A cellular and spatial atlas of TP53-associated tissue remodeling defines a multicellular tumor ecosystem in lung adenocarcinoma

William Zhao, Thinh T. Nguyen, Atharva Bhagwat, Akhil Kumar, Bruno Giotti, Benjamin Kepecs, Jason L. Weirather, Navin R. Mahadevan, Asa Segerstolpe, Komal Dolasia, Jamshid Abdul-Ghafar, Naomi R. Besson, Stephanie M. Jones, Brian Y. Soong, Chendi Li, Sebastien Vigneau, Michal Slyper, Isaac Wakiro, Mei-Ju Su, Karla Helvie, Allison Frangieh, Judit Jane-Valbuena, Orr Ashenberg, Mark Awad, Asaf Rotem, Raphael Bueno, Orit Rozenblatt-Rosen, Kathleen Pfaff, Scott Rodig, Aaron N. Hata, Aviv Regev, Bruce E. Johnson, Alexander M. Tsankov

Open source

DOI: 10.1038/s43018-025-01053-7
Published: 2025-10-07
Container: Nature Cancer
Publisher: Springer Science and Business Media LLC
Open access: unknown

Credibility signals

uncertain Score 64/100 under policy 1.0.0. This is a metadata assessment, not a judgment of the paper's conclusions.

Show all credibility signals

supportingDOI registered: A matching record was returned by Crossref. Source: Crossref; license: CC0 metadata
supportingDOI resolves: A matching record was returned by Crossref. Source: Crossref; license: CC0 metadata
not scoredDirectory of Open Access Journals: No matching DOAJ record was present in this response. No allow-list match; this is not evidence of low credibility. Source: DOAJ; license: CC0
not scoredMEDLINE indexed: Not checked or no result supplied; no credibility inference made. Source: No authority result supplied; license: Unknown
not scoredOpenAlex core source: Not checked or no result supplied; no credibility inference made. Source: No authority result supplied; license: Unknown
not scoredKnown publisher allow-list: Not checked or no result supplied; no credibility inference made. Source: No authority result supplied; license: Unknown
not scoredROR affiliation: Not checked or no result supplied; no credibility inference made. Source: No authority result supplied; license: Unknown
not scoredRetraction Watch retraction: No retraction notice matched this DOI in the deployed snapshot. No matching event found; coverage may be incomplete. Source: Retraction Watch; license: CC BY 4.0
not scoredRetraction Watch expression of concern: No expression of concern notice matched this DOI in the deployed snapshot. No matching event found; coverage may be incomplete. Source: Retraction Watch; license: CC BY 4.0
not scoredRetraction Watch correction: No correction notice matched this DOI in the deployed snapshot. No matching event found; coverage may be incomplete. Source: Retraction Watch; license: CC BY 4.0
not scoredRetraction Watch reinstatement: No reinstatement notice matched this DOI in the deployed snapshot. No matching event found; coverage may be incomplete. Source: Retraction Watch; license: CC BY 4.0
not scoredOpen access status: Not checked or no result supplied; no credibility inference made. Source: No authority result supplied; license: Unknown
not scoredPublication license: Not checked or no result supplied; no credibility inference made. Source: No authority result supplied; license: Unknown
not scoredPublication version: A publication version was supplied but is not scored. Source: Normalized work metadata; license: Caller-provided; provenance license not supplied to scorer
supportingMetadata completeness: All 6 scored descriptive metadata groups are present. Source: Normalized work metadata; license: Caller-provided; provenance license not supplied to scorer

Cite this work

BibTeX

@article{allodium:10.1038/s43018-025-01053-7,
  title = {A cellular and spatial atlas of TP53-associated tissue remodeling defines a multicellular tumor ecosystem in lung adenocarcinoma},
  author = {William Zhao and Thinh T. Nguyen and Atharva Bhagwat and Akhil Kumar and Bruno Giotti and Benjamin Kepecs and Jason L. Weirather and Navin R. Mahadevan and Asa Segerstolpe and Komal Dolasia and Jamshid Abdul-Ghafar and Naomi R. Besson and Stephanie M. Jones and Brian Y. Soong and Chendi Li and Sebastien Vigneau and Michal Slyper and Isaac Wakiro and Mei-Ju Su and Karla Helvie and Allison Frangieh and Judit Jane-Valbuena and Orr Ashenberg and Mark Awad and Asaf Rotem and Raphael Bueno and Orit Rozenblatt-Rosen and Kathleen Pfaff and Scott Rodig and Aaron N. Hata and Aviv Regev and Bruce E. Johnson and Alexander M. Tsankov},
  year = {2025},
  journal = {Nature Cancer},
  doi = {10.1038/s43018-025-01053-7},
  url = {https://doi.org/10.1038/s43018-025-01053-7}
}

RIS

TY  - JOUR
TI  - A cellular and spatial atlas of TP53-associated tissue remodeling defines a multicellular tumor ecosystem in lung adenocarcinoma
AU  - William Zhao
AU  - Thinh T. Nguyen
AU  - Atharva Bhagwat
AU  - Akhil Kumar
AU  - Bruno Giotti
AU  - Benjamin Kepecs
AU  - Jason L. Weirather
AU  - Navin R. Mahadevan
AU  - Asa Segerstolpe
AU  - Komal Dolasia
AU  - Jamshid Abdul-Ghafar
AU  - Naomi R. Besson
AU  - Stephanie M. Jones
AU  - Brian Y. Soong
AU  - Chendi Li
AU  - Sebastien Vigneau
AU  - Michal Slyper
AU  - Isaac Wakiro
AU  - Mei-Ju Su
AU  - Karla Helvie
AU  - Allison Frangieh
AU  - Judit Jane-Valbuena
AU  - Orr Ashenberg
AU  - Mark Awad
AU  - Asaf Rotem
AU  - Raphael Bueno
AU  - Orit Rozenblatt-Rosen
AU  - Kathleen Pfaff
AU  - Scott Rodig
AU  - Aaron N. Hata
AU  - Aviv Regev
AU  - Bruce E. Johnson
AU  - Alexander M. Tsankov
PY  - 2025
JO  - Nature Cancer
DO  - 10.1038/s43018-025-01053-7
UR  - https://doi.org/10.1038/s43018-025-01053-7
ER  -

APA

Zhao, W., Nguyen, T. T., Bhagwat, A., Kumar, A., Giotti, B., Kepecs, B., Weirather, J. L., Mahadevan, N. R., Segerstolpe, A., Dolasia, K., Abdul-Ghafar, J., Besson, N. R., Jones, S. M., Soong, B. Y., Li, C., Vigneau, S., Slyper, M., Wakiro, I., Su, M., Helvie, K., Frangieh, A., Jane-Valbuena, J., Ashenberg, O., Awad, M., Rotem, A., Bueno, R., Rozenblatt-Rosen, O., Pfaff, K., Rodig, S., Hata, A. N., Regev, A., Johnson, B. E., & Tsankov, A. M. (2025). A cellular and spatial atlas of TP53-associated tissue remodeling defines a multicellular tumor ecosystem in lung adenocarcinoma. Nature Cancer. https://doi.org/10.1038/s43018-025-01053-7

Source records

crossref · retrieved 2026-09-27T03:47:11.374Z