Discovery of a Potent and Selective Inhibitor of Human NLRP3 with a Novel Binding Modality and Mechanism of Action

Kevin Wilhelmsen, Aditi Deshpande, Sarah Tronnes, Maitriyee Mahanta, Matthew Banicki, Mary Cochran, Samantha Cowdin, Kristen Fortney, George Hartman, Robert Hughes, Rusty Montgomery, Claudia Portillo, Paul Rubin, Yan Wang, Shijun Yan, Barry A Morgan, Assem Duisembekova, Romane Riou, Michael Marleaux, Inga V. Hochheiser, Hannes Buthmann, Dominic Ferber, Wei Wang, Melanie Cranston, Chloe M. McKee, Thea Mawhinney, Emma McKay, Bénédicte F. Py, Matthias Geyer, Rebecca C. Coll

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DOI: 10.1101/2024.12.21.629867
Published: 2024-12-22
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Publisher: openRxiv
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BibTeX

@article{allodium:10.1101/2024.12.21.629867,
  title = {Discovery of a Potent and Selective Inhibitor of Human NLRP3 with a Novel Binding Modality and Mechanism of Action},
  author = {Kevin Wilhelmsen and Aditi Deshpande and Sarah Tronnes and Maitriyee Mahanta and Matthew Banicki and Mary Cochran and Samantha Cowdin and Kristen Fortney and George Hartman and Robert Hughes and Rusty Montgomery and Claudia Portillo and Paul Rubin and Yan Wang and Shijun Yan and Barry A Morgan and Assem Duisembekova and Romane Riou and Michael Marleaux and Inga V. Hochheiser and Hannes Buthmann and Dominic Ferber and Wei Wang and Melanie Cranston and Chloe M. McKee and Thea Mawhinney and Emma McKay and Bénédicte F. Py and Matthias Geyer and Rebecca C. Coll},
  year = {2024},
  doi = {10.1101/2024.12.21.629867},
  url = {https://doi.org/10.1101/2024.12.21.629867}
}

RIS

TY  - JOUR
TI  - Discovery of a Potent and Selective Inhibitor of Human NLRP3 with a Novel Binding Modality and Mechanism of Action
AU  - Kevin Wilhelmsen
AU  - Aditi Deshpande
AU  - Sarah Tronnes
AU  - Maitriyee Mahanta
AU  - Matthew Banicki
AU  - Mary Cochran
AU  - Samantha Cowdin
AU  - Kristen Fortney
AU  - George Hartman
AU  - Robert Hughes
AU  - Rusty Montgomery
AU  - Claudia Portillo
AU  - Paul Rubin
AU  - Yan Wang
AU  - Shijun Yan
AU  - Barry A Morgan
AU  - Assem Duisembekova
AU  - Romane Riou
AU  - Michael Marleaux
AU  - Inga V. Hochheiser
AU  - Hannes Buthmann
AU  - Dominic Ferber
AU  - Wei Wang
AU  - Melanie Cranston
AU  - Chloe M. McKee
AU  - Thea Mawhinney
AU  - Emma McKay
AU  - Bénédicte F. Py
AU  - Matthias Geyer
AU  - Rebecca C. Coll
PY  - 2024
DO  - 10.1101/2024.12.21.629867
UR  - https://doi.org/10.1101/2024.12.21.629867
ER  -

APA

Wilhelmsen, K., Deshpande, A., Tronnes, S., Mahanta, M., Banicki, M., Cochran, M., Cowdin, S., Fortney, K., Hartman, G., Hughes, R., Montgomery, R., Portillo, C., Rubin, P., Wang, Y., Yan, S., Morgan, B. A., Duisembekova, A., Riou, R., Marleaux, M., Hochheiser, I. V., Buthmann, H., Ferber, D., Wang, W., Cranston, M., McKee, C. M., Mawhinney, T., McKay, E., Py, B. F., Geyer, M., & Coll, R. C. (2024). Discovery of a Potent and Selective Inhibitor of Human NLRP3 with a Novel Binding Modality and Mechanism of Action. https://doi.org/10.1101/2024.12.21.629867

Source records

crossref · retrieved 2026-09-25T23:49:00.145Z