Safety and Immunogenicity of a Severe Acute Respiratory Syndrome Coronavirus 2 Spike Subunit Vaccine Stabilized in the Prefusion Conformation by a Second-Generation Molecular Clamp and Evaluated in Adults Aged 18–55 Years: A Randomized, Double-Blind, Active Comparator, Phase I Trial

Keith J Chappell, Francesca L Mordant, Alberto A Amarilla, Naphak Modhiran, Benjamin Liang, Zheyi Li, Julia A Lackenby, Noushin Jaberolansar, Jake O’Donnell, Vivian Kienzle, Varsha Kommajosyula, Nicolas Tardiota, Jillian K Bennet, Christina L Henderson, Rhiannon L Dalrymple, Justin Goh, Kym Hoger, Marianne Gillard, Martina L Jones, Karen Hughes, Ben Hughes, James Barnes, Patrick C Reading, Charani Ranasinghe, Kanta Subbarao, Trent P Munro, Paul R Young, Daniel Watterson

Open source

DOI: 10.1093/infdis/jiaf568
Published: 2025-11-25
Container: The Journal of Infectious Diseases
Publisher: Oxford University Press (OUP)
Open access: unknown

Credibility signals

uncertain Score 64/100 under policy 1.0.0. This is a metadata assessment, not a judgment of the paper's conclusions.

Show all credibility signals

supportingDOI registered: A matching record was returned by Crossref. Source: Crossref; license: CC0 metadata
supportingDOI resolves: A matching record was returned by Crossref. Source: Crossref; license: CC0 metadata
not scoredDirectory of Open Access Journals: No matching DOAJ record was present in this response. No allow-list match; this is not evidence of low credibility. Source: DOAJ; license: CC0
not scoredMEDLINE indexed: Not checked or no result supplied; no credibility inference made. Source: No authority result supplied; license: Unknown
not scoredOpenAlex core source: Not checked or no result supplied; no credibility inference made. Source: No authority result supplied; license: Unknown
not scoredKnown publisher allow-list: Not checked or no result supplied; no credibility inference made. Source: No authority result supplied; license: Unknown
not scoredROR affiliation: Not checked or no result supplied; no credibility inference made. Source: No authority result supplied; license: Unknown
not scoredRetraction Watch retraction: No retraction notice matched this DOI in the deployed snapshot. No matching event found; coverage may be incomplete. Source: Retraction Watch; license: CC BY 4.0
not scoredRetraction Watch expression of concern: No expression of concern notice matched this DOI in the deployed snapshot. No matching event found; coverage may be incomplete. Source: Retraction Watch; license: CC BY 4.0
not scoredRetraction Watch correction: No correction notice matched this DOI in the deployed snapshot. No matching event found; coverage may be incomplete. Source: Retraction Watch; license: CC BY 4.0
not scoredRetraction Watch reinstatement: No reinstatement notice matched this DOI in the deployed snapshot. No matching event found; coverage may be incomplete. Source: Retraction Watch; license: CC BY 4.0
not scoredOpen access status: Not checked or no result supplied; no credibility inference made. Source: No authority result supplied; license: Unknown
not scoredPublication license: Not checked or no result supplied; no credibility inference made. Source: No authority result supplied; license: Unknown
not scoredPublication version: A publication version was supplied but is not scored. Source: Normalized work metadata; license: Caller-provided; provenance license not supplied to scorer
supportingMetadata completeness: All 6 scored descriptive metadata groups are present. Source: Normalized work metadata; license: Caller-provided; provenance license not supplied to scorer

Cite this work

BibTeX

@article{allodium:10.1093/infdis/jiaf568,
  title = {Safety and Immunogenicity of a Severe Acute Respiratory Syndrome Coronavirus 2 Spike Subunit Vaccine Stabilized in the Prefusion Conformation by a Second-Generation Molecular Clamp and Evaluated in Adults Aged 18–55 Years: A Randomized, Double-Blind, Active Comparator, Phase I Trial},
  author = {Keith J Chappell and Francesca L Mordant and Alberto A Amarilla and Naphak Modhiran and Benjamin Liang and Zheyi Li and Julia A Lackenby and Noushin Jaberolansar and Jake O’Donnell and Vivian Kienzle and Varsha Kommajosyula and Nicolas Tardiota and Jillian K Bennet and Christina L Henderson and Rhiannon L Dalrymple and Justin Goh and Kym Hoger and Marianne Gillard and Martina L Jones and Karen Hughes and Ben Hughes and James Barnes and Patrick C Reading and Charani Ranasinghe and Kanta Subbarao and Trent P Munro and Paul R Young and Daniel Watterson},
  year = {2025},
  journal = {The Journal of Infectious Diseases},
  doi = {10.1093/infdis/jiaf568},
  url = {https://doi.org/10.1093/infdis/jiaf568}
}

RIS

TY  - JOUR
TI  - Safety and Immunogenicity of a Severe Acute Respiratory Syndrome Coronavirus 2 Spike Subunit Vaccine Stabilized in the Prefusion Conformation by a Second-Generation Molecular Clamp and Evaluated in Adults Aged 18–55 Years: A Randomized, Double-Blind, Active Comparator, Phase I Trial
AU  - Keith J Chappell
AU  - Francesca L Mordant
AU  - Alberto A Amarilla
AU  - Naphak Modhiran
AU  - Benjamin Liang
AU  - Zheyi Li
AU  - Julia A Lackenby
AU  - Noushin Jaberolansar
AU  - Jake O’Donnell
AU  - Vivian Kienzle
AU  - Varsha Kommajosyula
AU  - Nicolas Tardiota
AU  - Jillian K Bennet
AU  - Christina L Henderson
AU  - Rhiannon L Dalrymple
AU  - Justin Goh
AU  - Kym Hoger
AU  - Marianne Gillard
AU  - Martina L Jones
AU  - Karen Hughes
AU  - Ben Hughes
AU  - James Barnes
AU  - Patrick C Reading
AU  - Charani Ranasinghe
AU  - Kanta Subbarao
AU  - Trent P Munro
AU  - Paul R Young
AU  - Daniel Watterson
PY  - 2025
JO  - The Journal of Infectious Diseases
DO  - 10.1093/infdis/jiaf568
UR  - https://doi.org/10.1093/infdis/jiaf568
ER  -

APA

Chappell, K. J., Mordant, F. L., Amarilla, A. A., Modhiran, N., Liang, B., Li, Z., Lackenby, J. A., Jaberolansar, N., O’Donnell, J., Kienzle, V., Kommajosyula, V., Tardiota, N., Bennet, J. K., Henderson, C. L., Dalrymple, R. L., Goh, J., Hoger, K., Gillard, M., Jones, M. L., Hughes, K., Hughes, B., Barnes, J., Reading, P. C., Ranasinghe, C., Subbarao, K., Munro, T. P., Young, P. R., & Watterson, D. (2025). Safety and Immunogenicity of a Severe Acute Respiratory Syndrome Coronavirus 2 Spike Subunit Vaccine Stabilized in the Prefusion Conformation by a Second-Generation Molecular Clamp and Evaluated in Adults Aged 18–55 Years: A Randomized, Double-Blind, Active Comparator, Phase I Trial. The Journal of Infectious Diseases. https://doi.org/10.1093/infdis/jiaf568

Source records

crossref · retrieved 2026-09-26T10:57:53.672Z