cellSTAAR: incorporating single-cell-sequencing-based functional data to boost power in rare variant association testing of noncoding regions.

Van Buren E, Zhang Y, Li X, Selvaraj MS, Li Z, Zhou H, Palmer ND, Arnett DK, Blangero J, Boerwinkle E, Cade BE, Carlson JC, Carson AP, Chen YI, Curran J, Duggirala R, Fornage M, Franceschini N, Graff M, Gu C, Guo X, He J, Heard-Cosa N, Hou L, Hung YJ, Kalyani RR, Kardia SLR, Kenny E, Kooperberg C, Kral BG, Lange L, Levy D, Li C, Liu S, Lloyd-Jones D, Loos RJF, Manichaikul AW, Martin LW, Mathias R, Minster RL, Mitchell BD, Mychaleckyj JC, Naseri T, North K, O'Connell J, Perry JA, Peyser PA, Psaty BM, Raffield LM, Vasan RS, Redline S, Reiner AP, Rich SS, Smith JA, Spitzer B, Tang H, Taylor KD, Tracy R, Viali S, Yanek L, Zhao W, NHLBI Trans-Omics for Precision Medicine (TOPMed) Consortium, Rotter JI, Peloso GM, Natarajan P, Lin X

Open source

DOI
10.1038/s41592-025-02919-5
Published
2026 Feb
Container
Nature methods
Publisher
Not recorded
Open access
yes

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BibTeX

@article{allodium:10.1038/s41592-025-02919-5,
  title = {cellSTAAR: incorporating single-cell-sequencing-based functional data to boost power in rare variant association testing of noncoding regions.},
  author = {Van Buren E and Zhang Y and Li X and Selvaraj MS and Li Z and Zhou H and Palmer ND and Arnett DK and Blangero J and Boerwinkle E and Cade BE and Carlson JC and Carson AP and Chen YI and Curran J and Duggirala R and Fornage M and Franceschini N and Graff M and Gu C and Guo X and He J and Heard-Cosa N and Hou L and Hung YJ and Kalyani RR and Kardia SLR and Kenny E and Kooperberg C and Kral BG and Lange L and Levy D and Li C and Liu S and Lloyd-Jones D and Loos RJF and Manichaikul AW and Martin LW and Mathias R and Minster RL and Mitchell BD and Mychaleckyj JC and Naseri T and North K and O'Connell J and Perry JA and Peyser PA and Psaty BM and Raffield LM and Vasan RS and Redline S and Reiner AP and Rich SS and Smith JA and Spitzer B and Tang H and Taylor KD and Tracy R and Viali S and Yanek L and Zhao W and NHLBI Trans-Omics for Precision Medicine (TOPMed) Consortium and Rotter JI and Peloso GM and Natarajan P and Lin X},
  year = {2026},
  journal = {Nature methods},
  doi = {10.1038/s41592-025-02919-5},
  url = {https://doi.org/10.1038/s41592-025-02919-5}
}

RIS

TY  - JOUR
TI  - cellSTAAR: incorporating single-cell-sequencing-based functional data to boost power in rare variant association testing of noncoding regions.
AU  - Van Buren E
AU  - Zhang Y
AU  - Li X
AU  - Selvaraj MS
AU  - Li Z
AU  - Zhou H
AU  - Palmer ND
AU  - Arnett DK
AU  - Blangero J
AU  - Boerwinkle E
AU  - Cade BE
AU  - Carlson JC
AU  - Carson AP
AU  - Chen YI
AU  - Curran J
AU  - Duggirala R
AU  - Fornage M
AU  - Franceschini N
AU  - Graff M
AU  - Gu C
AU  - Guo X
AU  - He J
AU  - Heard-Cosa N
AU  - Hou L
AU  - Hung YJ
AU  - Kalyani RR
AU  - Kardia SLR
AU  - Kenny E
AU  - Kooperberg C
AU  - Kral BG
AU  - Lange L
AU  - Levy D
AU  - Li C
AU  - Liu S
AU  - Lloyd-Jones D
AU  - Loos RJF
AU  - Manichaikul AW
AU  - Martin LW
AU  - Mathias R
AU  - Minster RL
AU  - Mitchell BD
AU  - Mychaleckyj JC
AU  - Naseri T
AU  - North K
AU  - O'Connell J
AU  - Perry JA
AU  - Peyser PA
AU  - Psaty BM
AU  - Raffield LM
AU  - Vasan RS
AU  - Redline S
AU  - Reiner AP
AU  - Rich SS
AU  - Smith JA
AU  - Spitzer B
AU  - Tang H
AU  - Taylor KD
AU  - Tracy R
AU  - Viali S
AU  - Yanek L
AU  - Zhao W
AU  - NHLBI Trans-Omics for Precision Medicine (TOPMed) Consortium
AU  - Rotter JI
AU  - Peloso GM
AU  - Natarajan P
AU  - Lin X
PY  - 2026
JO  - Nature methods
DO  - 10.1038/s41592-025-02919-5
UR  - https://doi.org/10.1038/s41592-025-02919-5
ER  -

APA

E, V. B., Y, Z., X, L., MS, S., Z, L., H, Z., ND, P., DK, A., J, B., E, B., BE, C., JC, C., AP, C., YI, C., J, C., R, D., M, F., N, F., M, G., C, G., X, G., J, H., N, H., L, H., YJ, H., RR, K., SLR, K., E, K., C, K., BG, K., L, L., D, L., C, L., S, L., D, L., RJF, L., AW, M., LW, M., R, M., RL, M., BD, M., JC, M., T, N., K, N., J, O., JA, P., PA, P., BM, P., LM, R., RS, V., S, R., AP, R., SS, R., JA, S., B, S., H, T., KD, T., R, T., S, V., L, Y., W, Z., Consortium, N. T. F. P. M. (., JI, R., GM, P., P, N., & X, L. (2026). cellSTAAR: incorporating single-cell-sequencing-based functional data to boost power in rare variant association testing of noncoding regions.. Nature methods. https://doi.org/10.1038/s41592-025-02919-5

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