboh
AU  - Tuan Vu
AU  - Hacer Durmuş
AU  - Tahseen Mozaffar
AU  - James F. Howard
AU  - Emily P. English
AU  - Albina Benson
AU  - Matthew T. Duvernay
AU  - Michael S. Singer
AU  - Murat V. Kalayoglu
AU  - Carsten Brunn
AU  - Aaron Bodansky
AU  - Mark S. Anderson
AU  - Joseph L. DeRisi
AU  - Samantha T. Garcia
AU  - David J. L. Yu
AU  - Kelsey C. Zorn
AU  - Metin Kurtoglu
AU  - Miloš D. Miljković
AU  - C. Andrew Stewart
AU  - Christopher M. Jewell
AU  - Unknown
AU  - Juliana F. de Sousa
AU  - Charito Buensuceso
AU  - Lisa H. Tostanoski
AU  - Yi Zhang
AU  - Heng Xu
AU  - Chad A. Pope
AU  - Dina Schneider
AU  - Adam English
AU  - Atanas Filev
AU  - Jennifer Biaksangi
AU  - George Small
AU  - Michael Rivner
AU  - Michael A. Badruddoja
AU  - Bennett Myers
AU  - Sheetal Shroff
AU  - Adam Slanksy
AU  - Kelly Holley
AU  - Gregory Sahagian
AU  - Tara Quesnell
AU  - Marc H. Feinberg
AU  - Gabrielle DeMaria
AU  - Mithila Vullaganti
AU  - Carolina Barnett-Tapia
AU  - Meg Mendoza
AU  - Mona Irannejad
AU  - Zaeem Siddiqi
AU  - Ali A. Habib
AU  - Thomas Ragole
AU  - Mamatha Pasnoor
AU  - Rebecca E. Traub
AU  - Manisha Chopra
AU  - Natalie S. Grover
AU  - Yara A. Park
AU  - Matthew Karafin
AU  - Amy Trunnell
AU  - Catherine Cheng
AU  - Chafic Karam
AU  - Darnell Davis
AU  - Jessica Shaw
AU  - Naraly Requena
AU  - Amanda Peltier
AU  - Kelly Gwathmey
PY  - 2026
JO  - Nature Medicine
DO  - 10.1038/s41591-025-04170-z
UR  - https://doi.org/10.1038/s41591-025-04170-z
ER  -

APA

Fedak, R. R., Ruggerie, R. N., Shan, Y., Curvino, E. J., Sousa, J. F. D., Daniel, S., Ngo-Casi, M., Kamboh, H., Vu, T., Durmuş, H., Mozaffar, T., Howard, J. F., English, E. P., Benson, A., Duvernay, M. T., Singer, M. S., Kalayoglu, M. V., Brunn, C., Bodansky, A., Anderson, M. S., DeRisi, J. L., Garcia, S. T., Yu, D. J. L., Zorn, K. C., Kurtoglu, M., Miljković, M. D., Stewart, C. A., Jewell, C. M., Unknown, Sousa, J. F. D., Buensuceso, C., Tostanoski, L. H., Zhang, Y., Xu, H., Pope, C. A., Schneider, D., English, A., Filev, A., Biaksangi, J., Small, G., Rivner, M., Badruddoja, M. A., Myers, B., Shroff, S., Slanksy, A., Holley, K., Sahagian, G., Quesnell, T., Feinberg, M. H., DeMaria, G., Vullaganti, M., Barnett-Tapia, C., Mendoza, M., Irannejad, M., Siddiqi, Z., Habib, A. A., Ragole, T., Pasnoor, M., Traub, R. E., Chopra, M., Grover, N. S., Park, Y. A., Karafin, M., Trunnell, A., Cheng, C., Karam, C., Davis, D., Shaw, J., Requena, N., Peltier, A., & Gwathmey, K. (2026). BCMA-directed mRNA CAR-T cell therapy for myasthenia gravis: exploratory biomarker analysis of a placebo-controlled phase 2b trial. Nature Medicine. https://doi.org/10.1038/s41591-025-04170-z

Source records

crossref · retrieved 2026-09-26T23:08:56.637Z