Genome-wide association study of major anxiety disorders in 122,341 European-ancestry cases identifies 58 loci and highlights GABAergic signaling

Nora I. Strom, Brad Verhulst, Silviu-Alin Bacanu, Rosa Cheesman, Kirstin L. Purves, Hüseyin Gedik, Brittany L. Mitchell, Alex S. Kwong, Annika B. Faucon, Kritika Singh, Sarah Medland, Lucia Colodro-Conde, Kristi Krebs, Per Hoffmann, Stefan Herms, Jan Gehlen, Stephan Ripke, Swapnil Awasthi, Teemu Palviainen, Elisa M. Tasanko, Roseann E. Peterson, Daniel E. Adkins, Andrey A. Shabalin, Mark J. Adams, Matthew H. Iveson, Archie Campbell, Laurent F. Thomas, Bendik S. Winsvold, Ole Kristian Drange, Sigrid Børte, Abigail R. ter Kuile, Tan-Hoang Nguyen, Sandra M. Meier, Elizabeth C. Corfield, Laurie Hannigan, Daniel F. Levey, Darina Czamara, Heike Weber, Karmel W. Choi, Giorgio Pistis, Baptiste Couvy-Duchesne, Sandra Van der Auwera, Alexander Teumer, Robert Karlsson, Miguel Garcia-Argibay, Donghyung Lee, Rujia Wang, Ottar Bjerkeset, Eystein Stordal, Julia Bäckmann, Giovanni A. Salum, Clement C. Zai, James L. Kennedy, Gwyneth Zai, Arun K. Tiwari, Stefanie Heilmann-Heimbach, Börge Schmidt, Jaakko Kaprio, Martin M. Kennedy, Joseph Boden, Alexandra Havdahl, Christel M. Middeldorp, Fabiana L. Lopes, Nirmala Akula, Francis J. McMahon, Elisabeth B. Binder, Lydia Fehm, Andreas Ströhle, Enrique Castelao, Henning Tiemeier, Dan J. Stein, David Whiteman, Catherine Olsen, Zachary Fuller, Xin Wang, Naomi R. Wray, Enda M. Byrne, Glyn Lewis, Nicholas J. Timpson, Lea K. Davis, Ian B. Hickie, Nathan A. Gillespie, Lili Milani, Johannes Schumacher, David P. Woldbye, Andreas J. Forstner, Markus M. Nöthen, Iiris Hovatta, John Horwood, William E. Copeland, Hermine H. Maes, Andrew M. McIntosh, Ole A. Andreassen, John-Anker Zwart, Ole Mors, Anders D. Børglum, Preben B. Mortensen, Helga Ask, Ted Reichborn-Kjennerud, Jackob M. Najman, Murray B. Stein, Joel Gelernter, Yuri Milaneschi, Brenda W. Penninx, Dorret I. Boomsma, Eduard Maron, Angelika Erhardt-Lehmann, Christian Rück, Tilo T. Kircher, Christiane A. Melzig, Georg W. Alpers, Volker Arolt, Katharina Domschke, Jordan W. Smoller, Martin Preisig, Nicholas G. Martin, Michelle K. Lupton, Annemarie I. Luik, Andreas Reif, Hans J. Grabe, Henrik Larsson, Patrik K. Magnusson, Albertine J. Oldehinkel, Catharina A. Hartman, Gerome Breen, Anna R. Docherty, Hilary Coon, Rupert Conrad, Kelli Lehto, Unknown, Jürgen Deckert, Thalia C. Eley, Manuel Mattheisen, John M. Hettema

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DOI: 10.1101/2024.07.03.24309466
Published: 2024-07-05
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@article{allodium:10.1101/2024.07.03.24309466,
title = {Genome-wide association study of major anxiety disorders in 122,341 European-ancestry cases identifies 58 loci and highlights GABAergic signaling},
author = {Nora I. Strom and Brad Verhulst and Silviu-Alin Bacanu and Rosa Cheesman and Kirstin L. Purves and Hüseyin Gedik and Brittany L. Mitchell and Alex S. Kwong and Annika B. Faucon and Kritika Singh and Sarah Medland and Lucia Colodro-Conde and Kristi Krebs and Per Hoffmann and Stefan Herms and Jan Gehlen and Stephan Ripke and Swapnil Awasthi and Teemu Palviainen and Elisa M. Tasanko and Roseann E. Peterson and Daniel E. Adkins and Andrey A. Shabalin and Mark J. Adams and Matthew H. Iveson and Archie Campbell and Laurent F. Thomas and Bendik S. Winsvold and Ole Kristian Drange and Sigrid Børte and Abigail R. ter Kuile and Tan-Hoang Nguyen and Sandra M. Meier and Elizabeth C. Corfield and Laurie Hannigan and Daniel F. Levey and Darina Czamara and Heike Weber and Karmel W. Choi and Giorgio Pistis and Baptiste Couvy-Duchesne and Sandra Van der Auwera and Alexander Teumer and Robert Karlsson and Miguel Garcia-Argibay and Donghyung Lee and Rujia Wang and Ottar Bjerkeset and Eystein Stordal and Julia Bäckmann and Giovanni A. Salum and Clement C. Zai and James L. Kennedy and Gwyneth Zai and Arun K. Tiwari and Stefanie Heilmann-Heimbach and Börge Schmidt and Jaakko Kaprio and Martin M. Kennedy and Joseph Boden and Alexandra Havdahl and Christel M. Middeldorp and Fabiana L. Lopes and Nirmala Akula and Francis J. McMahon and Elisabeth B. Binder and Lydia Fehm and Andreas Ströhle and Enrique Castelao and Henning Tiemeier and Dan J. Stein and David Whiteman and Catherine Olsen and Zachary Fuller and Xin Wang and Naomi R. Wray and Enda M. Byrne and Glyn Lewis and Nicholas J. Timpson and Lea K. Davis and Ian B. Hickie and Nathan A. Gillespie and Lili Milani and Johannes Schumacher and David P. Woldbye and Andreas J. Forstner and Markus M. Nöthen and Iiris Hovatta and John Horwood and William E. Copeland and Hermine H. Maes and Andrew M. McIntosh and Ole A. Andreassen and John-Anker Zwart and Ole Mors and Anders D. Børglum and Preben B. Mortensen and Helga Ask and Ted Reichborn-Kjennerud and Jackob M. Najman and Murray B. Stein and Joel Gelernter and Yuri Milaneschi and Brenda W. Penninx and Dorret I. Boomsma and Eduard Maron and Angelika Erhardt-Lehmann and Christian Rück and Tilo T. Kircher and Christiane A. Melzig and Georg W. Alpers and Volker Arolt and Katharina Domschke and Jordan W. Smoller and Martin Preisig and Nicholas G. Martin and Michelle K. Lupton and Annemarie I. Luik and Andreas Reif and Hans J. Grabe and Henrik Larsson and Patrik K. Magnusson and Albertine J. Oldehinkel and Catharina A. Hartman and Gerome Breen and Anna R. Docherty and Hilary Coon and Rupert Conrad and Kelli Lehto and Unknown and Jürgen Deckert and Thalia C. Eley and Manuel Mattheisen and John M. Hettema},
year = {2024},
doi = {10.1101/2024.07.03.24309466},
url = {https://doi.org/10.1101/2024.07.03.24309466}
}

RIS

TY  - JOUR
TI  - Genome-wide association study of major anxiety disorders in 122,341 European-ancestry cases identifies 58 loci and highlights GABAergic signaling
AU  - Nora I. Strom
AU  - Brad Verhulst
AU  - Silviu-Alin Bacanu
AU  - Rosa Cheesman
AU  - Kirstin L. Purves
AU  - Hüseyin Gedik
AU  - Brittany L. Mitchell
AU  - Alex S. Kwong
AU  - Annika B. Faucon
AU  - Kritika Singh
AU  - Sarah Medland
AU  - Lucia Colodro-Conde
AU  - Kristi Krebs
AU  - Per Hoffmann
AU  - Stefan Herms
AU  - Jan Gehlen
AU  - Stephan Ripke
AU  - Swapnil Awasthi
AU  - Teemu Palviainen
AU  - Elisa M. Tasanko
AU  - Roseann E. Peterson
AU  - Daniel E. Adkins
AU  - Andrey A. Shabalin
AU  - Mark J. Adams
AU  - Matthew H. Iveson
AU  - Archie Campbell
AU  - Laurent F. Thomas
AU  - Bendik S. Winsvold
AU  - Ole Kristian Drange
AU  - Sigrid Børte
AU  - Abigail R. ter Kuile
AU  - Tan-Hoang Nguyen
AU  - Sandra M. Meier
AU  - Elizabeth C. Corfield
AU  - Laurie Hannigan
AU  - Daniel F. Levey
AU  - Darina Czamara
AU  - Heike Weber
AU  - Karmel W. Choi
AU  - Giorgio Pistis
AU  - Baptiste Couvy-Duchesne
AU  - Sandra Van der Auwera
AU  - Alexander Teumer
AU  - Robert Karlsson
AU  - Miguel Garcia-Argibay
AU  - Donghyung Lee
AU  - Rujia Wang
AU  - Ottar Bjerkeset
AU  - Eystein Stordal
AU  - Julia Bäckmann
AU  - Giovanni A. Salum
AU  - Clement C. Zai
AU  - James L. Kennedy
AU  - Gwyneth Zai
AU  - Arun K. Tiwari
AU  - Stefanie Heilmann-Heimbach
AU  - Börge Schmidt
AU  - Jaakko Kaprio
AU  - Martin M. Kennedy
AU  - Joseph Boden
AU  - Alexandra Havdahl
AU  - Christel M. Middeldorp
AU  - Fabiana L. Lopes
AU  - Nirmala Akula
AU  - Francis J. McMahon
AU  - Elisabeth B. Binder
AU  - Lydia Fehm
AU  - Andreas Ströhle
AU  - Enrique Castelao
AU  - Henning Tiemeier
AU  - Dan J. Stein
AU  - David Whiteman
AU  - Catherine Olsen
AU  - Zachary Fuller
AU  - Xin Wang
AU  - Naomi R. Wray
AU  - Enda M. Byrne
AU  - Glyn Lewis
AU  - Nicholas J. Timpson
AU  - Lea K. Davis
AU  - Ian B. Hickie
AU  - Nathan A. Gillespie
AU  - Lili Milani
AU  - Johannes Schumacher
AU  - David P. Woldbye
AU  - Andreas J. Forstner
AU  - Markus M. Nöthen
AU  - Iiris Hovatta
AU  - John Horwood
AU  - William E. Copeland
AU  - Hermine H. Maes
AU  - Andrew M. McIntosh
AU  - Ole A. Andreassen
AU  - John-Anker Zwart
AU  - Ole Mors
AU  - Anders D. Børglum
AU  - Preben B. Mortensen
AU  - Helga Ask
AU  - Ted Reichborn-Kjennerud
AU  - Jackob M. Najman
AU  - Murray B. Stein
AU  - Joel Gelernter
AU  - Yuri Milaneschi
AU  - Brenda W. Penninx
AU  - Dorret I. Boomsma
AU  - Eduard Maron
AU  - Angelika Erhardt-Lehmann
AU  - Christian Rück
AU  - Tilo T. Kircher
AU  - Christiane A. Melzig
AU  - Georg W. Alpers
AU  - Volker Arolt
AU  - Katharina Domschke
AU  - Jordan W. Smoller
AU  - Martin Preisig
AU  - Nicholas G. Martin
AU  - Michelle K. Lupton
AU  - Annemarie I. Luik
AU  - Andreas Reif
AU  - Hans J. Grabe
AU  - Henrik Larsson
AU  - Patrik K. Magnusson
AU  - Albertine J. Oldehinkel
AU  - Catharina A. Hartman
AU  - Gerome Breen
AU  - Anna R. Docherty
AU  - Hilary Coon
AU  - Rupert Conrad
AU  - Kelli Lehto
AU  - Unknown
AU  - Jürgen Deckert
AU  - Thalia C. Eley
AU  - Manuel Mattheisen
AU  - John M. Hettema
PY  - 2024
DO  - 10.1101/2024.07.03.24309466
UR  - https://doi.org/10.1101/2024.07.03.24309466
ER  -

APA

Strom, N. I., Verhulst, B., Bacanu, S., Cheesman, R., Purves, K. L., Gedik, H., Mitchell, B. L., Kwong, A. S., Faucon, A. B., Singh, K., Medland, S., Colodro-Conde, L., Krebs, K., Hoffmann, P., Herms, S., Gehlen, J., Ripke, S., Awasthi, S., Palviainen, T., Tasanko, E. M., Peterson, R. E., Adkins, D. E., Shabalin, A. A., Adams, M. J., Iveson, M. H., Campbell, A., Thomas, L. F., Winsvold, B. S., Drange, O. K., Børte, S., Kuile, A. R. T., Nguyen, T., Meier, S. M., Corfield, E. C., Hannigan, L., Levey, D. F., Czamara, D., Weber, H., Choi, K. W., Pistis, G., Couvy-Duchesne, B., Auwera, S. V. D., Teumer, A., Karlsson, R., Garcia-Argibay, M., Lee, D., Wang, R., Bjerkeset, O., Stordal, E., Bäckmann, J., Salum, G. A., Zai, C. C., Kennedy, J. L., Zai, G., Tiwari, A. K., Heilmann-Heimbach, S., Schmidt, B., Kaprio, J., Kennedy, M. M., Boden, J., Havdahl, A., Middeldorp, C. M., Lopes, F. L., Akula, N., McMahon, F. J., Binder, E. B., Fehm, L., Ströhle, A., Castelao, E., Tiemeier, H., Stein, D. J., Whiteman, D., Olsen, C., Fuller, Z., Wang, X., Wray, N. R., Byrne, E. M., Lewis, G., Timpson, N. J., Davis, L. K., Hickie, I. B., Gillespie, N. A., Milani, L., Schumacher, J., Woldbye, D. P., Forstner, A. J., Nöthen, M. M., Hovatta, I., Horwood, J., Copeland, W. E., Maes, H. H., McIntosh, A. M., Andreassen, O. A., Zwart, J., Mors, O., Børglum, A. D., Mortensen, P. B., Ask, H., Reichborn-Kjennerud, T., Najman, J. M., Stein, M. B., Gelernter, J., Milaneschi, Y., Penninx, B. W., Boomsma, D. I., Maron, E., Erhardt-Lehmann, A., Rück, C., Kircher, T. T., Melzig, C. A., Alpers, G. W., Arolt, V., Domschke, K., Smoller, J. W., Preisig, M., Martin, N. G., Lupton, M. K., Luik, A. I., Reif, A., Grabe, H. J., Larsson, H., Magnusson, P. K., Oldehinkel, A. J., Hartman, C. A., Breen, G., Docherty, A. R., Coon, H., Conrad, R., Lehto, K., Unknown, Deckert, J., Eley, T. C., Mattheisen, M., & Hettema, J. M. (2024). Genome-wide association study of major anxiety disorders in 122,341 European-ancestry cases identifies 58 loci and highlights GABAergic signaling. https://doi.org/10.1101/2024.07.03.24309466

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