PTPN23-dependent activation of PI3KC2α is a therapeutic vulnerability of BRAF-mutant cancers.

He Y, Li W, Zhang M, Wang H, Lin P, Yu Y, Huang B, Hao M, He J, Kong W, Luo D, Xu T, Wang J, Huang Y, Zhao Q, Liu Y, Zhang J, Nian Y, Zhang L, Zhu B, Yin C

Open source

DOI: 10.1084/jem.20241147
Published: 2025 Mar 3
Container: The Journal of experimental medicine
Publisher: Not recorded
Open access: yes

Credibility signals

limited evidence Score 45/100 under policy 1.0.0. This is a metadata assessment, not a judgment of the paper's conclusions.

Show all credibility signals

cautionDOI registered: No matching Crossref record was present in this response. Source: Crossref; license: CC0 metadata
cautionDOI resolves: No matching Crossref record was present in this response. Source: Crossref; license: CC0 metadata
not scoredDirectory of Open Access Journals: No matching DOAJ record was present in this response. No allow-list match; this is not evidence of low credibility. Source: DOAJ; license: CC0
not scoredMEDLINE indexed: Not checked or no result supplied; no credibility inference made. Source: No authority result supplied; license: Unknown
not scoredOpenAlex core source: Not checked or no result supplied; no credibility inference made. Source: No authority result supplied; license: Unknown
not scoredKnown publisher allow-list: Not checked or no result supplied; no credibility inference made. Source: No authority result supplied; license: Unknown
not scoredROR affiliation: Not checked or no result supplied; no credibility inference made. Source: No authority result supplied; license: Unknown
not scoredRetraction Watch retraction: No retraction notice matched this DOI in the deployed snapshot. No matching event found; coverage may be incomplete. Source: Retraction Watch; license: CC BY 4.0
not scoredRetraction Watch expression of concern: No expression of concern notice matched this DOI in the deployed snapshot. No matching event found; coverage may be incomplete. Source: Retraction Watch; license: CC BY 4.0
not scoredRetraction Watch correction: No correction notice matched this DOI in the deployed snapshot. No matching event found; coverage may be incomplete. Source: Retraction Watch; license: CC BY 4.0
not scoredRetraction Watch reinstatement: No reinstatement notice matched this DOI in the deployed snapshot. No matching event found; coverage may be incomplete. Source: Retraction Watch; license: CC BY 4.0
supportingOpen access status: Normalized open-access status: open. Source: Normalized work metadata; license: Caller-provided; provenance license not supplied to scorer
not scoredPublication license: Not checked or no result supplied; no credibility inference made. Source: No authority result supplied; license: Unknown
not scoredPublication version: A publication version was supplied but is not scored. Source: Normalized work metadata; license: Caller-provided; provenance license not supplied to scorer
cautionMetadata completeness: 5 of 6 scored descriptive metadata groups are present; missing fields increase uncertainty. Source: Normalized work metadata; license: Caller-provided; provenance license not supplied to scorer

Cite this work

BibTeX

@article{allodium:10.1084/jem.20241147,
  title = {PTPN23-dependent activation of PI3KC2α is a therapeutic vulnerability of BRAF-mutant cancers.},
  author = {He Y and Li W and Zhang M and Wang H and Lin P and Yu Y and Huang B and Hao M and He J and Kong W and Luo D and Xu T and Wang J and Huang Y and Zhao Q and Liu Y and Zhang J and Nian Y and Zhang L and Zhu B and Yin C},
  year = {2025},
  journal = {The Journal of experimental medicine},
  doi = {10.1084/jem.20241147},
  url = {https://doi.org/10.1084/jem.20241147}
}

RIS

TY  - JOUR
TI  - PTPN23-dependent activation of PI3KC2α is a therapeutic vulnerability of BRAF-mutant cancers.
AU  - He Y
AU  - Li W
AU  - Zhang M
AU  - Wang H
AU  - Lin P
AU  - Yu Y
AU  - Huang B
AU  - Hao M
AU  - He J
AU  - Kong W
AU  - Luo D
AU  - Xu T
AU  - Wang J
AU  - Huang Y
AU  - Zhao Q
AU  - Liu Y
AU  - Zhang J
AU  - Nian Y
AU  - Zhang L
AU  - Zhu B
AU  - Yin C
PY  - 2025
JO  - The Journal of experimental medicine
DO  - 10.1084/jem.20241147
UR  - https://doi.org/10.1084/jem.20241147
ER  -

APA

Y, H., W, L., M, Z., H, W., P, L., Y, Y., B, H., M, H., J, H., W, K., D, L., T, X., J, W., Y, H., Q, Z., Y, L., J, Z., Y, N., L, Z., B, Z., & C, Y. (2025). PTPN23-dependent activation of PI3KC2α is a therapeutic vulnerability of BRAF-mutant cancers.. The Journal of experimental medicine. https://doi.org/10.1084/jem.20241147

Source records

pubmed · retrieved 2026-09-25T19:47:17.090Z