Mitochondrial NADP(H)–dependent de novo dTMP biosynthesis counteracts the cytotoxicity of PARP inhibitors

Qing Li, Tong Shu, Chen Liu, Min Zheng, Yuanpei Li, Lei Zhang, Gao Fan, Wenbin Lu, Huiwen Zhang, Pingping Liu, Xiaoniu He, Hong Zheng, Wen Liu, Jing Ye, Zhenyu Yin, Xianming Deng, Chensong Zhang, Canhua Huang, Han You

Open source

DOI
10.1073/pnas.2607452123
Published
2026-09-24
Container
Proceedings of the National Academy of Sciences
Publisher
National Academy of Sciences
Open access
unknown

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Cite this work

BibTeX

@article{allodium:10.1073/pnas.2607452123,
  title = {Mitochondrial NADP(H)–dependent de novo dTMP biosynthesis counteracts the cytotoxicity of PARP inhibitors},
  author = {Qing Li and Tong Shu and Chen Liu and Min Zheng and Yuanpei Li and Lei Zhang and Gao Fan and Wenbin Lu and Huiwen Zhang and Pingping Liu and Xiaoniu He and Hong Zheng and Wen Liu and Jing Ye and Zhenyu Yin and Xianming Deng and Chensong Zhang and Canhua Huang and Han You},
  year = {2026},
  journal = {Proceedings of the National Academy of Sciences},
  doi = {10.1073/pnas.2607452123},
  url = {https://doi.org/10.1073/pnas.2607452123}
}

RIS

TY  - JOUR
TI  - Mitochondrial NADP(H)–dependent de novo dTMP biosynthesis counteracts the cytotoxicity of PARP inhibitors
AU  - Qing Li
AU  - Tong Shu
AU  - Chen Liu
AU  - Min Zheng
AU  - Yuanpei Li
AU  - Lei Zhang
AU  - Gao Fan
AU  - Wenbin Lu
AU  - Huiwen Zhang
AU  - Pingping Liu
AU  - Xiaoniu He
AU  - Hong Zheng
AU  - Wen Liu
AU  - Jing Ye
AU  - Zhenyu Yin
AU  - Xianming Deng
AU  - Chensong Zhang
AU  - Canhua Huang
AU  - Han You
PY  - 2026
JO  - Proceedings of the National Academy of Sciences
DO  - 10.1073/pnas.2607452123
UR  - https://doi.org/10.1073/pnas.2607452123
ER  - 

APA

Li, Q., Shu, T., Liu, C., Zheng, M., Li, Y., Zhang, L., Fan, G., Lu, W., Zhang, H., Liu, P., He, X., Zheng, H., Liu, W., Ye, J., Yin, Z., Deng, X., Zhang, C., Huang, C., & You, H. (2026). Mitochondrial NADP(H)–dependent de novo dTMP biosynthesis counteracts the cytotoxicity of PARP inhibitors. Proceedings of the National Academy of Sciences. https://doi.org/10.1073/pnas.2607452123

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