Multinational validation of the PREVENT and SCORE2 cardiovascular risk equations across 6.4 million individuals

Brendon L. Neuen, Rupert W. Major, Morgan E. Grams, Yingying Sang, Josef Coresh, Shoshana H. Ballew, Aditya Surapaneni, Natalia Alencar de Pinho, Johan Ärnlöv, Clare Arnott, Samira Bell, Jarett Berry, Hermann Brenner, Elizabeth Ciemins, Alexander R. Chang, Mary Cushman, James A. de Lemos, Juan Miguel Diaz-Tocados, Alfredo E. Farjat, Robert A. Fletcher, Ron T. Gansevoort, Hiddo J. L. Heerspink, William G. Herrington, Chuan Hong, Edward J. Horwitz, Shih-Jen Hwang, Simerjot K. Jassal, Philip A. Kalra, Ronit Katz, Sadiya S. Khan, Csaba P. Kovesdy, Florian Kronenberg, Jennifer S. Lees, Donald M. Lloyd-Jones, Jose Geraldo Mill, David M. J. Naimark, Chiadi Ndumele, Kevan R. Polkinghorne, Bruce M. Psaty, Patrick Schloemer, Michael G. Shlipak, Prabin Shrestha, Zean Song, Natalie Staplin, Dominik Steubl, Priya Vart, Frank L. J. Visseren, Mark Woodward, Kazumasa Yamagishi, Bessie A. Young, Charumathi Sabanayagam, Jose M. Valdivielso, Unknown, Unknown, John Chalmers, Katie Harris, Unknown, Hiroshi Yatsuya, Yuanying Li, Midori Takada, Unknown, Unknown, Steven Chadban, Unknown, Bruce Neal, Unknown, Unknown, Unknown, Isao Muraki, Hironori Imano, Hiroyasu Iso, Unknown, Natalia Alencar de Pinho, Ziad Massy, Benedicte Stengel, Marie Metzger, Unknown, Kenneth W. Mahaffey, Meg Jardine, Vlado Perkovic, Unknown, Matthew Weir, Jing Chen, James Lash, Panduranga Rao, Unknown, Unknown, Colby Ayers, Amit Khera, Parag Joshi, Amil Shah, Unknown, Michael J. Pencina, Matthew Engelhard, Mu Niu, Haoyuan Wang, Unknown, Paula Bracco, Maria de Jesus Mendes da Fonseca, Isabela Bensenor, Maria da Conceição Chagas de Almeida, Luana Giatti, Unknown, Richard Haynes, Parminder Judge, Unknown, Unknown, Ulla T. Schultheiss, Wibke Bechtel-Walz, Markus Schneider, Turgay Saritas, Unknown, Ewan Pearson, Colin Palmer, Shona J. Livingstone, Emilie Lambourg, Unknown, Serafi Cambray, Marcelino Bermudez-Lopez, Maria Luisa Martin-Conde, Maite Caus, Unknown, Unknown, Unknown, Nigel J. Brunskill, James F. Medcalf, Unknown, Jaclyn Bergstrom, Joachim Ix, Dena Rifkin, Unknown, Keiichi Sumida, Unknown, Orlando Gutierrez, Katharine Cheung, Titi Ilori, Unknown, Unknown, Ching Yu Cheng, Cancan Xue, Xiayin Zhang, Crystal Chong, Unknown, Colin Baigent, Martin Landray, Unknown, Rajkumar Chinnadurai, Smeeta Sinha, Sharmilee Rengarajan, Ivona Baricevic-Jones, Unknown, Robin W. M. Vernooij, Unknown, Unknown, Simon Benjamin Ascher, Unknown, Navdeep Tangri, Unknown, Unknown, Anders Larsson, Vilmantas Giedraitis

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DOI: 10.1038/s41591-026-04437-z
Published: 2026-05-05
Container: Nature Medicine
Publisher: Springer Science and Business Media LLC
Open access: unknown

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Cite this work

BibTeX

@article{allodium:10.1038/s41591-026-04437-z,
title = {Multinational validation of the PREVENT and SCORE2 cardiovascular risk equations across 6.4 million individuals},
author = {Brendon L. Neuen and Rupert W. Major and Morgan E. Grams and Yingying Sang and Josef Coresh and Shoshana H. Ballew and Aditya Surapaneni and Natalia Alencar de Pinho and Johan Ärnlöv and Clare Arnott and Samira Bell and Jarett Berry and Hermann Brenner and Elizabeth Ciemins and Alexander R. Chang and Mary Cushman and James A. de Lemos and Juan Miguel Diaz-Tocados and Alfredo E. Farjat and Robert A. Fletcher and Ron T. Gansevoort and Hiddo J. L. Heerspink and William G. Herrington and Chuan Hong and Edward J. Horwitz and Shih-Jen Hwang and Simerjot K. Jassal and Philip A. Kalra and Ronit Katz and Sadiya S. Khan and Csaba P. Kovesdy and Florian Kronenberg and Jennifer S. Lees and Donald M. Lloyd-Jones and Jose Geraldo Mill and David M. J. Naimark and Chiadi Ndumele and Kevan R. Polkinghorne and Bruce M. Psaty and Patrick Schloemer and Michael G. Shlipak and Prabin Shrestha and Zean Song and Natalie Staplin and Dominik Steubl and Priya Vart and Frank L. J. Visseren and Mark Woodward and Kazumasa Yamagishi and Bessie A. Young and Charumathi Sabanayagam and Jose M. Valdivielso and Unknown and Unknown and John Chalmers and Katie Harris and Unknown and Hiroshi Yatsuya and Yuanying Li and Midori Takada and Unknown and Unknown and Steven Chadban and Unknown and Bruce Neal and Unknown and Unknown and Unknown and Isao Muraki and Hironori Imano and Hiroyasu Iso and Unknown and Natalia Alencar de Pinho and Ziad Massy and Benedicte Stengel and Marie Metzger and Unknown and Kenneth W. Mahaffey and Meg Jardine and Vlado Perkovic and Unknown and Matthew Weir and Jing Chen and James Lash and Panduranga Rao and Unknown and Unknown and Colby Ayers and Amit Khera and Parag Joshi and Amil Shah and Unknown and Michael J. Pencina and Matthew Engelhard and Mu Niu and Haoyuan Wang and Unknown and Paula Bracco and Maria de Jesus Mendes da Fonseca and Isabela Bensenor and Maria da Conceição Chagas de Almeida and Luana Giatti and Unknown and Richard Haynes and Parminder Judge and Unknown and Unknown and Ulla T. Schultheiss and Wibke Bechtel-Walz and Markus Schneider and Turgay Saritas and Unknown and Ewan Pearson and Colin Palmer and Shona J. Livingstone and Emilie Lambourg and Unknown and Serafi Cambray and Marcelino Bermudez-Lopez and Maria Luisa Martin-Conde and Maite Caus and Unknown and Unknown and Unknown and Nigel J. Brunskill and James F. Medcalf and Unknown and Jaclyn Bergstrom and Joachim Ix and Dena Rifkin and Unknown and Keiichi Sumida and Unknown and Orlando Gutierrez and Katharine Cheung and Titi Ilori and Unknown and Unknown and Ching Yu Cheng and Cancan Xue and Xiayin Zhang and Crystal Chong and Unknown and Colin Baigent and Martin Landray and Unknown and Rajkumar Chinnadurai and Smeeta Sinha and Sharmilee Rengarajan and Ivona Baricevic-Jones and Unknown and Robin W. M. Vernooij and Unknown and Unknown and Simon Benjamin Ascher and Unknown and Navdeep Tangri and Unknown and Unknown and Anders Larsson and Vilmantas Giedraitis},
year = {2026},
journal = {Nature Medicine},
doi = {10.1038/s41591-026-04437-z},
url = {https://doi.org/10.1038/s41591-026-04437-z}
}

RIS

TY  - JOUR
TI  - Multinational validation of the PREVENT and SCORE2 cardiovascular risk equations across 6.4 million individuals
AU  - Brendon L. Neuen
AU  - Rupert W. Major
AU  - Morgan E. Grams
AU  - Yingying Sang
AU  - Josef Coresh
AU  - Shoshana H. Ballew
AU  - Aditya Surapaneni
AU  - Natalia Alencar de Pinho
AU  - Johan Ärnlöv
AU  - Clare Arnott
AU  - Samira Bell
AU  - Jarett Berry
AU  - Hermann Brenner
AU  - Elizabeth Ciemins
AU  - Alexander R. Chang
AU  - Mary Cushman
AU  - James A. de Lemos
AU  - Juan Miguel Diaz-Tocados
AU  - Alfredo E. Farjat
AU  - Robert A. Fletcher
AU  - Ron T. Gansevoort
AU  - Hiddo J. L. Heerspink
AU  - William G. Herrington
AU  - Chuan Hong
AU  - Edward J. Horwitz
AU  - Shih-Jen Hwang
AU  - Simerjot K. Jassal
AU  - Philip A. Kalra
AU  - Ronit Katz
AU  - Sadiya S. Khan
AU  - Csaba P. Kovesdy
AU  - Florian Kronenberg
AU  - Jennifer S. Lees
AU  - Donald M. Lloyd-Jones
AU  - Jose Geraldo Mill
AU  - David M. J. Naimark
AU  - Chiadi Ndumele
AU  - Kevan R. Polkinghorne
AU  - Bruce M. Psaty
AU  - Patrick Schloemer
AU  - Michael G. Shlipak
AU  - Prabin Shrestha
AU  - Zean Song
AU  - Natalie Staplin
AU  - Dominik Steubl
AU  - Priya Vart
AU  - Frank L. J. Visseren
AU  - Mark Woodward
AU  - Kazumasa Yamagishi
AU  - Bessie A. Young
AU  - Charumathi Sabanayagam
AU  - Jose M. Valdivielso
AU  - Unknown
AU  - Unknown
AU  - John Chalmers
AU  - Katie Harris
AU  - Unknown
AU  - Hiroshi Yatsuya
AU  - Yuanying Li
AU  - Midori Takada
AU  - Unknown
AU  - Unknown
AU  - Steven Chadban
AU  - Unknown
AU  - Bruce Neal
AU  - Unknown
AU  - Unknown
AU  - Unknown
AU  - Isao Muraki
AU  - Hironori Imano
AU  - Hiroyasu Iso
AU  - Unknown
AU  - Natalia Alencar de Pinho
AU  - Ziad Massy
AU  - Benedicte Stengel
AU  - Marie Metzger
AU  - Unknown
AU  - Kenneth W. Mahaffey
AU  - Meg Jardine
AU  - Vlado Perkovic
AU  - Unknown
AU  - Matthew Weir
AU  - Jing Chen
AU  - James Lash
AU  - Panduranga Rao
AU  - Unknown
AU  - Unknown
AU  - Colby Ayers
AU  - Amit Khera
AU  - Parag Joshi
AU  - Amil Shah
AU  - Unknown
AU  - Michael J. Pencina
AU  - Matthew Engelhard
AU  - Mu Niu
AU  - Haoyuan Wang
AU  - Unknown
AU  - Paula Bracco
AU  - Maria de Jesus Mendes da Fonseca
AU  - Isabela Bensenor
AU  - Maria da Conceição Chagas de Almeida
AU  - Luana Giatti
AU  - Unknown
AU  - Richard Haynes
AU  - Parminder Judge
AU  - Unknown
AU  - Unknown
AU  - Ulla T. Schultheiss
AU  - Wibke Bechtel-Walz
AU  - Markus Schneider
AU  - Turgay Saritas
AU  - Unknown
AU  - Ewan Pearson
AU  - Colin Palmer
AU  - Shona J. Livingstone
AU  - Emilie Lambourg
AU  - Unknown
AU  - Serafi Cambray
AU  - Marcelino Bermudez-Lopez
AU  - Maria Luisa Martin-Conde
AU  - Maite Caus
AU  - Unknown
AU  - Unknown
AU  - Unknown
AU  - Nigel J. Brunskill
AU  - James F. Medcalf
AU  - Unknown
AU  - Jaclyn Bergstrom
AU  - Joachim Ix
AU  - Dena Rifkin
AU  - Unknown
AU  - Keiichi Sumida
AU  - Unknown
AU  - Orlando Gutierrez
AU  - Katharine Cheung
AU  - Titi Ilori
AU  - Unknown
AU  - Unknown
AU  - Ching Yu Cheng
AU  - Cancan Xue
AU  - Xiayin Zhang
AU  - Crystal Chong
AU  - Unknown
AU  - Colin Baigent
AU  - Martin Landray
AU  - Unknown
AU  - Rajkumar Chinnadurai
AU  - Smeeta Sinha
AU  - Sharmilee Rengarajan
AU  - Ivona Baricevic-Jones
AU  - Unknown
AU  - Robin W. M. Vernooij
AU  - Unknown
AU  - Unknown
AU  - Simon Benjamin Ascher
AU  - Unknown
AU  - Navdeep Tangri
AU  - Unknown
AU  - Unknown
AU  - Anders Larsson
AU  - Vilmantas Giedraitis
PY  - 2026
JO  - Nature Medicine
DO  - 10.1038/s41591-026-04437-z
UR  - https://doi.org/10.1038/s41591-026-04437-z
ER  -

APA

Neuen, B. L., Major, R. W., Grams, M. E., Sang, Y., Coresh, J., Ballew, S. H., Surapaneni, A., Pinho, N. A. D., Ärnlöv, J., Arnott, C., Bell, S., Berry, J., Brenner, H., Ciemins, E., Chang, A. R., Cushman, M., Lemos, J. A. D., Diaz-Tocados, J. M., Farjat, A. E., Fletcher, R. A., Gansevoort, R. T., Heerspink, H. J. L., Herrington, W. G., Hong, C., Horwitz, E. J., Hwang, S., Jassal, S. K., Kalra, P. A., Katz, R., Khan, S. S., Kovesdy, C. P., Kronenberg, F., Lees, J. S., Lloyd-Jones, D. M., Mill, J. G., Naimark, D. M. J., Ndumele, C., Polkinghorne, K. R., Psaty, B. M., Schloemer, P., Shlipak, M. G., Shrestha, P., Song, Z., Staplin, N., Steubl, D., Vart, P., Visseren, F. L. J., Woodward, M., Yamagishi, K., Young, B. A., Sabanayagam, C., Valdivielso, J. M., Unknown, Unknown, Chalmers, J., Harris, K., Unknown, Yatsuya, H., Li, Y., Takada, M., Unknown, Unknown, Chadban, S., Unknown, Neal, B., Unknown, Unknown, Unknown, Muraki, I., Imano, H., Iso, H., Unknown, Pinho, N. A. D., Massy, Z., Stengel, B., Metzger, M., Unknown, Mahaffey, K. W., Jardine, M., Perkovic, V., Unknown, Weir, M., Chen, J., Lash, J., Rao, P., Unknown, Unknown, Ayers, C., Khera, A., Joshi, P., Shah, A., Unknown, Pencina, M. J., Engelhard, M., Niu, M., Wang, H., Unknown, Bracco, P., Fonseca, M. D. J. M. D., Bensenor, I., Almeida, M. D. C. C. D., Giatti, L., Unknown, Haynes, R., Judge, P., Unknown, Unknown, Schultheiss, U. T., Bechtel-Walz, W., Schneider, M., Saritas, T., Unknown, Pearson, E., Palmer, C., Livingstone, S. J., Lambourg, E., Unknown, Cambray, S., Bermudez-Lopez, M., Martin-Conde, M. L., Caus, M., Unknown, Unknown, Unknown, Brunskill, N. J., Medcalf, J. F., Unknown, Bergstrom, J., Ix, J., Rifkin, D., Unknown, Sumida, K., Unknown, Gutierrez, O., Cheung, K., Ilori, T., Unknown, Unknown, Cheng, C. Y., Xue, C., Zhang, X., Chong, C., Unknown, Baigent, C., Landray, M., Unknown, Chinnadurai, R., Sinha, S., Rengarajan, S., Baricevic-Jones, I., Unknown, Vernooij, R. W. M., Unknown, Unknown, Ascher, S. B., Unknown, Tangri, N., Unknown, Unknown, Larsson, A., & Giedraitis, V. (2026). Multinational validation of the PREVENT and SCORE2 cardiovascular risk equations across 6.4 million individuals. Nature Medicine. https://doi.org/10.1038/s41591-026-04437-z

Source records

crossref · retrieved 2026-11-06T02:10:48.294Z