TDP-43-dependent mis-splicing of KCNQ2 triggers intrinsic neuronal hyperexcitability in ALS/FTD.

Joseph BJ, Marshall KA, Harley P, Mann JR, Alessandrini F, Vanoye CG, Chi W, Prudencio M, Simkin D, Kao TT, Desai RR, Keuss MJ, Barattucci S, Zanovello M, Mehta PR, DeKeyser JM, Limone F, Lee J, Brown AL, Leyton-Jaimes MF, Nash LA, Juan IGS, Aronica E, Wainger BJ, Shah M, Goswami A, Shneider NA, Dickson DW, Burrone J, Zhang C, Wichterle H, Petrucelli L, Watts JK, George AL Jr, Fratta P, Eggan K, Kiskinis E

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DOI: 10.1038/s41593-025-02096-w
Published: 2025 Dec
Container: Nature neuroscience
Publisher: Not recorded
Open access: yes

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Cite this work

BibTeX

@article{allodium:10.1038/s41593-025-02096-w,
  title = {TDP-43-dependent mis-splicing of KCNQ2 triggers intrinsic neuronal hyperexcitability in ALS/FTD.},
  author = {Joseph BJ and Marshall KA and Harley P and Mann JR and Alessandrini F and Vanoye CG and Chi W and Prudencio M and Simkin D and Kao TT and Desai RR and Keuss MJ and Barattucci S and Zanovello M and Mehta PR and DeKeyser JM and Limone F and Lee J and Brown AL and Leyton-Jaimes MF and Nash LA and Juan IGS and Aronica E and Wainger BJ and Shah M and Goswami A and Shneider NA and Dickson DW and Burrone J and Zhang C and Wichterle H and Petrucelli L and Watts JK and George AL Jr and Fratta P and Eggan K and Kiskinis E},
  year = {2025},
  journal = {Nature neuroscience},
  doi = {10.1038/s41593-025-02096-w},
  url = {https://doi.org/10.1038/s41593-025-02096-w}
}

RIS

TY  - JOUR
TI  - TDP-43-dependent mis-splicing of KCNQ2 triggers intrinsic neuronal hyperexcitability in ALS/FTD.
AU  - Joseph BJ
AU  - Marshall KA
AU  - Harley P
AU  - Mann JR
AU  - Alessandrini F
AU  - Vanoye CG
AU  - Chi W
AU  - Prudencio M
AU  - Simkin D
AU  - Kao TT
AU  - Desai RR
AU  - Keuss MJ
AU  - Barattucci S
AU  - Zanovello M
AU  - Mehta PR
AU  - DeKeyser JM
AU  - Limone F
AU  - Lee J
AU  - Brown AL
AU  - Leyton-Jaimes MF
AU  - Nash LA
AU  - Juan IGS
AU  - Aronica E
AU  - Wainger BJ
AU  - Shah M
AU  - Goswami A
AU  - Shneider NA
AU  - Dickson DW
AU  - Burrone J
AU  - Zhang C
AU  - Wichterle H
AU  - Petrucelli L
AU  - Watts JK
AU  - George AL Jr
AU  - Fratta P
AU  - Eggan K
AU  - Kiskinis E
PY  - 2025
JO  - Nature neuroscience
DO  - 10.1038/s41593-025-02096-w
UR  - https://doi.org/10.1038/s41593-025-02096-w
ER  -

APA

BJ, J., KA, M., P, H., JR, M., F, A., CG, V., W, C., M, P., D, S., TT, K., RR, D., MJ, K., S, B., M, Z., PR, M., JM, D., F, L., J, L., AL, B., MF, L., LA, N., IGS, J., E, A., BJ, W., M, S., A, G., NA, S., DW, D., J, B., C, Z., H, W., L, P., JK, W., Jr, G. A., P, F., K, E., & E, K. (2025). TDP-43-dependent mis-splicing of KCNQ2 triggers intrinsic neuronal hyperexcitability in ALS/FTD.. Nature neuroscience. https://doi.org/10.1038/s41593-025-02096-w

Source records

pubmed · retrieved 2026-09-26T14:13:37.009Z