Integrated single-cell and spatial transcriptomic profiling in ALS uncovers peripheral-to-central immune infiltration and reprogramming

Ziyang Zhang, Lynn van Olst, Francesco Alessandrini, Matthew Wright, Alex J. Edwards, Jake Boles, Anait Nalbandian, Anne V. Forsyth, Nate Shepard, Thomas Watson, Evan Kaspi, Angeli Mittal, Joshua Kuruvilla, Natalie Piehl, Abhirami Ramakrishnan, Stanley Appel, Evangelos Kiskinis, David Gate

Open source

DOI
10.1038/s41593-026-02300-5
Published
2026-05-14
Container
Nature Neuroscience
Publisher
Springer Science and Business Media LLC
Open access
unknown

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BibTeX

@article{allodium:10.1038/s41593-026-02300-5,
  title = {Integrated single-cell and spatial transcriptomic profiling in ALS uncovers peripheral-to-central immune infiltration and reprogramming},
  author = {Ziyang Zhang and Lynn van Olst and Francesco Alessandrini and Matthew Wright and Alex J. Edwards and Jake Boles and Anait Nalbandian and Anne V. Forsyth and Nate Shepard and Thomas Watson and Evan Kaspi and Angeli Mittal and Joshua Kuruvilla and Natalie Piehl and Abhirami Ramakrishnan and Stanley Appel and Evangelos Kiskinis and David Gate},
  year = {2026},
  journal = {Nature Neuroscience},
  doi = {10.1038/s41593-026-02300-5},
  url = {https://doi.org/10.1038/s41593-026-02300-5}
}

RIS

TY  - JOUR
TI  - Integrated single-cell and spatial transcriptomic profiling in ALS uncovers peripheral-to-central immune infiltration and reprogramming
AU  - Ziyang Zhang
AU  - Lynn van Olst
AU  - Francesco Alessandrini
AU  - Matthew Wright
AU  - Alex J. Edwards
AU  - Jake Boles
AU  - Anait Nalbandian
AU  - Anne V. Forsyth
AU  - Nate Shepard
AU  - Thomas Watson
AU  - Evan Kaspi
AU  - Angeli Mittal
AU  - Joshua Kuruvilla
AU  - Natalie Piehl
AU  - Abhirami Ramakrishnan
AU  - Stanley Appel
AU  - Evangelos Kiskinis
AU  - David Gate
PY  - 2026
JO  - Nature Neuroscience
DO  - 10.1038/s41593-026-02300-5
UR  - https://doi.org/10.1038/s41593-026-02300-5
ER  - 

APA

Zhang, Z., Olst, L. V., Alessandrini, F., Wright, M., Edwards, A. J., Boles, J., Nalbandian, A., Forsyth, A. V., Shepard, N., Watson, T., Kaspi, E., Mittal, A., Kuruvilla, J., Piehl, N., Ramakrishnan, A., Appel, S., Kiskinis, E., & Gate, D. (2026). Integrated single-cell and spatial transcriptomic profiling in ALS uncovers peripheral-to-central immune infiltration and reprogramming. Nature Neuroscience. https://doi.org/10.1038/s41593-026-02300-5

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