Pembrolizumab and olaparib in homologous-recombination-deficient metastatic pancreatic cancer: the phase 2 POLAR trial

Wungki Park, Catherine A. O’Connor, Joanne F. Chou, Marc Hilmi, Zeynep Tarcan, Carly Schwartz, Mary Larsen, Ramzi Homsi, Karthigayini Sivaprakasam, Shigeaki Umeda, Maria A. Perry, Anna M. Varghese, Kenneth H. Yu, Fiyinfolu Balogun, Alice Zervoudakis, Seth S. Katz, Tae-Hyung Kim, Ken Zhao, Allison L. Richards, Nicolas Lecomte, Daniel Martin Muldoon, Elias Karnoub, Walid Chatila, Jessica Yang, Imane El-Dika, Devika Rao, Smita Joshi, Michael B. Foote, Ryan Sugarman, James J. Harding, Andrew S. Epstein, David Kelsen, Sree Chalassani, Fergus Keane, Joshua D. Schoenfeld, Anupriya Singhal, Erin Diguglielmo, Chaitanya Bandlamudi, Junmin Song, Hulya Sahin Ozkan, Junguei Hong, Haochen Zhang, Agustin III Cardenas, Maria Lao, Jerry Melchor, Ronak Shah, Wenfei Kang, Francesca Mazzoni, Kevin Soares, Mark TA Donoghue, Ernesto Santos, Vineet Rolston, Marsha Reyngold, Alice Chia-chi Wei, Murray Tipping, Olca Basturk, Michael Berger, Richard Kihn Do, Mark Schattner, William R. Jarnagin, Nadeem Riaz, Vinod Balachandran, Dana Pe’er, Marinela Capanu, Christine Iacobuzio-Donahue, Eileen M. O’Reilly

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DOI: 10.1038/s41591-026-04299-5
Published: 2026-03-25
Container: Nature Medicine
Publisher: Springer Science and Business Media LLC
Open access: unknown

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Cite this work

BibTeX

@article{allodium:10.1038/s41591-026-04299-5,
title = {Pembrolizumab and olaparib in homologous-recombination-deficient metastatic pancreatic cancer: the phase 2 POLAR trial},
author = {Wungki Park and Catherine A. O’Connor and Joanne F. Chou and Marc Hilmi and Zeynep Tarcan and Carly Schwartz and Mary Larsen and Ramzi Homsi and Karthigayini Sivaprakasam and Shigeaki Umeda and Maria A. Perry and Anna M. Varghese and Kenneth H. Yu and Fiyinfolu Balogun and Alice Zervoudakis and Seth S. Katz and Tae-Hyung Kim and Ken Zhao and Allison L. Richards and Nicolas Lecomte and Daniel Martin Muldoon and Elias Karnoub and Walid Chatila and Jessica Yang and Imane El-Dika and Devika Rao and Smita Joshi and Michael B. Foote and Ryan Sugarman and James J. Harding and Andrew S. Epstein and David Kelsen and Sree Chalassani and Fergus Keane and Joshua D. Schoenfeld and Anupriya Singhal and Erin Diguglielmo and Chaitanya Bandlamudi and Junmin Song and Hulya Sahin Ozkan and Junguei Hong and Haochen Zhang and Agustin III Cardenas and Maria Lao and Jerry Melchor and Ronak Shah and Wenfei Kang and Francesca Mazzoni and Kevin Soares and Mark TA Donoghue and Ernesto Santos and Vineet Rolston and Marsha Reyngold and Alice Chia-chi Wei and Murray Tipping and Olca Basturk and Michael Berger and Richard Kihn Do and Mark Schattner and William R. Jarnagin and Nadeem Riaz and Vinod Balachandran and Dana Pe’er and Marinela Capanu and Christine Iacobuzio-Donahue and Eileen M. O’Reilly},
year = {2026},
journal = {Nature Medicine},
doi = {10.1038/s41591-026-04299-5},
url = {https://doi.org/10.1038/s41591-026-04299-5}
}

RIS

TY  - JOUR
TI  - Pembrolizumab and olaparib in homologous-recombination-deficient metastatic pancreatic cancer: the phase 2 POLAR trial
AU  - Wungki Park
AU  - Catherine A. O’Connor
AU  - Joanne F. Chou
AU  - Marc Hilmi
AU  - Zeynep Tarcan
AU  - Carly Schwartz
AU  - Mary Larsen
AU  - Ramzi Homsi
AU  - Karthigayini Sivaprakasam
AU  - Shigeaki Umeda
AU  - Maria A. Perry
AU  - Anna M. Varghese
AU  - Kenneth H. Yu
AU  - Fiyinfolu Balogun
AU  - Alice Zervoudakis
AU  - Seth S. Katz
AU  - Tae-Hyung Kim
AU  - Ken Zhao
AU  - Allison L. Richards
AU  - Nicolas Lecomte
AU  - Daniel Martin Muldoon
AU  - Elias Karnoub
AU  - Walid Chatila
AU  - Jessica Yang
AU  - Imane El-Dika
AU  - Devika Rao
AU  - Smita Joshi
AU  - Michael B. Foote
AU  - Ryan Sugarman
AU  - James J. Harding
AU  - Andrew S. Epstein
AU  - David Kelsen
AU  - Sree Chalassani
AU  - Fergus Keane
AU  - Joshua D. Schoenfeld
AU  - Anupriya Singhal
AU  - Erin Diguglielmo
AU  - Chaitanya Bandlamudi
AU  - Junmin Song
AU  - Hulya Sahin Ozkan
AU  - Junguei Hong
AU  - Haochen Zhang
AU  - Agustin III Cardenas
AU  - Maria Lao
AU  - Jerry Melchor
AU  - Ronak Shah
AU  - Wenfei Kang
AU  - Francesca Mazzoni
AU  - Kevin Soares
AU  - Mark TA Donoghue
AU  - Ernesto Santos
AU  - Vineet Rolston
AU  - Marsha Reyngold
AU  - Alice Chia-chi Wei
AU  - Murray Tipping
AU  - Olca Basturk
AU  - Michael Berger
AU  - Richard Kihn Do
AU  - Mark Schattner
AU  - William R. Jarnagin
AU  - Nadeem Riaz
AU  - Vinod Balachandran
AU  - Dana Pe’er
AU  - Marinela Capanu
AU  - Christine Iacobuzio-Donahue
AU  - Eileen M. O’Reilly
PY  - 2026
JO  - Nature Medicine
DO  - 10.1038/s41591-026-04299-5
UR  - https://doi.org/10.1038/s41591-026-04299-5
ER  -

APA

Park, W., O’Connor, C. A., Chou, J. F., Hilmi, M., Tarcan, Z., Schwartz, C., Larsen, M., Homsi, R., Sivaprakasam, K., Umeda, S., Perry, M. A., Varghese, A. M., Yu, K. H., Balogun, F., Zervoudakis, A., Katz, S. S., Kim, T., Zhao, K., Richards, A. L., Lecomte, N., Muldoon, D. M., Karnoub, E., Chatila, W., Yang, J., El-Dika, I., Rao, D., Joshi, S., Foote, M. B., Sugarman, R., Harding, J. J., Epstein, A. S., Kelsen, D., Chalassani, S., Keane, F., Schoenfeld, J. D., Singhal, A., Diguglielmo, E., Bandlamudi, C., Song, J., Ozkan, H. S., Hong, J., Zhang, H., Cardenas, A. I., Lao, M., Melchor, J., Shah, R., Kang, W., Mazzoni, F., Soares, K., Donoghue, M. T., Santos, E., Rolston, V., Reyngold, M., Wei, A. C., Tipping, M., Basturk, O., Berger, M., Do, R. K., Schattner, M., Jarnagin, W. R., Riaz, N., Balachandran, V., Pe’er, D., Capanu, M., Iacobuzio-Donahue, C., & O’Reilly, E. M. (2026). Pembrolizumab and olaparib in homologous-recombination-deficient metastatic pancreatic cancer: the phase 2 POLAR trial. Nature Medicine. https://doi.org/10.1038/s41591-026-04299-5

Source records

crossref · retrieved 2026-09-25T23:48:50.491Z