Structural rewiring of IL-7R dimerization by an oncogenic transmembrane mutation can be reversed by rational design

Qian Wang, Min Chen, Asma Lasram, Saana Vihuri, Angela Z. Chou, Weixin Bian, Zhiming Dai, Outi Haapanen, Giray Enkavi, Christoph Pollmann, Ilpo Vattulainen, Tiantian Cai, Jacob Piehler, James J. Chou

Open source

DOI
10.1073/pnas.2601748123
Published
2026-04-28
Container
Proceedings of the National Academy of Sciences
Publisher
National Academy of Sciences
Open access
unknown

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BibTeX

@article{allodium:10.1073/pnas.2601748123,
  title = {Structural rewiring of IL-7R dimerization by an oncogenic transmembrane mutation can be reversed by rational design},
  author = {Qian Wang and Min Chen and Asma Lasram and Saana Vihuri and Angela Z. Chou and Weixin Bian and Zhiming Dai and Outi Haapanen and Giray Enkavi and Christoph Pollmann and Ilpo Vattulainen and Tiantian Cai and Jacob Piehler and James J. Chou},
  year = {2026},
  journal = {Proceedings of the National Academy of Sciences},
  doi = {10.1073/pnas.2601748123},
  url = {https://doi.org/10.1073/pnas.2601748123}
}

RIS

TY  - JOUR
TI  - Structural rewiring of IL-7R dimerization by an oncogenic transmembrane mutation can be reversed by rational design
AU  - Qian Wang
AU  - Min Chen
AU  - Asma Lasram
AU  - Saana Vihuri
AU  - Angela Z. Chou
AU  - Weixin Bian
AU  - Zhiming Dai
AU  - Outi Haapanen
AU  - Giray Enkavi
AU  - Christoph Pollmann
AU  - Ilpo Vattulainen
AU  - Tiantian Cai
AU  - Jacob Piehler
AU  - James J. Chou
PY  - 2026
JO  - Proceedings of the National Academy of Sciences
DO  - 10.1073/pnas.2601748123
UR  - https://doi.org/10.1073/pnas.2601748123
ER  - 

APA

Wang, Q., Chen, M., Lasram, A., Vihuri, S., Chou, A. Z., Bian, W., Dai, Z., Haapanen, O., Enkavi, G., Pollmann, C., Vattulainen, I., Cai, T., Piehler, J., & Chou, J. J. (2026). Structural rewiring of IL-7R dimerization by an oncogenic transmembrane mutation can be reversed by rational design. Proceedings of the National Academy of Sciences. https://doi.org/10.1073/pnas.2601748123

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