A statistical framework for multi-trait rare variant analysis in large-scale whole-genome sequencing studies.

Li X, Chen H, Selvaraj MS, Van Buren E, Zhou H, Wang Y, Sun R, McCaw ZR, Yu Z, Jiang MZ, DiCorpo D, Gaynor SM, Dey R, Arnett DK, Benjamin EJ, Bis JC, Blangero J, Boerwinkle E, Bowden DW, Brody JA, Cade BE, Carson AP, Carlson JC, Chami N, Chen YI, Curran JE, de Vries PS, Fornage M, Franceschini N, Freedman BI, Gu C, Heard-Costa NL, He J, Hou L, Hung YJ, Irvin MR, Kaplan RC, Kardia SLR, Kelly TN, Konigsberg I, Kooperberg C, Kral BG, Li C, Li Y, Lin H, Liu CT, Loos RJF, Mahaney MC, Martin LW, Mathias RA, Mitchell BD, Montasser ME, Morrison AC, Naseri T, North KE, Palmer ND, Peyser PA, Psaty BM, Redline S, Reiner AP, Rich SS, Sitlani CM, Smith JA, Taylor KD, Tiwari HK, Vasan RS, Viali S, Wang Z, Wessel J, Yanek LR, Yu B, NHLBI Trans-Omics for Precision Medicine (TOPMed) Consortium, Dupuis J, Meigs JB, Auer PL, Raffield LM, Manning AK, Rice KM, Rotter JI, Peloso GM, Natarajan P, Li Z, Liu Z, Lin X

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DOI: 10.1038/s43588-024-00764-8
Published: 2025 Feb
Container: Nature computational science
Publisher: Not recorded
Open access: yes

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Cite this work

BibTeX

@article{allodium:10.1038/s43588-024-00764-8,
  title = {A statistical framework for multi-trait rare variant analysis in large-scale whole-genome sequencing studies.},
  author = {Li X and Chen H and Selvaraj MS and Van Buren E and Zhou H and Wang Y and Sun R and McCaw ZR and Yu Z and Jiang MZ and DiCorpo D and Gaynor SM and Dey R and Arnett DK and Benjamin EJ and Bis JC and Blangero J and Boerwinkle E and Bowden DW and Brody JA and Cade BE and Carson AP and Carlson JC and Chami N and Chen YI and Curran JE and de Vries PS and Fornage M and Franceschini N and Freedman BI and Gu C and Heard-Costa NL and He J and Hou L and Hung YJ and Irvin MR and Kaplan RC and Kardia SLR and Kelly TN and Konigsberg I and Kooperberg C and Kral BG and Li C and Li Y and Lin H and Liu CT and Loos RJF and Mahaney MC and Martin LW and Mathias RA and Mitchell BD and Montasser ME and Morrison AC and Naseri T and North KE and Palmer ND and Peyser PA and Psaty BM and Redline S and Reiner AP and Rich SS and Sitlani CM and Smith JA and Taylor KD and Tiwari HK and Vasan RS and Viali S and Wang Z and Wessel J and Yanek LR and Yu B and NHLBI Trans-Omics for Precision Medicine (TOPMed) Consortium and Dupuis J and Meigs JB and Auer PL and Raffield LM and Manning AK and Rice KM and Rotter JI and Peloso GM and Natarajan P and Li Z and Liu Z and Lin X},
  year = {2025},
  journal = {Nature computational science},
  doi = {10.1038/s43588-024-00764-8},
  url = {https://doi.org/10.1038/s43588-024-00764-8}
}

RIS

TY  - JOUR
TI  - A statistical framework for multi-trait rare variant analysis in large-scale whole-genome sequencing studies.
AU  - Li X
AU  - Chen H
AU  - Selvaraj MS
AU  - Van Buren E
AU  - Zhou H
AU  - Wang Y
AU  - Sun R
AU  - McCaw ZR
AU  - Yu Z
AU  - Jiang MZ
AU  - DiCorpo D
AU  - Gaynor SM
AU  - Dey R
AU  - Arnett DK
AU  - Benjamin EJ
AU  - Bis JC
AU  - Blangero J
AU  - Boerwinkle E
AU  - Bowden DW
AU  - Brody JA
AU  - Cade BE
AU  - Carson AP
AU  - Carlson JC
AU  - Chami N
AU  - Chen YI
AU  - Curran JE
AU  - de Vries PS
AU  - Fornage M
AU  - Franceschini N
AU  - Freedman BI
AU  - Gu C
AU  - Heard-Costa NL
AU  - He J
AU  - Hou L
AU  - Hung YJ
AU  - Irvin MR
AU  - Kaplan RC
AU  - Kardia SLR
AU  - Kelly TN
AU  - Konigsberg I
AU  - Kooperberg C
AU  - Kral BG
AU  - Li C
AU  - Li Y
AU  - Lin H
AU  - Liu CT
AU  - Loos RJF
AU  - Mahaney MC
AU  - Martin LW
AU  - Mathias RA
AU  - Mitchell BD
AU  - Montasser ME
AU  - Morrison AC
AU  - Naseri T
AU  - North KE
AU  - Palmer ND
AU  - Peyser PA
AU  - Psaty BM
AU  - Redline S
AU  - Reiner AP
AU  - Rich SS
AU  - Sitlani CM
AU  - Smith JA
AU  - Taylor KD
AU  - Tiwari HK
AU  - Vasan RS
AU  - Viali S
AU  - Wang Z
AU  - Wessel J
AU  - Yanek LR
AU  - Yu B
AU  - NHLBI Trans-Omics for Precision Medicine (TOPMed) Consortium
AU  - Dupuis J
AU  - Meigs JB
AU  - Auer PL
AU  - Raffield LM
AU  - Manning AK
AU  - Rice KM
AU  - Rotter JI
AU  - Peloso GM
AU  - Natarajan P
AU  - Li Z
AU  - Liu Z
AU  - Lin X
PY  - 2025
JO  - Nature computational science
DO  - 10.1038/s43588-024-00764-8
UR  - https://doi.org/10.1038/s43588-024-00764-8
ER  -

APA

X, L., H, C., MS, S., E, V. B., H, Z., Y, W., R, S., ZR, M., Z, Y., MZ, J., D, D., SM, G., R, D., DK, A., EJ, B., JC, B., J, B., E, B., DW, B., JA, B., BE, C., AP, C., JC, C., N, C., YI, C., JE, C., PS, D. V., M, F., N, F., BI, F., C, G., NL, H., J, H., L, H., YJ, H., MR, I., RC, K., SLR, K., TN, K., I, K., C, K., BG, K., C, L., Y, L., H, L., CT, L., RJF, L., MC, M., LW, M., RA, M., BD, M., ME, M., AC, M., T, N., KE, N., ND, P., PA, P., BM, P., S, R., AP, R., SS, R., CM, S., JA, S., KD, T., HK, T., RS, V., S, V., Z, W., J, W., LR, Y., B, Y., Consortium, N. T. F. P. M. (., J, D., JB, M., PL, A., LM, R., AK, M., KM, R., JI, R., GM, P., P, N., Z, L., Z, L., & X, L. (2025). A statistical framework for multi-trait rare variant analysis in large-scale whole-genome sequencing studies.. Nature computational science. https://doi.org/10.1038/s43588-024-00764-8

Source records

pubmed · retrieved 2026-09-25T16:25:40.597Z