CDK8 remodels the tumor microenvironment and promotes resistance to KRASG12D inhibitors and daraxonrasib in PDAC

Kathleen M McAndrews, Krishnan K Mahadevan, Bingrui Li, Anaïs M Comptdaer, Amari M Sockwell, Sami J Morse, Patience J Kelly, Sarah I Patel, Michelle L Kirtley, Barbara A Moreno Diaz, Hengyu Lyu, David H Peng, Sima Khazaei, Aislyn Schalck, Xunian Zhou, Hikaru Sugimoto, Aaron A Bickert, Lakshmi Kavitha Sthanam, Meagan R Taylor, Shreyasee V Kumbhar, Kent A Arian, Yasaman Barekatain, Francesca Paradiso, Paola A Guerrero, Vincent Bernard, Navid Sobhani, Alondra N Camacho-Acevedo, Kiara E Bornes, Phuong Thao Tran, Anirban Maitra, Timothy P Heffernan, Raghu Kalluri

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DOI: 10.1038/s44318-026-00854-5
Published: 2026-07-11
Container: The EMBO Journal
Publisher: Springer Science and Business Media LLC
Open access: unknown

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Cite this work

BibTeX

@article{allodium:10.1038/s44318-026-00854-5,
  title = {CDK8 remodels the tumor microenvironment and promotes resistance to KRASG12D inhibitors and daraxonrasib in PDAC},
  author = {Kathleen M McAndrews and Krishnan K Mahadevan and Bingrui Li and Anaïs M Comptdaer and Amari M Sockwell and Sami J Morse and Patience J Kelly and Sarah I Patel and Michelle L Kirtley and Barbara A Moreno Diaz and Hengyu Lyu and David H Peng and Sima Khazaei and Aislyn Schalck and Xunian Zhou and Hikaru Sugimoto and Aaron A Bickert and Lakshmi Kavitha Sthanam and Meagan R Taylor and Shreyasee V Kumbhar and Kent A Arian and Yasaman Barekatain and Francesca Paradiso and Paola A Guerrero and Vincent Bernard and Navid Sobhani and Alondra N Camacho-Acevedo and Kiara E Bornes and Phuong Thao Tran and Anirban Maitra and Timothy P Heffernan and Raghu Kalluri},
  year = {2026},
  journal = {The EMBO Journal},
  doi = {10.1038/s44318-026-00854-5},
  url = {https://doi.org/10.1038/s44318-026-00854-5}
}

RIS

TY  - JOUR
TI  - CDK8 remodels the tumor microenvironment and promotes resistance to KRASG12D inhibitors and daraxonrasib in PDAC
AU  - Kathleen M McAndrews
AU  - Krishnan K Mahadevan
AU  - Bingrui Li
AU  - Anaïs M Comptdaer
AU  - Amari M Sockwell
AU  - Sami J Morse
AU  - Patience J Kelly
AU  - Sarah I Patel
AU  - Michelle L Kirtley
AU  - Barbara A Moreno Diaz
AU  - Hengyu Lyu
AU  - David H Peng
AU  - Sima Khazaei
AU  - Aislyn Schalck
AU  - Xunian Zhou
AU  - Hikaru Sugimoto
AU  - Aaron A Bickert
AU  - Lakshmi Kavitha Sthanam
AU  - Meagan R Taylor
AU  - Shreyasee V Kumbhar
AU  - Kent A Arian
AU  - Yasaman Barekatain
AU  - Francesca Paradiso
AU  - Paola A Guerrero
AU  - Vincent Bernard
AU  - Navid Sobhani
AU  - Alondra N Camacho-Acevedo
AU  - Kiara E Bornes
AU  - Phuong Thao Tran
AU  - Anirban Maitra
AU  - Timothy P Heffernan
AU  - Raghu Kalluri
PY  - 2026
JO  - The EMBO Journal
DO  - 10.1038/s44318-026-00854-5
UR  - https://doi.org/10.1038/s44318-026-00854-5
ER  -

APA

McAndrews, K. M., Mahadevan, K. K., Li, B., Comptdaer, A. M., Sockwell, A. M., Morse, S. J., Kelly, P. J., Patel, S. I., Kirtley, M. L., Diaz, B. A. M., Lyu, H., Peng, D. H., Khazaei, S., Schalck, A., Zhou, X., Sugimoto, H., Bickert, A. A., Sthanam, L. K., Taylor, M. R., Kumbhar, S. V., Arian, K. A., Barekatain, Y., Paradiso, F., Guerrero, P. A., Bernard, V., Sobhani, N., Camacho-Acevedo, A. N., Bornes, K. E., Tran, P. T., Maitra, A., Heffernan, T. P., & Kalluri, R. (2026). CDK8 remodels the tumor microenvironment and promotes resistance to KRASG12D inhibitors and daraxonrasib in PDAC. The EMBO Journal. https://doi.org/10.1038/s44318-026-00854-5

Source records

crossref · retrieved 2026-09-26T13:17:19.812Z