Validation and analysis of 12,000 AI-driven CAR-T designs in the Bits to Binders competition

Clayton W Kosonocky, Alex M Abel, Aaron L Feller, Amanda E Cifuentes Rieffer, Phillip R Woolley, Jakub Lála, Daryl R Barth, Tynan Gardner, Unknown, Daniel Acosta, Stefano Angioletti-Uberti, Vinayak Annapure, Neil Anthony, Rana A Barghout, Max Beining, Parth Bibekar, Dionessa Biton, Patrick Bryant, Anton Bushuiev, Cianna Calia, Ava Chan, Jie Chen, Akshay Chenna, Nicole Chiang, Vivian Chu, Joseph Clark, Alia Clark-ElSayed, Elliot Cole, Qian Cong, Shreyasi Das, Tanner Dean, Tyler Derr, Alejandro Diaz, Jesse Durham, Moritz Ertelt, Antonio Fonseca, Ora Furman, Tynan Gardner, Jokent Gaza, Nathaniel Greenwood, Rui Guo, Abel Gurung, Vivian Haas, Seyed Alireza Hashemi, Dieter Hoffmann, Sofiia Hoian, Corey Howe, Calvin XiaoYang Hu, Jinling Huang, Nader Ibrahim, Satoshi Ishida, Ansar Ahmad Javed, Aswini Javvadi, Roman Jerala, Daksh Joshi, Even Kiely, Haelyn Kim, Diego Kleiman, Sarah Knapp, Huan Koh, Petr Kouba, Yong Youn Kwon, Duško Lainšček, Jakub Lála, Hakyung Lee, Qiuzhen Li, Max Lingner, Yuxuan Liu, Yunchao Liu, Qianchen Liu, Ajasja Ljubetič, Marko Ludaic, Karl Lundquist, Ashish Makani, Javier Marchena-Hurtado, Freddie Martin, Jens Meiler, Fernando Meireles, David Miller, Nuria Mitjavila, Tjaša Mlakar, Rajarshi Mondal, Saeideh Moradvandi, Rocco Moretti, Sai Jaideep Reddy Mure, Pragati Naikare, Fatemeh Nasiri, Kaveh Nasrollahi, Yisel Martinez Noa, Joseph Openy, Aoi Otani, Vikrant Parmar, Jimin Pei, Alberto Perez, Rajat Punia, Francisco Requena, Dominic Rieger, Aparna Sahu, Elias Sanchez, Rohit Satija, Tadej Satler, Tom Schlegel, Yang Shen, Diwakar Shukla, Rangana De Silva, Benedikt Singer, Arjun Singh, Amardeep Singh, Bhumika Singh, Jinwoong Song, Harish Srinivasan, Hannah Stewart, Zhaoqian Su, Julia Varga, Xin Wang, Dion Whitehead, Matthew Williams, Max Witwer, Rujie Yin, Song Yin, Rongqing Yuan, Nikola Zadorozhny, Dishant Parag Zaveri, Genhui Zheng, Yizhen Zheng, Jian Zhou, Shaowen Zhu, Lin Zhu, Stephen C Ekker, Andrew D Ellington, Wesley A Wierson, Edward M Marcotte

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DOI: 10.1038/s44320-026-00246-1
Published: 2026-10-08
Container: Molecular Systems Biology
Publisher: Springer Science and Business Media LLC
Open access: unknown

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BibTeX

@article{allodium:10.1038/s44320-026-00246-1,
  title = {Validation and analysis of 12,000 AI-driven CAR-T designs in the Bits to Binders competition},
  author = {Clayton W Kosonocky and Alex M Abel and Aaron L Feller and Amanda E Cifuentes Rieffer and Phillip R Woolley and Jakub Lála and Daryl R Barth and Tynan Gardner and Unknown and Daniel Acosta and Stefano Angioletti-Uberti and Vinayak Annapure and Neil Anthony and Rana A Barghout and Max Beining and Parth Bibekar and Dionessa Biton and Patrick Bryant and Anton Bushuiev and Cianna Calia and Ava Chan and Jie Chen and Akshay Chenna and Nicole Chiang and Vivian Chu and Joseph Clark and Alia Clark-ElSayed and Elliot Cole and Qian Cong and Shreyasi Das and Tanner Dean and Tyler Derr and Alejandro Diaz and Jesse Durham and Moritz Ertelt and Antonio Fonseca and Ora Furman and Tynan Gardner and Jokent Gaza and Nathaniel Greenwood and Rui Guo and Abel Gurung and Vivian Haas and Seyed Alireza Hashemi and Dieter Hoffmann and Sofiia Hoian and Corey Howe and Calvin XiaoYang Hu and Jinling Huang and Nader Ibrahim and Satoshi Ishida and Ansar Ahmad Javed and Aswini Javvadi and Roman Jerala and Daksh Joshi and Even Kiely and Haelyn Kim and Diego Kleiman and Sarah Knapp and Huan Koh and Petr Kouba and Yong Youn Kwon and Duško Lainšček and Jakub Lála and Hakyung Lee and Qiuzhen Li and Max Lingner and Yuxuan Liu and Yunchao Liu and Qianchen Liu and Ajasja Ljubetič and Marko Ludaic and Karl Lundquist and Ashish Makani and Javier Marchena-Hurtado and Freddie Martin and Jens Meiler and Fernando Meireles and David Miller and Nuria Mitjavila and Tjaša Mlakar and Rajarshi Mondal and Saeideh Moradvandi and Rocco Moretti and Sai Jaideep Reddy Mure and Pragati Naikare and Fatemeh Nasiri and Kaveh Nasrollahi and Yisel Martinez Noa and Joseph Openy and Aoi Otani and Vikrant Parmar and Jimin Pei and Alberto Perez and Rajat Punia and Francisco Requena and Dominic Rieger and Aparna Sahu and Elias Sanchez and Rohit Satija and Tadej Satler and Tom Schlegel and Yang Shen and Diwakar Shukla and Rangana De Silva and Benedikt Singer and Arjun Singh and Amardeep Singh and Bhumika Singh and Jinwoong Song and Harish Srinivasan and Hannah Stewart and Zhaoqian Su and Julia Varga and Xin Wang and Dion Whitehead and Matthew Williams and Max Witwer and Rujie Yin and Song Yin and Rongqing Yuan and Nikola Zadorozhny and Dishant Parag Zaveri and Genhui Zheng and Yizhen Zheng and Jian Zhou and Shaowen Zhu and Lin Zhu and Stephen C Ekker and Andrew D Ellington and Wesley A Wierson and Edward M Marcotte},
  year = {2026},
  journal = {Molecular Systems Biology},
  doi = {10.1038/s44320-026-00246-1},
  url = {https://doi.org/10.1038/s44320-026-00246-1}
}

RIS

TY  - JOUR
TI  - Validation and analysis of 12,000 AI-driven CAR-T designs in the Bits to Binders competition
AU  - Clayton W Kosonocky
AU  - Alex M Abel
AU  - Aaron L Feller
AU  - Amanda E Cifuentes Rieffer
AU  - Phillip R Woolley
AU  - Jakub Lála
AU  - Daryl R Barth
AU  - Tynan Gardner
AU  - Unknown
AU  - Daniel Acosta
AU  - Stefano Angioletti-Uberti
AU  - Vinayak Annapure
AU  - Neil Anthony
AU  - Rana A Barghout
AU  - Max Beining
AU  - Parth Bibekar
AU  - Dionessa Biton
AU  - Patrick Bryant
AU  - Anton Bushuiev
AU  - Cianna Calia
AU  - Ava Chan
AU  - Jie Chen
AU  - Akshay Chenna
AU  - Nicole Chiang
AU  - Vivian Chu
AU  - Joseph Clark
AU  - Alia Clark-ElSayed
AU  - Elliot Cole
AU  - Qian Cong
AU  - Shreyasi Das
AU  - Tanner Dean
AU  - Tyler Derr
AU  - Alejandro Diaz
AU  - Jesse Durham
AU  - Moritz Ertelt
AU  - Antonio Fonseca
AU  - Ora Furman
AU  - Tynan Gardner
AU  - Jokent Gaza
AU  - Nathaniel Greenwood
AU  - Rui Guo
AU  - Abel Gurung
AU  - Vivian Haas
AU  - Seyed Alireza Hashemi
AU  - Dieter Hoffmann
AU  - Sofiia Hoian
AU  - Corey Howe
AU  - Calvin XiaoYang Hu
AU  - Jinling Huang
AU  - Nader Ibrahim
AU  - Satoshi Ishida
AU  - Ansar Ahmad Javed
AU  - Aswini Javvadi
AU  - Roman Jerala
AU  - Daksh Joshi
AU  - Even Kiely
AU  - Haelyn Kim
AU  - Diego Kleiman
AU  - Sarah Knapp
AU  - Huan Koh
AU  - Petr Kouba
AU  - Yong Youn Kwon
AU  - Duško Lainšček
AU  - Jakub Lála
AU  - Hakyung Lee
AU  - Qiuzhen Li
AU  - Max Lingner
AU  - Yuxuan Liu
AU  - Yunchao Liu
AU  - Qianchen Liu
AU  - Ajasja Ljubetič
AU  - Marko Ludaic
AU  - Karl Lundquist
AU  - Ashish Makani
AU  - Javier Marchena-Hurtado
AU  - Freddie Martin
AU  - Jens Meiler
AU  - Fernando Meireles
AU  - David Miller
AU  - Nuria Mitjavila
AU  - Tjaša Mlakar
AU  - Rajarshi Mondal
AU  - Saeideh Moradvandi
AU  - Rocco Moretti
AU  - Sai Jaideep Reddy Mure
AU  - Pragati Naikare
AU  - Fatemeh Nasiri
AU  - Kaveh Nasrollahi
AU  - Yisel Martinez Noa
AU  - Joseph Openy
AU  - Aoi Otani
AU  - Vikrant Parmar
AU  - Jimin Pei
AU  - Alberto Perez
AU  - Rajat Punia
AU  - Francisco Requena
AU  - Dominic Rieger
AU  - Aparna Sahu
AU  - Elias Sanchez
AU  - Rohit Satija
AU  - Tadej Satler
AU  - Tom Schlegel
AU  - Yang Shen
AU  - Diwakar Shukla
AU  - Rangana De Silva
AU  - Benedikt Singer
AU  - Arjun Singh
AU  - Amardeep Singh
AU  - Bhumika Singh
AU  - Jinwoong Song
AU  - Harish Srinivasan
AU  - Hannah Stewart
AU  - Zhaoqian Su
AU  - Julia Varga
AU  - Xin Wang
AU  - Dion Whitehead
AU  - Matthew Williams
AU  - Max Witwer
AU  - Rujie Yin
AU  - Song Yin
AU  - Rongqing Yuan
AU  - Nikola Zadorozhny
AU  - Dishant Parag Zaveri
AU  - Genhui Zheng
AU  - Yizhen Zheng
AU  - Jian Zhou
AU  - Shaowen Zhu
AU  - Lin Zhu
AU  - Stephen C Ekker
AU  - Andrew D Ellington
AU  - Wesley A Wierson
AU  - Edward M Marcotte
PY  - 2026
JO  - Molecular Systems Biology
DO  - 10.1038/s44320-026-00246-1
UR  - https://doi.org/10.1038/s44320-026-00246-1
ER  -

APA

Kosonocky, C. W., Abel, A. M., Feller, A. L., Rieffer, A. E. C., Woolley, P. R., Lála, J., Barth, D. R., Gardner, T., Unknown, Acosta, D., Angioletti-Uberti, S., Annapure, V., Anthony, N., Barghout, R. A., Beining, M., Bibekar, P., Biton, D., Bryant, P., Bushuiev, A., Calia, C., Chan, A., Chen, J., Chenna, A., Chiang, N., Chu, V., Clark, J., Clark-ElSayed, A., Cole, E., Cong, Q., Das, S., Dean, T., Derr, T., Diaz, A., Durham, J., Ertelt, M., Fonseca, A., Furman, O., Gardner, T., Gaza, J., Greenwood, N., Guo, R., Gurung, A., Haas, V., Hashemi, S. A., Hoffmann, D., Hoian, S., Howe, C., Hu, C. X., Huang, J., Ibrahim, N., Ishida, S., Javed, A. A., Javvadi, A., Jerala, R., Joshi, D., Kiely, E., Kim, H., Kleiman, D., Knapp, S., Koh, H., Kouba, P., Kwon, Y. Y., Lainšček, D., Lála, J., Lee, H., Li, Q., Lingner, M., Liu, Y., Liu, Y., Liu, Q., Ljubetič, A., Ludaic, M., Lundquist, K., Makani, A., Marchena-Hurtado, J., Martin, F., Meiler, J., Meireles, F., Miller, D., Mitjavila, N., Mlakar, T., Mondal, R., Moradvandi, S., Moretti, R., Mure, S. J. R., Naikare, P., Nasiri, F., Nasrollahi, K., Noa, Y. M., Openy, J., Otani, A., Parmar, V., Pei, J., Perez, A., Punia, R., Requena, F., Rieger, D., Sahu, A., Sanchez, E., Satija, R., Satler, T., Schlegel, T., Shen, Y., Shukla, D., Silva, R. D., Singer, B., Singh, A., Singh, A., Singh, B., Song, J., Srinivasan, H., Stewart, H., Su, Z., Varga, J., Wang, X., Whitehead, D., Williams, M., Witwer, M., Yin, R., Yin, S., Yuan, R., Zadorozhny, N., Zaveri, D. P., Zheng, G., Zheng, Y., Zhou, J., Zhu, S., Zhu, L., Ekker, S. C., Ellington, A. D., Wierson, W. A., & Marcotte, E. M. (2026). Validation and analysis of 12,000 AI-driven CAR-T designs in the Bits to Binders competition. Molecular Systems Biology. https://doi.org/10.1038/s44320-026-00246-1

Source records

crossref · retrieved 2026-11-08T09:05:41.728Z