Treatment escalation after clinically silent MRI lesions in relapsing-remitting multiple sclerosis

Cyrus Daruwalla, Courtney Kremler, Francesco Patti, Serkan Ozakbas, Cavit Boz, Jeannette Lechner-Scott, Andrea Surcinelli, Matteo Foschi, Samia J Khoury, Helmut Butzkueven, Anneke van der Walt, Zuzana Rous, Mario Habek, Jose E Meca-Lallana, Gabriel Valero Lopez, Raed Alroughani, Yolanda Blanco, Guy Laureys, Olga Skibina, Katherine Buzzard, Orla Gray, Pamela McCombe, Davide Maimone, Pierre Duquette, Marc Girard, Alexandre Prat, Jose Luis Sanchez-Menoyo, Vincent van Pesch, Aysun Soysal, Maria Pia Amato, Francois Grand'Maison, Judith Wilton, Bart Van Wijmeersch, Oliver Gerlach, Alessandra Lugaresi, Valentina Tomassini, Giovanna De Luca, Bruce Taylor, Yi Chao Foong, Nevin John, Simón Cárdenas-Robledo, Suzanne Hodgkinson, Richard Macdonell, Barbara Willekens, Justin Garber, Emanuele D'Amico, Murat Terzi, Jana Houskova, Emmanuelle Lapointe, Abdullah Al-Asmi, Michael Barnett, Ivana Stetkarova, Riadh Gouider, Saloua Mrabet, Tunde Csepany, Chris McGuigan, Katrin Gross-Paju, Jens Kuhle, Tamara Castillo-Triviño, Simon Kerrigan, Aviva M Tolkovsky, Mark Wardle, Nick G Cunniffe, Izanne Roos, Paul Madley-Dowd, Alasdair Coles, Tomas Kalincik, Jonathan A C Sterne, J William L Brown, Unknown, Mark Marriott, Trevor Kilpatrick, John King, Katherine Buzzard, Ai-Lan Nguyen, Chris Dwyer, Vivien Li, Prashanth Ramachandran, Melissa Chu, Lisa Taylor, Katherine Fazzolari, Hasini Fernando, Margaret Bolger, Jersey Higgins, Clara Chisari, Lo Fermo Salvatore, Catherine Larochelle, Raymond Hupperts, Juan Camilo Carrillo, Javier Olascoaga, Jana Libertinova, Marek Paterka, Marta Vachova, Tomas Kalincik, Bassem Yamout, Pierre Grammond, Sara Eichau, Guillermo Izquierdo, Daniele Spitaleri, Jiwon Oh, Pavel Hradilek, Michal Dufek, Silvia Messina, Elisabetta Cartechini, Jennifer Massey, Mark Slee, Joana Guimarães, Maria Edite Rio, Angel Perez sempere, Gregor Brecl Jakob, Danny Decoo, Jose Antonio Cabrera-Gomez, Todd A Hardy, Marija Cauchi, Melissa Cambron, Fraser Moore, Jose Andres Dominguez, Nikolaos Grigoriadis, Noriko Isobe, Jan Mares, Chiyoko Nohara, Masayuki Mizuno, Fumitaka Shimizu, Guntis Karelis, Ayse Altintas, Abdorreza Naser Moghadasi, Talal Al-Harbi, Cristina Ramo-Tello, Imre Piroska, Edgardo Cristiano, Cameron Shaw, Neil Shuey, Mike Boggild, Julie Prevost, Seyed Mohammad Baghbanian, Kenzo Sakurai, Eli Skromne, Deborah Mason, Jabir Alkhaboori, Victor Babes Timisoara, Mihaela Simu, Recai Turkoglu, John Parratt, Nevin Shalaby, Magdolna Simo, Krisztina Kovacs, Attila Sas, Andrea Mike, Yuri Nakamura, Beatriz Romero Ferrando, Canan Yucesan, Oksana Kopchak

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DOI
10.1093/brain/awag252
Published
2026-07-24
Container
Brain
Publisher
Oxford University Press (OUP)
Open access
unknown

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BibTeX

@article{allodium:10.1093/brain/awag252,
  title = {Treatment escalation after clinically silent MRI lesions in relapsing-remitting multiple sclerosis},
  author = {Cyrus Daruwalla and Courtney Kremler and Francesco Patti and Serkan Ozakbas and Cavit Boz and Jeannette Lechner-Scott and Andrea Surcinelli and Matteo Foschi and Samia J Khoury and Helmut Butzkueven and Anneke van der Walt and Zuzana Rous and Mario Habek and Jose E Meca-Lallana and Gabriel Valero Lopez and Raed Alroughani and Yolanda Blanco and Guy Laureys and Olga Skibina and Katherine Buzzard and Orla Gray and Pamela McCombe and Davide Maimone and Pierre Duquette and Marc Girard and Alexandre Prat and Jose Luis Sanchez-Menoyo and Vincent van Pesch and Aysun Soysal and Maria Pia Amato and Francois Grand'Maison and Judith Wilton and Bart Van Wijmeersch and Oliver Gerlach and Alessandra Lugaresi and Valentina Tomassini and Giovanna De Luca and Bruce Taylor and Yi Chao Foong and Nevin John and Simón Cárdenas-Robledo and Suzanne Hodgkinson and Richard Macdonell and Barbara Willekens and Justin Garber and Emanuele D'Amico and Murat Terzi and Jana Houskova and Emmanuelle Lapointe and Abdullah Al-Asmi and Michael Barnett and Ivana Stetkarova and Riadh Gouider and Saloua Mrabet and Tunde Csepany and Chris McGuigan and Katrin Gross-Paju and Jens Kuhle and Tamara Castillo-Triviño and Simon Kerrigan and Aviva M Tolkovsky and Mark Wardle and Nick G Cunniffe and Izanne Roos and Paul Madley-Dowd and Alasdair Coles and Tomas Kalincik and Jonathan A C Sterne and J William L Brown and Unknown and Mark Marriott and Trevor Kilpatrick and John King and Katherine Buzzard and Ai-Lan Nguyen and Chris Dwyer and Vivien Li and Prashanth Ramachandran and Melissa Chu and Lisa Taylor and Katherine Fazzolari and Hasini Fernando and Margaret Bolger and Jersey Higgins and Clara Chisari and Lo Fermo Salvatore and Catherine Larochelle and Raymond Hupperts and Juan Camilo Carrillo and Javier Olascoaga and Jana Libertinova and Marek Paterka and Marta Vachova and Tomas Kalincik and Bassem Yamout and Pierre Grammond and Sara Eichau and Guillermo Izquierdo and Daniele Spitaleri and Jiwon Oh and Pavel Hradilek and Michal Dufek and Silvia Messina and Elisabetta Cartechini and Jennifer Massey and Mark Slee and Joana Guimarães and Maria Edite Rio and Angel Perez sempere and Gregor Brecl Jakob and Danny Decoo and Jose Antonio Cabrera-Gomez and Todd A Hardy and Marija Cauchi and Melissa Cambron and Fraser Moore and Jose Andres Dominguez and Nikolaos Grigoriadis and Noriko Isobe and Jan Mares and Chiyoko Nohara and Masayuki Mizuno and Fumitaka Shimizu and Guntis Karelis and Ayse Altintas and Abdorreza Naser Moghadasi and Talal Al-Harbi and Cristina Ramo-Tello and Imre Piroska and Edgardo Cristiano and Cameron Shaw and Neil Shuey and Mike Boggild and Julie Prevost and Seyed Mohammad Baghbanian and Kenzo Sakurai and Eli Skromne and Deborah Mason and Jabir Alkhaboori and Victor Babes Timisoara and Mihaela Simu and Recai Turkoglu and John Parratt and Nevin Shalaby and Magdolna Simo and Krisztina Kovacs and Attila Sas and Andrea Mike and Yuri Nakamura and Beatriz Romero Ferrando and Canan Yucesan and Oksana Kopchak},
  year = {2026},
  journal = {Brain},
  doi = {10.1093/brain/awag252},
  url = {https://doi.org/10.1093/brain/awag252}
}

RIS

TY  - JOUR
TI  - Treatment escalation after clinically silent MRI lesions in relapsing-remitting multiple sclerosis
AU  - Cyrus Daruwalla
AU  - Courtney Kremler
AU  - Francesco Patti
AU  - Serkan Ozakbas
AU  - Cavit Boz
AU  - Jeannette Lechner-Scott
AU  - Andrea Surcinelli
AU  - Matteo Foschi
AU  - Samia J Khoury
AU  - Helmut Butzkueven
AU  - Anneke van der Walt
AU  - Zuzana Rous
AU  - Mario Habek
AU  - Jose E Meca-Lallana
AU  - Gabriel Valero Lopez
AU  - Raed Alroughani
AU  - Yolanda Blanco
AU  - Guy Laureys
AU  - Olga Skibina
AU  - Katherine Buzzard
AU  - Orla Gray
AU  - Pamela McCombe
AU  - Davide Maimone
AU  - Pierre Duquette
AU  - Marc Girard
AU  - Alexandre Prat
AU  - Jose Luis Sanchez-Menoyo
AU  - Vincent van Pesch
AU  - Aysun Soysal
AU  - Maria Pia Amato
AU  - Francois Grand'Maison
AU  - Judith Wilton
AU  - Bart Van Wijmeersch
AU  - Oliver Gerlach
AU  - Alessandra Lugaresi
AU  - Valentina Tomassini
AU  - Giovanna De Luca
AU  - Bruce Taylor
AU  - Yi Chao Foong
AU  - Nevin John
AU  - Simón Cárdenas-Robledo
AU  - Suzanne Hodgkinson
AU  - Richard Macdonell
AU  - Barbara Willekens
AU  - Justin Garber
AU  - Emanuele D'Amico
AU  - Murat Terzi
AU  - Jana Houskova
AU  - Emmanuelle Lapointe
AU  - Abdullah Al-Asmi
AU  - Michael Barnett
AU  - Ivana Stetkarova
AU  - Riadh Gouider
AU  - Saloua Mrabet
AU  - Tunde Csepany
AU  - Chris McGuigan
AU  - Katrin Gross-Paju
AU  - Jens Kuhle
AU  - Tamara Castillo-Triviño
AU  - Simon Kerrigan
AU  - Aviva M Tolkovsky
AU  - Mark Wardle
AU  - Nick G Cunniffe
AU  - Izanne Roos
AU  - Paul Madley-Dowd
AU  - Alasdair Coles
AU  - Tomas Kalincik
AU  - Jonathan A C Sterne
AU  - J William L Brown
AU  - Unknown
AU  - Mark Marriott
AU  - Trevor Kilpatrick
AU  - John King
AU  - Katherine Buzzard
AU  - Ai-Lan Nguyen
AU  - Chris Dwyer
AU  - Vivien Li
AU  - Prashanth Ramachandran
AU  - Melissa Chu
AU  - Lisa Taylor
AU  - Katherine Fazzolari
AU  - Hasini Fernando
AU  - Margaret Bolger
AU  - Jersey Higgins
AU  - Clara Chisari
AU  - Lo Fermo Salvatore
AU  - Catherine Larochelle
AU  - Raymond Hupperts
AU  - Juan Camilo Carrillo
AU  - Javier Olascoaga
AU  - Jana Libertinova
AU  - Marek Paterka
AU  - Marta Vachova
AU  - Tomas Kalincik
AU  - Bassem Yamout
AU  - Pierre Grammond
AU  - Sara Eichau
AU  - Guillermo Izquierdo
AU  - Daniele Spitaleri
AU  - Jiwon Oh
AU  - Pavel Hradilek
AU  - Michal Dufek
AU  - Silvia Messina
AU  - Elisabetta Cartechini
AU  - Jennifer Massey
AU  - Mark Slee
AU  - Joana Guimarães
AU  - Maria Edite Rio
AU  - Angel Perez sempere
AU  - Gregor Brecl Jakob
AU  - Danny Decoo
AU  - Jose Antonio Cabrera-Gomez
AU  - Todd A Hardy
AU  - Marija Cauchi
AU  - Melissa Cambron
AU  - Fraser Moore
AU  - Jose Andres Dominguez
AU  - Nikolaos Grigoriadis
AU  - Noriko Isobe
AU  - Jan Mares
AU  - Chiyoko Nohara
AU  - Masayuki Mizuno
AU  - Fumitaka Shimizu
AU  - Guntis Karelis
AU  - Ayse Altintas
AU  - Abdorreza Naser Moghadasi
AU  - Talal Al-Harbi
AU  - Cristina Ramo-Tello
AU  - Imre Piroska
AU  - Edgardo Cristiano
AU  - Cameron Shaw
AU  - Neil Shuey
AU  - Mike Boggild
AU  - Julie Prevost
AU  - Seyed Mohammad Baghbanian
AU  - Kenzo Sakurai
AU  - Eli Skromne
AU  - Deborah Mason
AU  - Jabir Alkhaboori
AU  - Victor Babes Timisoara
AU  - Mihaela Simu
AU  - Recai Turkoglu
AU  - John Parratt
AU  - Nevin Shalaby
AU  - Magdolna Simo
AU  - Krisztina Kovacs
AU  - Attila Sas
AU  - Andrea Mike
AU  - Yuri Nakamura
AU  - Beatriz Romero Ferrando
AU  - Canan Yucesan
AU  - Oksana Kopchak
PY  - 2026
JO  - Brain
DO  - 10.1093/brain/awag252
UR  - https://doi.org/10.1093/brain/awag252
ER  -

APA

Daruwalla, C., Kremler, C., Patti, F., Ozakbas, S., Boz, C., Lechner-Scott, J., Surcinelli, A., Foschi, M., Khoury, S. J., Butzkueven, H., Walt, A. V. D., Rous, Z., Habek, M., Meca-Lallana, J. E., Lopez, G. V., Alroughani, R., Blanco, Y., Laureys, G., Skibina, O., Buzzard, K., Gray, O., McCombe, P., Maimone, D., Duquette, P., Girard, M., Prat, A., Sanchez-Menoyo, J. L., Pesch, V. V., Soysal, A., Amato, M. P., Grand'Maison, F., Wilton, J., Wijmeersch, B. V., Gerlach, O., Lugaresi, A., Tomassini, V., Luca, G. D., Taylor, B., Foong, Y. C., John, N., Cárdenas-Robledo, S., Hodgkinson, S., Macdonell, R., Willekens, B., Garber, J., D'Amico, E., Terzi, M., Houskova, J., Lapointe, E., Al-Asmi, A., Barnett, M., Stetkarova, I., Gouider, R., Mrabet, S., Csepany, T., McGuigan, C., Gross-Paju, K., Kuhle, J., Castillo-Triviño, T., Kerrigan, S., Tolkovsky, A. M., Wardle, M., Cunniffe, N. G., Roos, I., Madley-Dowd, P., Coles, A., Kalincik, T., Sterne, J. A. C., Brown, J. W. L., Unknown, Marriott, M., Kilpatrick, T., King, J., Buzzard, K., Nguyen, A., Dwyer, C., Li, V., Ramachandran, P., Chu, M., Taylor, L., Fazzolari, K., Fernando, H., Bolger, M., Higgins, J., Chisari, C., Salvatore, L. F., Larochelle, C., Hupperts, R., Carrillo, J. C., Olascoaga, J., Libertinova, J., Paterka, M., Vachova, M., Kalincik, T., Yamout, B., Grammond, P., Eichau, S., Izquierdo, G., Spitaleri, D., Oh, J., Hradilek, P., Dufek, M., Messina, S., Cartechini, E., Massey, J., Slee, M., Guimarães, J., Rio, M. E., sempere, A. P., Jakob, G. B., Decoo, D., Cabrera-Gomez, J. A., Hardy, T. A., Cauchi, M., Cambron, M., Moore, F., Dominguez, J. A., Grigoriadis, N., Isobe, N., Mares, J., Nohara, C., Mizuno, M., Shimizu, F., Karelis, G., Altintas, A., Moghadasi, A. N., Al-Harbi, T., Ramo-Tello, C., Piroska, I., Cristiano, E., Shaw, C., Shuey, N., Boggild, M., Prevost, J., Baghbanian, S. M., Sakurai, K., Skromne, E., Mason, D., Alkhaboori, J., Timisoara, V. B., Simu, M., Turkoglu, R., Parratt, J., Shalaby, N., Simo, M., Kovacs, K., Sas, A., Mike, A., Nakamura, Y., Ferrando, B. R., Yucesan, C., & Kopchak, O. (2026). Treatment escalation after clinically silent MRI lesions in relapsing-remitting multiple sclerosis. Brain. https://doi.org/10.1093/brain/awag252

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