The exposome of brain aging across 34 countries

Agustina Legaz, Sebastian Moguilner, Pablo Barttfeld, Jhosmary Cuadros Castro, Dante Sebastián Galván Rial, Joaquin Migeot, Francesca R. Farina, Raul Gonzalez-Gomez, Salomón Salazar-Londoño, Tiago de Souza Azzi, Sarael Alcauter, Lucia Amoruso, Renato Anghinah, May Bakr, María Isabel Behrens, Martin A. Bruno, Juan Felipe Cardona, Christopher Chen, Olivier Colliot, Nilton Custodio, Quentin d’Acremont, Stéphanie Debette, Patrycja Dzianok, Bahar Güntekin, Jordi Huguet, Cecilia Jarne, Marc Joliot, Elissaios Karageorgiou, Eman M. Khedr, Sheri-Michelle Koopowitz, Ewa Kublik, Jinkook Lee, Leon Aksman, Susanna Lopez, Paula Margaretic, Diana Matallana, Sophie Matis, Andreas Miltiadous, Gabriela Novotni, Patricio Orio, Mario A. Parra, Simone Reppermund, Elisa de Paula França Resende, Giovanni Abrahão Salum, Andrea Slachevsky, Ana Luisa Sosa Ortiz, Leonel Tadao Takada, An Qi Toh, Alexandros Tzallas, Wei Wen, Robert Whelan, Görsev Yener, Jonathan Adrián Zegarra Valdivia, Athanasia Alexoudi, Faheem Arshad, Haisam Atta, Jose Alberto Avila-Funes, Jasmin Bonilla Santos, Ricardo Bruña, Sandra Milena Castelblanco-Toro, Brenda Nadia Chino Vilca, Carlos Coronel-Oliveros, Fabrice Crivello, Josephine Cruzat, Damián Dellavale, Catherina Dhooge, Gaetano Di Caterina, Javier Escudero, Juan Manuel Esquivias Farias, Laz Ude Eze, Tavia E. Evans, Temitope Farombi, Alberto Fernández, Sol Fittipaldi, Florencia Portillo, Gonzalo Forno Martinic, Adolfo M. García, Indira Garcia-Cordero, Rahul Gaurav, Maria Eugenia Godoy, Cecilia Gonzalez Campo, Alfredis González Hernández, Lütfü Hanoğlu, Jessica L. Hazelton, Rubén Herzog, Burcin Ikiz, Alfred Kongnyu Njamnshi, Ramon Landin-Romero, María Eugenia López, Marcelo Adrián Maito, Vicente Medel, Juan Pablo Morales Sepúlveda, John Fredy Ochoa Gómez, Chukwuanugo Ogbuagu, Maira Okada de Oliveira, Mehmet Ozansoy, Javier Palma-Espinosa, Saima Hilal, Juan Helen Zhou, Stefanie Danielle Piña Escudero, Julie Kay Pitman, Pavel Prado, Diego Ramírez González, Pablo Reyes, Hernando Santamaría García, Johannes Schröder, Jacobo Diego Sitt, Radwa Kamel Soliman, Marcio Soto-Añari, Nithin Thanissery, Lucas Toshio Ito, Ami Tsuchida, Christophe Tzourio, Harun Yırıkoğulları, Jennifer S. Yokoyama, David Aguillon, Bruce Miller, Suvarna Alladi, Yang Jiang, Arcadi Navarro, Claudio Babiloni, David Huepe Artigas, Olivier Piguet, Pedro Antonio Valdes Sosa, Cyprian M. Mostert, Masoud Tahmasian, Peng Li, Kun Hu, Sarah Genon, Dan J. Stein, Fernando Maestú, Michela Pievani, Mohamed Salama, Henry Brodaty, Perminder S. Sachdev, Brian Lawlor, Harris A. Eyre, J. Jaime Miranda, Sandra Baez, Enzo Tagliazucchi, Claudia Duran-Aniotz, Hernan Hernandez, Agustin Ibanez

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DOI
10.1038/s41591-026-04302-z
Published
2026-04-03
Container
Nature Medicine
Publisher
Springer Science and Business Media LLC
Open access
unknown

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BibTeX

@article{allodium:10.1038/s41591-026-04302-z,
  title = {The exposome of brain aging across 34 countries},
  author = {Agustina Legaz and Sebastian Moguilner and Pablo Barttfeld and Jhosmary Cuadros Castro and Dante Sebastián Galván Rial and Joaquin Migeot and Francesca R. Farina and Raul Gonzalez-Gomez and Salomón Salazar-Londoño and Tiago de Souza Azzi and Sarael Alcauter and Lucia Amoruso and Renato Anghinah and May Bakr and María Isabel Behrens and Martin A. Bruno and Juan Felipe Cardona and Christopher Chen and Olivier Colliot and Nilton Custodio and Quentin d’Acremont and Stéphanie Debette and Patrycja Dzianok and Bahar Güntekin and Jordi Huguet and Cecilia Jarne and Marc Joliot and Elissaios Karageorgiou and Eman M. Khedr and Sheri-Michelle Koopowitz and Ewa Kublik and Jinkook Lee and Leon Aksman and Susanna Lopez and Paula Margaretic and Diana Matallana and Sophie Matis and Andreas Miltiadous and Gabriela Novotni and Patricio Orio and Mario A. Parra and Simone Reppermund and Elisa de Paula França Resende and Giovanni Abrahão Salum and Andrea Slachevsky and Ana Luisa Sosa Ortiz and Leonel Tadao Takada and An Qi Toh and Alexandros Tzallas and Wei Wen and Robert Whelan and Görsev Yener and Jonathan Adrián Zegarra Valdivia and Athanasia Alexoudi and Faheem Arshad and Haisam Atta and Jose Alberto Avila-Funes and Jasmin Bonilla Santos and Ricardo Bruña and Sandra Milena Castelblanco-Toro and Brenda Nadia Chino Vilca and Carlos Coronel-Oliveros and Fabrice Crivello and Josephine Cruzat and Damián Dellavale and Catherina Dhooge and Gaetano Di Caterina and Javier Escudero and Juan Manuel Esquivias Farias and Laz Ude Eze and Tavia E. Evans and Temitope Farombi and Alberto Fernández and Sol Fittipaldi and Florencia Portillo and Gonzalo Forno Martinic and Adolfo M. García and Indira Garcia-Cordero and Rahul Gaurav and Maria Eugenia Godoy and Cecilia Gonzalez Campo and Alfredis González Hernández and Lütfü Hanoğlu and Jessica L. Hazelton and Rubén Herzog and Burcin Ikiz and Alfred Kongnyu Njamnshi and Ramon Landin-Romero and María Eugenia López and Marcelo Adrián Maito and Vicente Medel and Juan Pablo Morales Sepúlveda and John Fredy Ochoa Gómez and Chukwuanugo Ogbuagu and Maira Okada de Oliveira and Mehmet Ozansoy and Javier Palma-Espinosa and Saima Hilal and Juan Helen Zhou and Stefanie Danielle Piña Escudero and Julie Kay Pitman and Pavel Prado and Diego Ramírez González and Pablo Reyes and Hernando Santamaría García and Johannes Schröder and Jacobo Diego Sitt and Radwa Kamel Soliman and Marcio Soto-Añari and Nithin Thanissery and Lucas Toshio Ito and Ami Tsuchida and Christophe Tzourio and Harun Yırıkoğulları and Jennifer S. Yokoyama and David Aguillon and Bruce Miller and Suvarna Alladi and Yang Jiang and Arcadi Navarro and Claudio Babiloni and David Huepe Artigas and Olivier Piguet and Pedro Antonio Valdes Sosa and Cyprian M. Mostert and Masoud Tahmasian and Peng Li and Kun Hu and Sarah Genon and Dan J. Stein and Fernando Maestú and Michela Pievani and Mohamed Salama and Henry Brodaty and Perminder S. Sachdev and Brian Lawlor and Harris A. Eyre and J. Jaime Miranda and Sandra Baez and Enzo Tagliazucchi and Claudia Duran-Aniotz and Hernan Hernandez and Agustin Ibanez},
  year = {2026},
  journal = {Nature Medicine},
  doi = {10.1038/s41591-026-04302-z},
  url = {https://doi.org/10.1038/s41591-026-04302-z}
}

RIS

TY  - JOUR
TI  - The exposome of brain aging across 34 countries
AU  - Agustina Legaz
AU  - Sebastian Moguilner
AU  - Pablo Barttfeld
AU  - Jhosmary Cuadros Castro
AU  - Dante Sebastián Galván Rial
AU  - Joaquin Migeot
AU  - Francesca R. Farina
AU  - Raul Gonzalez-Gomez
AU  - Salomón Salazar-Londoño
AU  - Tiago de Souza Azzi
AU  - Sarael Alcauter
AU  - Lucia Amoruso
AU  - Renato Anghinah
AU  - May Bakr
AU  - María Isabel Behrens
AU  - Martin A. Bruno
AU  - Juan Felipe Cardona
AU  - Christopher Chen
AU  - Olivier Colliot
AU  - Nilton Custodio
AU  - Quentin d’Acremont
AU  - Stéphanie Debette
AU  - Patrycja Dzianok
AU  - Bahar Güntekin
AU  - Jordi Huguet
AU  - Cecilia Jarne
AU  - Marc Joliot
AU  - Elissaios Karageorgiou
AU  - Eman M. Khedr
AU  - Sheri-Michelle Koopowitz
AU  - Ewa Kublik
AU  - Jinkook Lee
AU  - Leon Aksman
AU  - Susanna Lopez
AU  - Paula Margaretic
AU  - Diana Matallana
AU  - Sophie Matis
AU  - Andreas Miltiadous
AU  - Gabriela Novotni
AU  - Patricio Orio
AU  - Mario A. Parra
AU  - Simone Reppermund
AU  - Elisa de Paula França Resende
AU  - Giovanni Abrahão Salum
AU  - Andrea Slachevsky
AU  - Ana Luisa Sosa Ortiz
AU  - Leonel Tadao Takada
AU  - An Qi Toh
AU  - Alexandros Tzallas
AU  - Wei Wen
AU  - Robert Whelan
AU  - Görsev Yener
AU  - Jonathan Adrián Zegarra Valdivia
AU  - Athanasia Alexoudi
AU  - Faheem Arshad
AU  - Haisam Atta
AU  - Jose Alberto Avila-Funes
AU  - Jasmin Bonilla Santos
AU  - Ricardo Bruña
AU  - Sandra Milena Castelblanco-Toro
AU  - Brenda Nadia Chino Vilca
AU  - Carlos Coronel-Oliveros
AU  - Fabrice Crivello
AU  - Josephine Cruzat
AU  - Damián Dellavale
AU  - Catherina Dhooge
AU  - Gaetano Di Caterina
AU  - Javier Escudero
AU  - Juan Manuel Esquivias Farias
AU  - Laz Ude Eze
AU  - Tavia E. Evans
AU  - Temitope Farombi
AU  - Alberto Fernández
AU  - Sol Fittipaldi
AU  - Florencia Portillo
AU  - Gonzalo Forno Martinic
AU  - Adolfo M. García
AU  - Indira Garcia-Cordero
AU  - Rahul Gaurav
AU  - Maria Eugenia Godoy
AU  - Cecilia Gonzalez Campo
AU  - Alfredis González Hernández
AU  - Lütfü Hanoğlu
AU  - Jessica L. Hazelton
AU  - Rubén Herzog
AU  - Burcin Ikiz
AU  - Alfred Kongnyu Njamnshi
AU  - Ramon Landin-Romero
AU  - María Eugenia López
AU  - Marcelo Adrián Maito
AU  - Vicente Medel
AU  - Juan Pablo Morales Sepúlveda
AU  - John Fredy Ochoa Gómez
AU  - Chukwuanugo Ogbuagu
AU  - Maira Okada de Oliveira
AU  - Mehmet Ozansoy
AU  - Javier Palma-Espinosa
AU  - Saima Hilal
AU  - Juan Helen Zhou
AU  - Stefanie Danielle Piña Escudero
AU  - Julie Kay Pitman
AU  - Pavel Prado
AU  - Diego Ramírez González
AU  - Pablo Reyes
AU  - Hernando Santamaría García
AU  - Johannes Schröder
AU  - Jacobo Diego Sitt
AU  - Radwa Kamel Soliman
AU  - Marcio Soto-Añari
AU  - Nithin Thanissery
AU  - Lucas Toshio Ito
AU  - Ami Tsuchida
AU  - Christophe Tzourio
AU  - Harun Yırıkoğulları
AU  - Jennifer S. Yokoyama
AU  - David Aguillon
AU  - Bruce Miller
AU  - Suvarna Alladi
AU  - Yang Jiang
AU  - Arcadi Navarro
AU  - Claudio Babiloni
AU  - David Huepe Artigas
AU  - Olivier Piguet
AU  - Pedro Antonio Valdes Sosa
AU  - Cyprian M. Mostert
AU  - Masoud Tahmasian
AU  - Peng Li
AU  - Kun Hu
AU  - Sarah Genon
AU  - Dan J. Stein
AU  - Fernando Maestú
AU  - Michela Pievani
AU  - Mohamed Salama
AU  - Henry Brodaty
AU  - Perminder S. Sachdev
AU  - Brian Lawlor
AU  - Harris A. Eyre
AU  - J. Jaime Miranda
AU  - Sandra Baez
AU  - Enzo Tagliazucchi
AU  - Claudia Duran-Aniotz
AU  - Hernan Hernandez
AU  - Agustin Ibanez
PY  - 2026
JO  - Nature Medicine
DO  - 10.1038/s41591-026-04302-z
UR  - https://doi.org/10.1038/s41591-026-04302-z
ER  -

APA

Legaz, A., Moguilner, S., Barttfeld, P., Castro, J. C., Rial, D. S. G., Migeot, J., Farina, F. R., Gonzalez-Gomez, R., Salazar-Londoño, S., Azzi, T. D. S., Alcauter, S., Amoruso, L., Anghinah, R., Bakr, M., Behrens, M. I., Bruno, M. A., Cardona, J. F., Chen, C., Colliot, O., Custodio, N., d’Acremont, Q., Debette, S., Dzianok, P., Güntekin, B., Huguet, J., Jarne, C., Joliot, M., Karageorgiou, E., Khedr, E. M., Koopowitz, S., Kublik, E., Lee, J., Aksman, L., Lopez, S., Margaretic, P., Matallana, D., Matis, S., Miltiadous, A., Novotni, G., Orio, P., Parra, M. A., Reppermund, S., Resende, E. D. P. F., Salum, G. A., Slachevsky, A., Ortiz, A. L. S., Takada, L. T., Toh, A. Q., Tzallas, A., Wen, W., Whelan, R., Yener, G., Valdivia, J. A. Z., Alexoudi, A., Arshad, F., Atta, H., Avila-Funes, J. A., Santos, J. B., Bruña, R., Castelblanco-Toro, S. M., Vilca, B. N. C., Coronel-Oliveros, C., Crivello, F., Cruzat, J., Dellavale, D., Dhooge, C., Caterina, G. D., Escudero, J., Farias, J. M. E., Eze, L. U., Evans, T. E., Farombi, T., Fernández, A., Fittipaldi, S., Portillo, F., Martinic, G. F., García, A. M., Garcia-Cordero, I., Gaurav, R., Godoy, M. E., Campo, C. G., Hernández, A. G., Hanoğlu, L., Hazelton, J. L., Herzog, R., Ikiz, B., Njamnshi, A. K., Landin-Romero, R., López, M. E., Maito, M. A., Medel, V., Sepúlveda, J. P. M., Gómez, J. F. O., Ogbuagu, C., Oliveira, M. O. D., Ozansoy, M., Palma-Espinosa, J., Hilal, S., Zhou, J. H., Escudero, S. D. P., Pitman, J. K., Prado, P., González, D. R., Reyes, P., García, H. S., Schröder, J., Sitt, J. D., Soliman, R. K., Soto-Añari, M., Thanissery, N., Ito, L. T., Tsuchida, A., Tzourio, C., Yırıkoğulları, H., Yokoyama, J. S., Aguillon, D., Miller, B., Alladi, S., Jiang, Y., Navarro, A., Babiloni, C., Artigas, D. H., Piguet, O., Sosa, P. A. V., Mostert, C. M., Tahmasian, M., Li, P., Hu, K., Genon, S., Stein, D. J., Maestú, F., Pievani, M., Salama, M., Brodaty, H., Sachdev, P. S., Lawlor, B., Eyre, H. A., Miranda, J. J., Baez, S., Tagliazucchi, E., Duran-Aniotz, C., Hernandez, H., & Ibanez, A. (2026). The exposome of brain aging across 34 countries. Nature Medicine. https://doi.org/10.1038/s41591-026-04302-z

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