mRNA delivery of a class 1/4 SARS-CoV-2 neutralizing antibody protects against diverse sarbecoviruses in a lethal mouse challenge model

Ashwin N. Skelly, Chengcheng Fan, Jennifer R. Keeffe, Arya B. Ökten, Edem Gavor, Maddy L. Newby, Joel D. Allen, Edward F. Kreider, Wenge Ding, Rebecca A. Osbaldeston, Younghoon Park, Andrew J. Connell, Melinda G. Lituchy, Frederic Bibollet-Ruche, Katelyn M. Radford, Anthony P. West, Mario A. Peña-Hernández, Kendra Cruickshank, Weimin Liu, Yingying Li, Amie Albertus, Brieyanna McWilliams, Ronnie M. Russell, Kylie M. Konrath, Jonathan L. Torres, Meng Yuan, Hongmei Gao, David C. Montefiori, Michael S. Saag, Paul A. Goepfert, Daniel W. Kulp, Andrew B. Ward, Ian A. Wilson, George M. Shaw, Raiees Andrabi, Max Crispin, Drew Weissman, Craig B. Wilen, Pamela J. Bjorkman, Beatrice H. Hahn

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DOI: 10.1073/pnas.2536870123
Published: 2026-06-08
Container: Proceedings of the National Academy of Sciences
Publisher: National Academy of Sciences
Open access: unknown

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Cite this work

BibTeX

@article{allodium:10.1073/pnas.2536870123,
  title = {mRNA delivery of a class 1/4 SARS-CoV-2 neutralizing antibody protects against diverse sarbecoviruses in a lethal mouse challenge model},
  author = {Ashwin N. Skelly and Chengcheng Fan and Jennifer R. Keeffe and Arya B. Ökten and Edem Gavor and Maddy L. Newby and Joel D. Allen and Edward F. Kreider and Wenge Ding and Rebecca A. Osbaldeston and Younghoon Park and Andrew J. Connell and Melinda G. Lituchy and Frederic Bibollet-Ruche and Katelyn M. Radford and Anthony P. West and Mario A. Peña-Hernández and Kendra Cruickshank and Weimin Liu and Yingying Li and Amie Albertus and Brieyanna McWilliams and Ronnie M. Russell and Kylie M. Konrath and Jonathan L. Torres and Meng Yuan and Hongmei Gao and David C. Montefiori and Michael S. Saag and Paul A. Goepfert and Daniel W. Kulp and Andrew B. Ward and Ian A. Wilson and George M. Shaw and Raiees Andrabi and Max Crispin and Drew Weissman and Craig B. Wilen and Pamela J. Bjorkman and Beatrice H. Hahn},
  year = {2026},
  journal = {Proceedings of the National Academy of Sciences},
  doi = {10.1073/pnas.2536870123},
  url = {https://doi.org/10.1073/pnas.2536870123}
}

RIS

TY  - JOUR
TI  - mRNA delivery of a class 1/4 SARS-CoV-2 neutralizing antibody protects against diverse sarbecoviruses in a lethal mouse challenge model
AU  - Ashwin N. Skelly
AU  - Chengcheng Fan
AU  - Jennifer R. Keeffe
AU  - Arya B. Ökten
AU  - Edem Gavor
AU  - Maddy L. Newby
AU  - Joel D. Allen
AU  - Edward F. Kreider
AU  - Wenge Ding
AU  - Rebecca A. Osbaldeston
AU  - Younghoon Park
AU  - Andrew J. Connell
AU  - Melinda G. Lituchy
AU  - Frederic Bibollet-Ruche
AU  - Katelyn M. Radford
AU  - Anthony P. West
AU  - Mario A. Peña-Hernández
AU  - Kendra Cruickshank
AU  - Weimin Liu
AU  - Yingying Li
AU  - Amie Albertus
AU  - Brieyanna McWilliams
AU  - Ronnie M. Russell
AU  - Kylie M. Konrath
AU  - Jonathan L. Torres
AU  - Meng Yuan
AU  - Hongmei Gao
AU  - David C. Montefiori
AU  - Michael S. Saag
AU  - Paul A. Goepfert
AU  - Daniel W. Kulp
AU  - Andrew B. Ward
AU  - Ian A. Wilson
AU  - George M. Shaw
AU  - Raiees Andrabi
AU  - Max Crispin
AU  - Drew Weissman
AU  - Craig B. Wilen
AU  - Pamela J. Bjorkman
AU  - Beatrice H. Hahn
PY  - 2026
JO  - Proceedings of the National Academy of Sciences
DO  - 10.1073/pnas.2536870123
UR  - https://doi.org/10.1073/pnas.2536870123
ER  -

APA

Skelly, A. N., Fan, C., Keeffe, J. R., Ökten, A. B., Gavor, E., Newby, M. L., Allen, J. D., Kreider, E. F., Ding, W., Osbaldeston, R. A., Park, Y., Connell, A. J., Lituchy, M. G., Bibollet-Ruche, F., Radford, K. M., West, A. P., Peña-Hernández, M. A., Cruickshank, K., Liu, W., Li, Y., Albertus, A., McWilliams, B., Russell, R. M., Konrath, K. M., Torres, J. L., Yuan, M., Gao, H., Montefiori, D. C., Saag, M. S., Goepfert, P. A., Kulp, D. W., Ward, A. B., Wilson, I. A., Shaw, G. M., Andrabi, R., Crispin, M., Weissman, D., Wilen, C. B., Bjorkman, P. J., & Hahn, B. H. (2026). mRNA delivery of a class 1/4 SARS-CoV-2 neutralizing antibody protects against diverse sarbecoviruses in a lethal mouse challenge model. Proceedings of the National Academy of Sciences. https://doi.org/10.1073/pnas.2536870123

Source records

crossref · retrieved 2026-09-27T04:50:34.696Z