Oral KRAS G12D inhibitor GFH375 for previously treated advanced solid tumors with KRASG12D mutations: a phase 1 trial

Xinghao Ai, Zhengbo Song, Lin Wu, Aiping Zhou, Di Cheng, Hong Zong, Heshui Wu, Zuoxing Niu, Yuping Sun, Lingjun Zhu, Zhiwei Li, Yanhong Deng, Ying Yuan, Xiujuan Qu, Haitao Zhao, Yingying Du, Ziming Li, Yu Wang, Haige Shen, Huaqiang Zhu, Chanli Zheng, Shuang Wang, Zhao Cui, Lingyu Tai, Shun Lu

Open source

DOI
10.1038/s41591-026-04559-4
Published
2026-09
Container
Nature Medicine
Publisher
Springer Science and Business Media LLC
Open access
unknown

Credibility signals

uncertain Score 64/100 under policy 1.0.0. This is a metadata assessment, not a judgment of the paper's conclusions.

Show all credibility signals

Cite this work

BibTeX

@article{allodium:10.1038/s41591-026-04559-4,
  title = {Oral KRAS G12D inhibitor GFH375 for previously treated advanced solid tumors with KRASG12D mutations: a phase 1 trial},
  author = {Xinghao Ai and Zhengbo Song and Lin Wu and Aiping Zhou and Di Cheng and Hong Zong and Heshui Wu and Zuoxing Niu and Yuping Sun and Lingjun Zhu and Zhiwei Li and Yanhong Deng and Ying Yuan and Xiujuan Qu and Haitao Zhao and Yingying Du and Ziming Li and Yu Wang and Haige Shen and Huaqiang Zhu and Chanli Zheng and Shuang Wang and Zhao Cui and Lingyu Tai and Shun Lu},
  year = {2026},
  journal = {Nature Medicine},
  doi = {10.1038/s41591-026-04559-4},
  url = {https://doi.org/10.1038/s41591-026-04559-4}
}

RIS

TY  - JOUR
TI  - Oral KRAS G12D inhibitor GFH375 for previously treated advanced solid tumors with KRASG12D mutations: a phase 1 trial
AU  - Xinghao Ai
AU  - Zhengbo Song
AU  - Lin Wu
AU  - Aiping Zhou
AU  - Di Cheng
AU  - Hong Zong
AU  - Heshui Wu
AU  - Zuoxing Niu
AU  - Yuping Sun
AU  - Lingjun Zhu
AU  - Zhiwei Li
AU  - Yanhong Deng
AU  - Ying Yuan
AU  - Xiujuan Qu
AU  - Haitao Zhao
AU  - Yingying Du
AU  - Ziming Li
AU  - Yu Wang
AU  - Haige Shen
AU  - Huaqiang Zhu
AU  - Chanli Zheng
AU  - Shuang Wang
AU  - Zhao Cui
AU  - Lingyu Tai
AU  - Shun Lu
PY  - 2026
JO  - Nature Medicine
DO  - 10.1038/s41591-026-04559-4
UR  - https://doi.org/10.1038/s41591-026-04559-4
ER  - 

APA

Ai, X., Song, Z., Wu, L., Zhou, A., Cheng, D., Zong, H., Wu, H., Niu, Z., Sun, Y., Zhu, L., Li, Z., Deng, Y., Yuan, Y., Qu, X., Zhao, H., Du, Y., Li, Z., Wang, Y., Shen, H., Zhu, H., Zheng, C., Wang, S., Cui, Z., Tai, L., & Lu, S. (2026). Oral KRAS G12D inhibitor GFH375 for previously treated advanced solid tumors with KRASG12D mutations: a phase 1 trial. Nature Medicine. https://doi.org/10.1038/s41591-026-04559-4

Source records