Neoadjuvant botensilimab with or without balstilimab in pMMR and dMMR colon cancer: the phase 2 UNICORN trial

Filippo Ghelardi, Margherita Ambrosini, Alessandra Raimondi, Andrei Tyshevich, Federica Palermo, Francesca Bergamo, Vincenzo Nasca, Paolo Manca, Ilaria Mulas, Lisa Derosa, Gina Brown, Claudia Chiodoni, Massimo Di Maio, Samantha Di Donato, Anna Chiaramonte, Lorenzo Castagnoli, Stephanie Ni, Darryl Nousome, Erik Spickard, Antony Tin, Robert Lentz, Adham Jurdi, Giovanna Sabella, Daniele Spada, Stefano Tamberi, Alessandro Passardi, Federica Morano, Emiliano Tamburini, Chiara Rossi, Luca Azzolin, Francesco Cambuli, Antonia Martinetti, Elisa Sottotetti, Andrew Allan Almonte, Valerio Iebba, Chiara Ratti, Riccardo Cerantola, Özlem Kutlu, Eleonora Cristarella, Serenella M. Pupa, Cecilia Villa, Eleonora Perissinotto, Margherita Galassi, Andrea Barina, Fabrizio Vittadello, Marcello Guaglio, Gianluca Baiocchi, Andrea Sartore-Bianchi, Riccardo Rosati, Chiara Cremolini, Isacco Montroni, Sara Lonardi, Andrea Sottoriva, Filippo Pietrantonio

Open source

DOI: 10.1038/s41591-026-04710-1
Published: 2026-11-02
Container: Nature Medicine
Publisher: Springer Science and Business Media LLC
Open access: unknown

Credibility signals

uncertain Score 64/100 under policy 1.0.0. This is a metadata assessment, not a judgment of the paper's conclusions.

Show all credibility signals

supportingDOI registered: A matching record was returned by Crossref. Source: Crossref; license: CC0 metadata
supportingDOI resolves: A matching record was returned by Crossref. Source: Crossref; license: CC0 metadata
not scoredDirectory of Open Access Journals: No matching DOAJ record was present in this response. No allow-list match; this is not evidence of low credibility. Source: DOAJ; license: CC0
not scoredMEDLINE indexed: Not checked or no result supplied; no credibility inference made. Source: No authority result supplied; license: Unknown
not scoredOpenAlex core source: Not checked or no result supplied; no credibility inference made. Source: No authority result supplied; license: Unknown
not scoredKnown publisher allow-list: Not checked or no result supplied; no credibility inference made. Source: No authority result supplied; license: Unknown
not scoredROR affiliation: Not checked or no result supplied; no credibility inference made. Source: No authority result supplied; license: Unknown
not scoredRetraction Watch retraction: No retraction notice matched this DOI in the deployed snapshot. No matching event found; coverage may be incomplete. Source: Retraction Watch; license: CC BY 4.0
not scoredRetraction Watch expression of concern: No expression of concern notice matched this DOI in the deployed snapshot. No matching event found; coverage may be incomplete. Source: Retraction Watch; license: CC BY 4.0
not scoredRetraction Watch correction: No correction notice matched this DOI in the deployed snapshot. No matching event found; coverage may be incomplete. Source: Retraction Watch; license: CC BY 4.0
not scoredRetraction Watch reinstatement: No reinstatement notice matched this DOI in the deployed snapshot. No matching event found; coverage may be incomplete. Source: Retraction Watch; license: CC BY 4.0
not scoredOpen access status: Not checked or no result supplied; no credibility inference made. Source: No authority result supplied; license: Unknown
not scoredPublication license: Not checked or no result supplied; no credibility inference made. Source: No authority result supplied; license: Unknown
not scoredPublication version: A publication version was supplied but is not scored. Source: Normalized work metadata; license: Caller-provided; provenance license not supplied to scorer
supportingMetadata completeness: All 6 scored descriptive metadata groups are present. Source: Normalized work metadata; license: Caller-provided; provenance license not supplied to scorer

Cite this work

BibTeX

@article{allodium:10.1038/s41591-026-04710-1,
  title = {Neoadjuvant botensilimab with or without balstilimab in pMMR and dMMR colon cancer: the phase 2 UNICORN trial},
  author = {Filippo Ghelardi and Margherita Ambrosini and Alessandra Raimondi and Andrei Tyshevich and Federica Palermo and Francesca Bergamo and Vincenzo Nasca and Paolo Manca and Ilaria Mulas and Lisa Derosa and Gina Brown and Claudia Chiodoni and Massimo Di Maio and Samantha Di Donato and Anna Chiaramonte and Lorenzo Castagnoli and Stephanie Ni and Darryl Nousome and Erik Spickard and Antony Tin and Robert Lentz and Adham Jurdi and Giovanna Sabella and Daniele Spada and Stefano Tamberi and Alessandro Passardi and Federica Morano and Emiliano Tamburini and Chiara Rossi and Luca Azzolin and Francesco Cambuli and Antonia Martinetti and Elisa Sottotetti and Andrew Allan Almonte and Valerio Iebba and Chiara Ratti and Riccardo Cerantola and Özlem Kutlu and Eleonora Cristarella and Serenella M. Pupa and Cecilia Villa and Eleonora Perissinotto and Margherita Galassi and Andrea Barina and Fabrizio Vittadello and Marcello Guaglio and Gianluca Baiocchi and Andrea Sartore-Bianchi and Riccardo Rosati and Chiara Cremolini and Isacco Montroni and Sara Lonardi and Andrea Sottoriva and Filippo Pietrantonio},
  year = {2026},
  journal = {Nature Medicine},
  doi = {10.1038/s41591-026-04710-1},
  url = {https://doi.org/10.1038/s41591-026-04710-1}
}

RIS

TY  - JOUR
TI  - Neoadjuvant botensilimab with or without balstilimab in pMMR and dMMR colon cancer: the phase 2 UNICORN trial
AU  - Filippo Ghelardi
AU  - Margherita Ambrosini
AU  - Alessandra Raimondi
AU  - Andrei Tyshevich
AU  - Federica Palermo
AU  - Francesca Bergamo
AU  - Vincenzo Nasca
AU  - Paolo Manca
AU  - Ilaria Mulas
AU  - Lisa Derosa
AU  - Gina Brown
AU  - Claudia Chiodoni
AU  - Massimo Di Maio
AU  - Samantha Di Donato
AU  - Anna Chiaramonte
AU  - Lorenzo Castagnoli
AU  - Stephanie Ni
AU  - Darryl Nousome
AU  - Erik Spickard
AU  - Antony Tin
AU  - Robert Lentz
AU  - Adham Jurdi
AU  - Giovanna Sabella
AU  - Daniele Spada
AU  - Stefano Tamberi
AU  - Alessandro Passardi
AU  - Federica Morano
AU  - Emiliano Tamburini
AU  - Chiara Rossi
AU  - Luca Azzolin
AU  - Francesco Cambuli
AU  - Antonia Martinetti
AU  - Elisa Sottotetti
AU  - Andrew Allan Almonte
AU  - Valerio Iebba
AU  - Chiara Ratti
AU  - Riccardo Cerantola
AU  - Özlem Kutlu
AU  - Eleonora Cristarella
AU  - Serenella M. Pupa
AU  - Cecilia Villa
AU  - Eleonora Perissinotto
AU  - Margherita Galassi
AU  - Andrea Barina
AU  - Fabrizio Vittadello
AU  - Marcello Guaglio
AU  - Gianluca Baiocchi
AU  - Andrea Sartore-Bianchi
AU  - Riccardo Rosati
AU  - Chiara Cremolini
AU  - Isacco Montroni
AU  - Sara Lonardi
AU  - Andrea Sottoriva
AU  - Filippo Pietrantonio
PY  - 2026
JO  - Nature Medicine
DO  - 10.1038/s41591-026-04710-1
UR  - https://doi.org/10.1038/s41591-026-04710-1
ER  -

APA

Ghelardi, F., Ambrosini, M., Raimondi, A., Tyshevich, A., Palermo, F., Bergamo, F., Nasca, V., Manca, P., Mulas, I., Derosa, L., Brown, G., Chiodoni, C., Maio, M. D., Donato, S. D., Chiaramonte, A., Castagnoli, L., Ni, S., Nousome, D., Spickard, E., Tin, A., Lentz, R., Jurdi, A., Sabella, G., Spada, D., Tamberi, S., Passardi, A., Morano, F., Tamburini, E., Rossi, C., Azzolin, L., Cambuli, F., Martinetti, A., Sottotetti, E., Almonte, A. A., Iebba, V., Ratti, C., Cerantola, R., Kutlu, Ö., Cristarella, E., Pupa, S. M., Villa, C., Perissinotto, E., Galassi, M., Barina, A., Vittadello, F., Guaglio, M., Baiocchi, G., Sartore-Bianchi, A., Rosati, R., Cremolini, C., Montroni, I., Lonardi, S., Sottoriva, A., & Pietrantonio, F. (2026). Neoadjuvant botensilimab with or without balstilimab in pMMR and dMMR colon cancer: the phase 2 UNICORN trial. Nature Medicine. https://doi.org/10.1038/s41591-026-04710-1

Source records

crossref · retrieved 2026-11-05T03:55:07.835Z