SARS-CoV-2 RNA and Nucleocapsid Antigen Are Blood Biomarkers Associated With Severe Disease Outcomes That Improve in Response to Remdesivir

Kanal Singh, Kevin Rubenstein, Viviane Callier, Katy Shaw-Saliba, Adam Rupert, Robin Dewar, Sylvain Laverdure, Helene Highbarger, Perrine Lallemand, Meei-Li Huang, Keith R Jerome, Reigran Sampoleo, Margaret G Mills, Alexander L Greninger, Kavita Juneja, Danielle Porter, Constance A Benson, Walla Dempsey, Hana M El Sahly, Chris Focht, Nikolaus Jilg, Catharine I Paules, Rekha R Rapaka, Timothy M Uyeki, H Clifford Lane, John Beigel, Lori E Dodd, Unknown, Aneesh K Mehta, Nadine G Rouphael, Jessica J Traenkner, Valeria D Cantos, Ghina Alaaeddine, Barry S Zingman, Robert Grossberg, Paul F Riska, Elizabeth Hohmann, Mariam Torres-Soto, Nikolaus Jilg, Helen Y Chu, Anna Wald, Margaret Green, Annie Luetkemeyer, Pierre-Cedric B Crouch, Hannah Jang, Susan Kline, Joanne Billings, Brooke Noren, Diego Lopez de Castilla, Jason W Van Winkle, Francis X Riedo, Robert W Finberg, Jennifer P Wang, Mireya Wessolossky, Kerry Dierberg, Benjamin Eckhardt, Henry J Neumann, Victor Tapson, Jonathan Grein, Fayyaz Sutterwala, Lanny Hsieh, Alpesh N Amin, Thomas F Patterson, Heta Javeri, Trung Vu, Roger Paredes, Lourdes Mateu, Daniel A Sweeney, Constance A Benson, Farhana Ali, William R Short, Pablo Tebas, Jessie Torgersen, Giota Touloumi, Vicky Gioukari, David Chien Lye, Sean W X Ong, Norio Ohmagari, Ayako Mikami, Gerd Fätkenheuer, Jakob J Malin, Philipp Koehler, Andre C Kalil, LuAnn Larson, Angela Hewlett, Mark G Kortepeter, C Buddy Creech, Isaac Thomsen, Todd W Rice, Babafemi Taiwo, Karen Krueger, Stuart H Cohen, George R Thompson, Cameron Wolfe, Emmanuel B Walter, Maria Frank, Heather Young, Ann R Falsey, Angela R Branche, Paul Goepfert, Nathaniel Erdmann, Otto O Yang, Jenny Ahn, Anna Goodman, Blair Merrick, Richard M Novak, Andrea Wendrow, Henry Arguinchona, Christa Arguinchona, Sarah L George, Janice Tennant, Robert L Atmar, Hana M El Sahly, Jennifer Whitaker, D Ashley Price, Christopher J A Duncan, Simeon Metallidis, Theofilos Chrysanthidis, F McLellan, Myoung-don Oh, Wan Beom Park, Eu Suk Kim, Jongtak Jung, Justin R Ortiz, Karen L Kotloff, Brian Angus, Jack David Germain Seymour, Noreen A Hynes, Lauren M Sauer, Neera Ahuja, Kari Nadeau, Patrick E H Jackson, Taison D Bell, Anastasia Antoniadou, Konstantinos Protopapas, Richard T Davey, Jocelyn D Voell, Jose Muñoz, Montserrat Roldan, Ioannis Kalomenidis, Spyros G Zakynthinos, Catharine I Paules, Fiona McGill, Jane Minton, Nikolaos Koulouris, Zafeiria Barmparessou, Edwin Swiatlo, Kyle Widmer, Nikhil Huprikar, Anuradha Ganesan, Guillermo M Ruiz-Palacios, Alfredo Ponce de León, Sandra Rajme, Justino Regalado Pineda, José Arturo Martinez-Orozco, Mark Holodniy, Aarthi Chary, Timo Wolf, Christoph Stephan, Jan-Christian Wasmuth, Christoph Boesecke, Martin Llewelyn, Barbara Philips, Christopher J Colombo, Rhonda E Colombo, David A Lindholm, Katrin Mende, Tida Lee, Tahaniyat Lalani, Ryan C Maves, Gregory C Utz, Jens Lundgren, Marie Helleberg, Jan Gerstoft, Thomas Benfield, Tomas Jensen, Birgitte Lindegaard, Lothar Weise, Lene Knudsen, Isik Johansen, Lone W Madsen, Lars Østergaard, Nina Stærke, Henrik Nielsen, Timothy H Burgess, Michelle Green, Mat Makowski, Jennifer L Ferreira, Michael R Wierzbicki, Tyler Bonnett, Nikki Gettinger, Theresa Engel, Jing Wang, John H Beigel, Kay M Tomashek, Seema Nayak, Lori E Dodd, Walla Dempsey, Effie Nomicos, Marina Lee, Peter Wolff, Rhonda Pikaart-Tautges, Mohamed Elsafy, Robert Jurao, Hyung Koo, Michael Proschan, Dean Follmann, H Clifford Lane

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DOI: 10.1093/infdis/jiae198
Published: 2024-04-24
Container: The Journal of Infectious Diseases
Publisher: Oxford University Press (OUP)
Open access: unknown

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BibTeX

@article{allodium:10.1093/infdis/jiae198,
  title = {SARS-CoV-2 RNA and Nucleocapsid Antigen Are Blood Biomarkers Associated With Severe Disease Outcomes That Improve in Response to Remdesivir},
  author = {Kanal Singh and Kevin Rubenstein and Viviane Callier and Katy Shaw-Saliba and Adam Rupert and Robin Dewar and Sylvain Laverdure and Helene Highbarger and Perrine Lallemand and Meei-Li Huang and Keith R Jerome and Reigran Sampoleo and Margaret G Mills and Alexander L Greninger and Kavita Juneja and Danielle Porter and Constance A Benson and Walla Dempsey and Hana M El Sahly and Chris Focht and Nikolaus Jilg and Catharine I Paules and Rekha R Rapaka and Timothy M Uyeki and H Clifford Lane and John Beigel and Lori E Dodd and Unknown and Aneesh K Mehta and Nadine G Rouphael and Jessica J Traenkner and Valeria D Cantos and Ghina Alaaeddine and Barry S Zingman and Robert Grossberg and Paul F Riska and Elizabeth Hohmann and Mariam Torres-Soto and Nikolaus Jilg and Helen Y Chu and Anna Wald and Margaret Green and Annie Luetkemeyer and Pierre-Cedric B Crouch and Hannah Jang and Susan Kline and Joanne Billings and Brooke Noren and Diego Lopez de Castilla and Jason W Van Winkle and Francis X Riedo and Robert W Finberg and Jennifer P Wang and Mireya Wessolossky and Kerry Dierberg and Benjamin Eckhardt and Henry J Neumann and Victor Tapson and Jonathan Grein and Fayyaz Sutterwala and Lanny Hsieh and Alpesh N Amin and Thomas F Patterson and Heta Javeri and Trung Vu and Roger Paredes and Lourdes Mateu and Daniel A Sweeney and Constance A Benson and Farhana Ali and William R Short and Pablo Tebas and Jessie Torgersen and Giota Touloumi and Vicky Gioukari and David Chien Lye and Sean W X Ong and Norio Ohmagari and Ayako Mikami and Gerd Fätkenheuer and Jakob J Malin and Philipp Koehler and Andre C Kalil and LuAnn Larson and Angela Hewlett and Mark G Kortepeter and C Buddy Creech and Isaac Thomsen and Todd W Rice and Babafemi Taiwo and Karen Krueger and Stuart H Cohen and George R Thompson and Cameron Wolfe and Emmanuel B Walter and Maria Frank and Heather Young and Ann R Falsey and Angela R Branche and Paul Goepfert and Nathaniel Erdmann and Otto O Yang and Jenny Ahn and Anna Goodman and Blair Merrick and Richard M Novak and Andrea Wendrow and Henry Arguinchona and Christa Arguinchona and Sarah L George and Janice Tennant and Robert L Atmar and Hana M El Sahly and Jennifer Whitaker and D Ashley Price and Christopher J A Duncan and Simeon Metallidis and Theofilos Chrysanthidis and F McLellan and Myoung-don Oh and Wan Beom Park and Eu Suk Kim and Jongtak Jung and Justin R Ortiz and Karen L Kotloff and Brian Angus and Jack David Germain Seymour and Noreen A Hynes and Lauren M Sauer and Neera Ahuja and Kari Nadeau and Patrick E H Jackson and Taison D Bell and Anastasia Antoniadou and Konstantinos Protopapas and Richard T Davey and Jocelyn D Voell and Jose Muñoz and Montserrat Roldan and Ioannis Kalomenidis and Spyros G Zakynthinos and Catharine I Paules and Fiona McGill and Jane Minton and Nikolaos Koulouris and Zafeiria Barmparessou and Edwin Swiatlo and Kyle Widmer and Nikhil Huprikar and Anuradha Ganesan and Guillermo M Ruiz-Palacios and Alfredo Ponce de León and Sandra Rajme and Justino Regalado Pineda and José Arturo Martinez-Orozco and Mark Holodniy and Aarthi Chary and Timo Wolf and Christoph Stephan and Jan-Christian Wasmuth and Christoph Boesecke and Martin Llewelyn and Barbara Philips and Christopher J Colombo and Rhonda E Colombo and David A Lindholm and Katrin Mende and Tida Lee and Tahaniyat Lalani and Ryan C Maves and Gregory C Utz and Jens Lundgren and Marie Helleberg and Jan Gerstoft and Thomas Benfield and Tomas Jensen and Birgitte Lindegaard and Lothar Weise and Lene Knudsen and Isik Johansen and Lone W Madsen and Lars Østergaard and Nina Stærke and Henrik Nielsen and Timothy H Burgess and Michelle Green and Mat Makowski and Jennifer L Ferreira and Michael R Wierzbicki and Tyler Bonnett and Nikki Gettinger and Theresa Engel and Jing Wang and John H Beigel and Kay M Tomashek and Seema Nayak and Lori E Dodd and Walla Dempsey and Effie Nomicos and Marina Lee and Peter Wolff and Rhonda Pikaart-Tautges and Mohamed Elsafy and Robert Jurao and Hyung Koo and Michael Proschan and Dean Follmann and H Clifford Lane},
  year = {2024},
  journal = {The Journal of Infectious Diseases},
  doi = {10.1093/infdis/jiae198},
  url = {https://doi.org/10.1093/infdis/jiae198}
}

RIS

TY  - JOUR
TI  - SARS-CoV-2 RNA and Nucleocapsid Antigen Are Blood Biomarkers Associated With Severe Disease Outcomes That Improve in Response to Remdesivir
AU  - Kanal Singh
AU  - Kevin Rubenstein
AU  - Viviane Callier
AU  - Katy Shaw-Saliba
AU  - Adam Rupert
AU  - Robin Dewar
AU  - Sylvain Laverdure
AU  - Helene Highbarger
AU  - Perrine Lallemand
AU  - Meei-Li Huang
AU  - Keith R Jerome
AU  - Reigran Sampoleo
AU  - Margaret G Mills
AU  - Alexander L Greninger
AU  - Kavita Juneja
AU  - Danielle Porter
AU  - Constance A Benson
AU  - Walla Dempsey
AU  - Hana M El Sahly
AU  - Chris Focht
AU  - Nikolaus Jilg
AU  - Catharine I Paules
AU  - Rekha R Rapaka
AU  - Timothy M Uyeki
AU  - H Clifford Lane
AU  - John Beigel
AU  - Lori E Dodd
AU  - Unknown
AU  - Aneesh K Mehta
AU  - Nadine G Rouphael
AU  - Jessica J Traenkner
AU  - Valeria D Cantos
AU  - Ghina Alaaeddine
AU  - Barry S Zingman
AU  - Robert Grossberg
AU  - Paul F Riska
AU  - Elizabeth Hohmann
AU  - Mariam Torres-Soto
AU  - Nikolaus Jilg
AU  - Helen Y Chu
AU  - Anna Wald
AU  - Margaret Green
AU  - Annie Luetkemeyer
AU  - Pierre-Cedric B Crouch
AU  - Hannah Jang
AU  - Susan Kline
AU  - Joanne Billings
AU  - Brooke Noren
AU  - Diego Lopez de Castilla
AU  - Jason W Van Winkle
AU  - Francis X Riedo
AU  - Robert W Finberg
AU  - Jennifer P Wang
AU  - Mireya Wessolossky
AU  - Kerry Dierberg
AU  - Benjamin Eckhardt
AU  - Henry J Neumann
AU  - Victor Tapson
AU  - Jonathan Grein
AU  - Fayyaz Sutterwala
AU  - Lanny Hsieh
AU  - Alpesh N Amin
AU  - Thomas F Patterson
AU  - Heta Javeri
AU  - Trung Vu
AU  - Roger Paredes
AU  - Lourdes Mateu
AU  - Daniel A Sweeney
AU  - Constance A Benson
AU  - Farhana Ali
AU  - William R Short
AU  - Pablo Tebas
AU  - Jessie Torgersen
AU  - Giota Touloumi
AU  - Vicky Gioukari
AU  - David Chien Lye
AU  - Sean W X Ong
AU  - Norio Ohmagari
AU  - Ayako Mikami
AU  - Gerd Fätkenheuer
AU  - Jakob J Malin
AU  - Philipp Koehler
AU  - Andre C Kalil
AU  - LuAnn Larson
AU  - Angela Hewlett
AU  - Mark G Kortepeter
AU  - C Buddy Creech
AU  - Isaac Thomsen
AU  - Todd W Rice
AU  - Babafemi Taiwo
AU  - Karen Krueger
AU  - Stuart H Cohen
AU  - George R Thompson
AU  - Cameron Wolfe
AU  - Emmanuel B Walter
AU  - Maria Frank
AU  - Heather Young
AU  - Ann R Falsey
AU  - Angela R Branche
AU  - Paul Goepfert
AU  - Nathaniel Erdmann
AU  - Otto O Yang
AU  - Jenny Ahn
AU  - Anna Goodman
AU  - Blair Merrick
AU  - Richard M Novak
AU  - Andrea Wendrow
AU  - Henry Arguinchona
AU  - Christa Arguinchona
AU  - Sarah L George
AU  - Janice Tennant
AU  - Robert L Atmar
AU  - Hana M El Sahly
AU  - Jennifer Whitaker
AU  - D Ashley Price
AU  - Christopher J A Duncan
AU  - Simeon Metallidis
AU  - Theofilos Chrysanthidis
AU  - F McLellan
AU  - Myoung-don Oh
AU  - Wan Beom Park
AU  - Eu Suk Kim
AU  - Jongtak Jung
AU  - Justin R Ortiz
AU  - Karen L Kotloff
AU  - Brian Angus
AU  - Jack David Germain Seymour
AU  - Noreen A Hynes
AU  - Lauren M Sauer
AU  - Neera Ahuja
AU  - Kari Nadeau
AU  - Patrick E H Jackson
AU  - Taison D Bell
AU  - Anastasia Antoniadou
AU  - Konstantinos Protopapas
AU  - Richard T Davey
AU  - Jocelyn D Voell
AU  - Jose Muñoz
AU  - Montserrat Roldan
AU  - Ioannis Kalomenidis
AU  - Spyros G Zakynthinos
AU  - Catharine I Paules
AU  - Fiona McGill
AU  - Jane Minton
AU  - Nikolaos Koulouris
AU  - Zafeiria Barmparessou
AU  - Edwin Swiatlo
AU  - Kyle Widmer
AU  - Nikhil Huprikar
AU  - Anuradha Ganesan
AU  - Guillermo M Ruiz-Palacios
AU  - Alfredo Ponce de León
AU  - Sandra Rajme
AU  - Justino Regalado Pineda
AU  - José Arturo Martinez-Orozco
AU  - Mark Holodniy
AU  - Aarthi Chary
AU  - Timo Wolf
AU  - Christoph Stephan
AU  - Jan-Christian Wasmuth
AU  - Christoph Boesecke
AU  - Martin Llewelyn
AU  - Barbara Philips
AU  - Christopher J Colombo
AU  - Rhonda E Colombo
AU  - David A Lindholm
AU  - Katrin Mende
AU  - Tida Lee
AU  - Tahaniyat Lalani
AU  - Ryan C Maves
AU  - Gregory C Utz
AU  - Jens Lundgren
AU  - Marie Helleberg
AU  - Jan Gerstoft
AU  - Thomas Benfield
AU  - Tomas Jensen
AU  - Birgitte Lindegaard
AU  - Lothar Weise
AU  - Lene Knudsen
AU  - Isik Johansen
AU  - Lone W Madsen
AU  - Lars Østergaard
AU  - Nina Stærke
AU  - Henrik Nielsen
AU  - Timothy H Burgess
AU  - Michelle Green
AU  - Mat Makowski
AU  - Jennifer L Ferreira
AU  - Michael R Wierzbicki
AU  - Tyler Bonnett
AU  - Nikki Gettinger
AU  - Theresa Engel
AU  - Jing Wang
AU  - John H Beigel
AU  - Kay M Tomashek
AU  - Seema Nayak
AU  - Lori E Dodd
AU  - Walla Dempsey
AU  - Effie Nomicos
AU  - Marina Lee
AU  - Peter Wolff
AU  - Rhonda Pikaart-Tautges
AU  - Mohamed Elsafy
AU  - Robert Jurao
AU  - Hyung Koo
AU  - Michael Proschan
AU  - Dean Follmann
AU  - H Clifford Lane
PY  - 2024
JO  - The Journal of Infectious Diseases
DO  - 10.1093/infdis/jiae198
UR  - https://doi.org/10.1093/infdis/jiae198
ER  -

APA

Singh, K., Rubenstein, K., Callier, V., Shaw-Saliba, K., Rupert, A., Dewar, R., Laverdure, S., Highbarger, H., Lallemand, P., Huang, M., Jerome, K. R., Sampoleo, R., Mills, M. G., Greninger, A. L., Juneja, K., Porter, D., Benson, C. A., Dempsey, W., Sahly, H. M. E., Focht, C., Jilg, N., Paules, C. I., Rapaka, R. R., Uyeki, T. M., Lane, H. C., Beigel, J., Dodd, L. E., Unknown, Mehta, A. K., Rouphael, N. G., Traenkner, J. J., Cantos, V. D., Alaaeddine, G., Zingman, B. S., Grossberg, R., Riska, P. F., Hohmann, E., Torres-Soto, M., Jilg, N., Chu, H. Y., Wald, A., Green, M., Luetkemeyer, A., Crouch, P. B., Jang, H., Kline, S., Billings, J., Noren, B., Castilla, D. L. D., Winkle, J. W. V., Riedo, F. X., Finberg, R. W., Wang, J. P., Wessolossky, M., Dierberg, K., Eckhardt, B., Neumann, H. J., Tapson, V., Grein, J., Sutterwala, F., Hsieh, L., Amin, A. N., Patterson, T. F., Javeri, H., Vu, T., Paredes, R., Mateu, L., Sweeney, D. A., Benson, C. A., Ali, F., Short, W. R., Tebas, P., Torgersen, J., Touloumi, G., Gioukari, V., Lye, D. C., Ong, S. W. X., Ohmagari, N., Mikami, A., Fätkenheuer, G., Malin, J. J., Koehler, P., Kalil, A. C., Larson, L., Hewlett, A., Kortepeter, M. G., Creech, C. B., Thomsen, I., Rice, T. W., Taiwo, B., Krueger, K., Cohen, S. H., Thompson, G. R., Wolfe, C., Walter, E. B., Frank, M., Young, H., Falsey, A. R., Branche, A. R., Goepfert, P., Erdmann, N., Yang, O. O., Ahn, J., Goodman, A., Merrick, B., Novak, R. M., Wendrow, A., Arguinchona, H., Arguinchona, C., George, S. L., Tennant, J., Atmar, R. L., Sahly, H. M. E., Whitaker, J., Price, D. A., Duncan, C. J. A., Metallidis, S., Chrysanthidis, T., McLellan, F., Oh, M., Park, W. B., Kim, E. S., Jung, J., Ortiz, J. R., Kotloff, K. L., Angus, B., Seymour, J. D. G., Hynes, N. A., Sauer, L. M., Ahuja, N., Nadeau, K., Jackson, P. E. H., Bell, T. D., Antoniadou, A., Protopapas, K., Davey, R. T., Voell, J. D., Muñoz, J., Roldan, M., Kalomenidis, I., Zakynthinos, S. G., Paules, C. I., McGill, F., Minton, J., Koulouris, N., Barmparessou, Z., Swiatlo, E., Widmer, K., Huprikar, N., Ganesan, A., Ruiz-Palacios, G. M., León, A. P. D., Rajme, S., Pineda, J. R., Martinez-Orozco, J. A., Holodniy, M., Chary, A., Wolf, T., Stephan, C., Wasmuth, J., Boesecke, C., Llewelyn, M., Philips, B., Colombo, C. J., Colombo, R. E., Lindholm, D. A., Mende, K., Lee, T., Lalani, T., Maves, R. C., Utz, G. C., Lundgren, J., Helleberg, M., Gerstoft, J., Benfield, T., Jensen, T., Lindegaard, B., Weise, L., Knudsen, L., Johansen, I., Madsen, L. W., Østergaard, L., Stærke, N., Nielsen, H., Burgess, T. H., Green, M., Makowski, M., Ferreira, J. L., Wierzbicki, M. R., Bonnett, T., Gettinger, N., Engel, T., Wang, J., Beigel, J. H., Tomashek, K. M., Nayak, S., Dodd, L. E., Dempsey, W., Nomicos, E., Lee, M., Wolff, P., Pikaart-Tautges, R., Elsafy, M., Jurao, R., Koo, H., Proschan, M., Follmann, D., & Lane, H. C. (2024). SARS-CoV-2 RNA and Nucleocapsid Antigen Are Blood Biomarkers Associated With Severe Disease Outcomes That Improve in Response to Remdesivir. The Journal of Infectious Diseases. https://doi.org/10.1093/infdis/jiae198

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crossref · retrieved 2026-09-27T08:33:45.705Z