Polygenic Hazard Score for Predicting Age-associated Risk of Alzheimer’s Disease in European Populations: Development and Validation

Akdeniz BC, Bahrami S, Hagen E, Fuhrer J, Fominykh V, Shadrin A, Filiz TT, Athanasiu L, Grenier-Boley B, Bellenguez C, de Rojas I, Küçükali F, Schneider A, Kleineidam L, Rujescu D, Scherbaum N, Deckert J, Riedel-Heller S, Hausner L, Molina-Porcel L, Grimmer T, Heilmann-Heimbach S, Moebus S, Scarmeas N, García-Alberca JM, Franco-Macías E, Mir P, Real LM, Rodriguez-Rodriguez E, Royo JL, Sáez ME, Carracedo Á, Lopez de Munain A, Amer-Ferrer G, Calero M, Medina M, Garcia-Ribas G, Mendioroz M, Dols-Icardo O, Moreno F, Pérez-Tur J, Bullido MJ, Álvarez V, Soininen H, Heikkinen S, de Mendonça A, Mehrabian S, Traykov L, Hort J, Vyhnalek M, Sandau N, Thomassen JQ, Luo J, Pijnenburg YA, Tesi N, van Swieten J, Giedraitis V, Williams J, Nicolas G, Debette S, Amouyel P, Grünblatt E, Popp J, Bossù P, Galimberti D, Rossi G, Arosio B, Mecocci P, Squassina A, Tremolizzo L, Borroni B, Nacmias B, Seripa D, Rainero I, Daniele A, Piras F, Masullo C, Kehoe PG, Frikke-Schmidt R, Ghidoni R, Ruiz A, Fernandez V, Sánchez-Juan P, Sleegers K, Ingelsson M, Hiltunen M, Sims R, Ramirez A, Broce IJ, Haavik J, Selbæk G, Knapskog A, Saltvedt I, Bergh S, Aakhus E, Kirsebom B, Watne LO, Rongve A, Årsland D, Djurovic S, Stordal E, Toft M, Scheffler K, Fladby T, Lambert J, Dale A, Frei O, Andreassen O.

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DOI: 10.1101/2025.07.28.25332293
Published: 2025-07-28
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Open access: yes

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Cite this work

BibTeX

@article{allodium:10.1101/2025.07.28.25332293,
  title = {Polygenic Hazard Score for Predicting Age-associated Risk of Alzheimer’s Disease in European Populations: Development and Validation},
  author = {Akdeniz BC and  Bahrami S and  Hagen E and  Fuhrer J and  Fominykh V and  Shadrin A and  Filiz TT and  Athanasiu L and  Grenier-Boley B and  Bellenguez C and  de Rojas I and  Küçükali F and  Schneider A and  Kleineidam L and  Rujescu D and  Scherbaum N and  Deckert J and  Riedel-Heller S and  Hausner L and  Molina-Porcel L and  Grimmer T and  Heilmann-Heimbach S and  Moebus S and  Scarmeas N and  García-Alberca JM and  Franco-Macías E and  Mir P and  Real LM and  Rodriguez-Rodriguez E and  Royo JL and  Sáez ME and  Carracedo Á and  Lopez de Munain A and  Amer-Ferrer G and  Calero M and  Medina M and  Garcia-Ribas G and  Mendioroz M and  Dols-Icardo O and  Moreno F and  Pérez-Tur J and  Bullido MJ and  Álvarez V and  Soininen H and  Heikkinen S and  de Mendonça A and  Mehrabian S and  Traykov L and  Hort J and  Vyhnalek M and  Sandau N and  Thomassen JQ and  Luo J and  Pijnenburg YA and  Tesi N and  van Swieten J and  Giedraitis V and  Williams J and  Nicolas G and  Debette S and  Amouyel P and  Grünblatt E and  Popp J and  Bossù P and  Galimberti D and  Rossi G and  Arosio B and  Mecocci P and  Squassina A and  Tremolizzo L and  Borroni B and  Nacmias B and  Seripa D and  Rainero I and  Daniele A and  Piras F and  Masullo C and  Kehoe PG and  Frikke-Schmidt R and  Ghidoni R and  Ruiz A and  Fernandez V and  Sánchez-Juan P and  Sleegers K and  Ingelsson M and  Hiltunen M and  Sims R and  Ramirez A and  Broce IJ and  Haavik J and  Selbæk G and  Knapskog A and  Saltvedt I and  Bergh S and  Aakhus E and  Kirsebom B and  Watne LO and  Rongve A and  Årsland D and  Djurovic S and  Stordal E and  Toft M and  Scheffler K and  Fladby T and  Lambert J and  Dale A and  Frei O and  Andreassen O.},
  year = {2025},
  doi = {10.1101/2025.07.28.25332293},
  url = {https://doi.org/10.1101/2025.07.28.25332293}
}

RIS

TY  - JOUR
TI  - Polygenic Hazard Score for Predicting Age-associated Risk of Alzheimer’s Disease in European Populations: Development and Validation
AU  - Akdeniz BC
AU  -  Bahrami S
AU  -  Hagen E
AU  -  Fuhrer J
AU  -  Fominykh V
AU  -  Shadrin A
AU  -  Filiz TT
AU  -  Athanasiu L
AU  -  Grenier-Boley B
AU  -  Bellenguez C
AU  -  de Rojas I
AU  -  Küçükali F
AU  -  Schneider A
AU  -  Kleineidam L
AU  -  Rujescu D
AU  -  Scherbaum N
AU  -  Deckert J
AU  -  Riedel-Heller S
AU  -  Hausner L
AU  -  Molina-Porcel L
AU  -  Grimmer T
AU  -  Heilmann-Heimbach S
AU  -  Moebus S
AU  -  Scarmeas N
AU  -  García-Alberca JM
AU  -  Franco-Macías E
AU  -  Mir P
AU  -  Real LM
AU  -  Rodriguez-Rodriguez E
AU  -  Royo JL
AU  -  Sáez ME
AU  -  Carracedo Á
AU  -  Lopez de Munain A
AU  -  Amer-Ferrer G
AU  -  Calero M
AU  -  Medina M
AU  -  Garcia-Ribas G
AU  -  Mendioroz M
AU  -  Dols-Icardo O
AU  -  Moreno F
AU  -  Pérez-Tur J
AU  -  Bullido MJ
AU  -  Álvarez V
AU  -  Soininen H
AU  -  Heikkinen S
AU  -  de Mendonça A
AU  -  Mehrabian S
AU  -  Traykov L
AU  -  Hort J
AU  -  Vyhnalek M
AU  -  Sandau N
AU  -  Thomassen JQ
AU  -  Luo J
AU  -  Pijnenburg YA
AU  -  Tesi N
AU  -  van Swieten J
AU  -  Giedraitis V
AU  -  Williams J
AU  -  Nicolas G
AU  -  Debette S
AU  -  Amouyel P
AU  -  Grünblatt E
AU  -  Popp J
AU  -  Bossù P
AU  -  Galimberti D
AU  -  Rossi G
AU  -  Arosio B
AU  -  Mecocci P
AU  -  Squassina A
AU  -  Tremolizzo L
AU  -  Borroni B
AU  -  Nacmias B
AU  -  Seripa D
AU  -  Rainero I
AU  -  Daniele A
AU  -  Piras F
AU  -  Masullo C
AU  -  Kehoe PG
AU  -  Frikke-Schmidt R
AU  -  Ghidoni R
AU  -  Ruiz A
AU  -  Fernandez V
AU  -  Sánchez-Juan P
AU  -  Sleegers K
AU  -  Ingelsson M
AU  -  Hiltunen M
AU  -  Sims R
AU  -  Ramirez A
AU  -  Broce IJ
AU  -  Haavik J
AU  -  Selbæk G
AU  -  Knapskog A
AU  -  Saltvedt I
AU  -  Bergh S
AU  -  Aakhus E
AU  -  Kirsebom B
AU  -  Watne LO
AU  -  Rongve A
AU  -  Årsland D
AU  -  Djurovic S
AU  -  Stordal E
AU  -  Toft M
AU  -  Scheffler K
AU  -  Fladby T
AU  -  Lambert J
AU  -  Dale A
AU  -  Frei O
AU  -  Andreassen O.
PY  - 2025
DO  - 10.1101/2025.07.28.25332293
UR  - https://doi.org/10.1101/2025.07.28.25332293
ER  -

APA

BC, A., S, B., E, H., J, F., V, F., A, S., TT, F., L, A., B, G., C, B., I, D. R., F, K., A, S., L, K., D, R., N, S., J, D., S, R., L, H., L, M., T, G., S, H., S, M., N, S., JM, G., E, F., P, M., LM, R., E, R., JL, R., ME, S., Á, C., A, L. D. M., G, A., M, C., M, M., G, G., M, M., O, D., F, M., J, P., MJ, B., V, Á., H, S., S, H., A, D. M., S, M., L, T., J, H., M, V., N, S., JQ, T., J, L., YA, P., N, T., J, V. S., V, G., J, W., G, N., S, D., P, A., E, G., J, P., P, B., D, G., G, R., B, A., P, M., A, S., L, T., B, B., B, N., D, S., I, R., A, D., F, P., C, M., PG, K., R, F., R, G., A, R., V, F., P, S., K, S., M, I., M, H., R, S., A, R., IJ, B., J, H., G, S., A, K., I, S., S, B., E, A., B, K., LO, W., A, R., D, Å., S, D., E, S., M, T., K, S., T, F., J, L., A, D., O, F., & O., A. (2025). Polygenic Hazard Score for Predicting Age-associated Risk of Alzheimer’s Disease in European Populations: Development and Validation. https://doi.org/10.1101/2025.07.28.25332293

Source records

europe-pmc · retrieved 2026-09-26T10:07:56.049Z