Ectopic expression of cytosolic DHODH uncouples de novo pyrimidine biosynthesis from mitochondrial electron transport.

Curtabbi A, Jaroszewicz SN, Sanz-Cortés R, Acín-Pérez R, Prymidis D, Cherevatenko M, Martínez-de-Mena R, Esteban-Amo MJ, de la Fuente MA, Frezza C, Enríquez JA

Open source

DOI: 10.1038/s42255-026-01454-7
Published: 2026 Feb
Container: Nature metabolism
Publisher: Not recorded
Open access: yes

Credibility signals

limited evidence Score 45/100 under policy 1.0.0. This is a metadata assessment, not a judgment of the paper's conclusions.

Show all credibility signals

cautionDOI registered: No matching Crossref record was present in this response. Source: Crossref; license: CC0 metadata
cautionDOI resolves: No matching Crossref record was present in this response. Source: Crossref; license: CC0 metadata
not scoredDirectory of Open Access Journals: No matching DOAJ record was present in this response. No allow-list match; this is not evidence of low credibility. Source: DOAJ; license: CC0
not scoredMEDLINE indexed: Not checked or no result supplied; no credibility inference made. Source: No authority result supplied; license: Unknown
not scoredOpenAlex core source: Not checked or no result supplied; no credibility inference made. Source: No authority result supplied; license: Unknown
not scoredKnown publisher allow-list: Not checked or no result supplied; no credibility inference made. Source: No authority result supplied; license: Unknown
not scoredROR affiliation: Not checked or no result supplied; no credibility inference made. Source: No authority result supplied; license: Unknown
not scoredRetraction Watch retraction: No retraction notice matched this DOI in the deployed snapshot. No matching event found; coverage may be incomplete. Source: Retraction Watch; license: CC BY 4.0
not scoredRetraction Watch expression of concern: No expression of concern notice matched this DOI in the deployed snapshot. No matching event found; coverage may be incomplete. Source: Retraction Watch; license: CC BY 4.0
not scoredRetraction Watch correction: No correction notice matched this DOI in the deployed snapshot. No matching event found; coverage may be incomplete. Source: Retraction Watch; license: CC BY 4.0
not scoredRetraction Watch reinstatement: No reinstatement notice matched this DOI in the deployed snapshot. No matching event found; coverage may be incomplete. Source: Retraction Watch; license: CC BY 4.0
supportingOpen access status: Normalized open-access status: open. Source: Normalized work metadata; license: Caller-provided; provenance license not supplied to scorer
not scoredPublication license: Not checked or no result supplied; no credibility inference made. Source: No authority result supplied; license: Unknown
not scoredPublication version: A publication version was supplied but is not scored. Source: Normalized work metadata; license: Caller-provided; provenance license not supplied to scorer
cautionMetadata completeness: 5 of 6 scored descriptive metadata groups are present; missing fields increase uncertainty. Source: Normalized work metadata; license: Caller-provided; provenance license not supplied to scorer

Cite this work

BibTeX

@article{allodium:10.1038/s42255-026-01454-7,
  title = {Ectopic expression of cytosolic DHODH uncouples de novo pyrimidine biosynthesis from mitochondrial electron transport.},
  author = {Curtabbi A and Jaroszewicz SN and Sanz-Cortés R and Acín-Pérez R and Prymidis D and Cherevatenko M and Martínez-de-Mena R and Esteban-Amo MJ and de la Fuente MA and Frezza C and Enríquez JA},
  year = {2026},
  journal = {Nature metabolism},
  doi = {10.1038/s42255-026-01454-7},
  url = {https://doi.org/10.1038/s42255-026-01454-7}
}

RIS

TY  - JOUR
TI  - Ectopic expression of cytosolic DHODH uncouples de novo pyrimidine biosynthesis from mitochondrial electron transport.
AU  - Curtabbi A
AU  - Jaroszewicz SN
AU  - Sanz-Cortés R
AU  - Acín-Pérez R
AU  - Prymidis D
AU  - Cherevatenko M
AU  - Martínez-de-Mena R
AU  - Esteban-Amo MJ
AU  - de la Fuente MA
AU  - Frezza C
AU  - Enríquez JA
PY  - 2026
JO  - Nature metabolism
DO  - 10.1038/s42255-026-01454-7
UR  - https://doi.org/10.1038/s42255-026-01454-7
ER  -

APA

A, C., SN, J., R, S., R, A., D, P., M, C., R, M., MJ, E., MA, D. L. F., C, F., & JA, E. (2026). Ectopic expression of cytosolic DHODH uncouples de novo pyrimidine biosynthesis from mitochondrial electron transport.. Nature metabolism. https://doi.org/10.1038/s42255-026-01454-7

Source records

pubmed · retrieved 2026-11-10T14:04:07.541Z