MK-8719, a Novel and Selective O-GlcNAcase Inhibitor That Reduces the Formation of Pathological Tau and Ameliorates Neurodegeneration in a Mouse Model of Tauopathy

Xiaohai Wang, Wenping Li, Jacob Marcus, Michelle Pearson, Lixin Song, Karen Smith, Giuseppe Terracina, Julie Lee, Kwok-Lam Karen Hong, Sherry X. Lu, Lynn Hyde, Shu-Cheng Chen, David Kinsley, Jerry P. Melchor, Daniel J. Rubins, Xiangjun Meng, Eric Hostetler, Cyrille Sur, Lili Zhang, Joel B. Schachter, J. Fred Hess, Harold G. Selnick, David J. Vocadlo, Ernest J. McEachern, Jason M. Uslaner, Joseph L. Duffy, Sean M. Smith

Open source

DOI: 10.1124/jpet.120.266122
Published: 2020-08
Container: The Journal of Pharmacology and Experimental Therapeutics
Publisher: Elsevier BV
Open access: unknown

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Cite this work

BibTeX

@article{allodium:10.1124/jpet.120.266122,
  title = {MK-8719, a Novel and Selective O-GlcNAcase Inhibitor That Reduces the Formation of Pathological Tau and Ameliorates Neurodegeneration in a Mouse Model of Tauopathy},
  author = {Xiaohai Wang and Wenping Li and Jacob Marcus and Michelle Pearson and Lixin Song and Karen Smith and Giuseppe Terracina and Julie Lee and Kwok-Lam Karen Hong and Sherry X. Lu and Lynn Hyde and Shu-Cheng Chen and David Kinsley and Jerry P. Melchor and Daniel J. Rubins and Xiangjun Meng and Eric Hostetler and Cyrille Sur and Lili Zhang and Joel B. Schachter and J. Fred Hess and Harold G. Selnick and David J. Vocadlo and Ernest J. McEachern and Jason M. Uslaner and Joseph L. Duffy and Sean M. Smith},
  year = {2020},
  journal = {The Journal of Pharmacology and Experimental Therapeutics},
  doi = {10.1124/jpet.120.266122},
  url = {https://doi.org/10.1124/jpet.120.266122}
}

RIS

TY  - JOUR
TI  - MK-8719, a Novel and Selective O-GlcNAcase Inhibitor That Reduces the Formation of Pathological Tau and Ameliorates Neurodegeneration in a Mouse Model of Tauopathy
AU  - Xiaohai Wang
AU  - Wenping Li
AU  - Jacob Marcus
AU  - Michelle Pearson
AU  - Lixin Song
AU  - Karen Smith
AU  - Giuseppe Terracina
AU  - Julie Lee
AU  - Kwok-Lam Karen Hong
AU  - Sherry X. Lu
AU  - Lynn Hyde
AU  - Shu-Cheng Chen
AU  - David Kinsley
AU  - Jerry P. Melchor
AU  - Daniel J. Rubins
AU  - Xiangjun Meng
AU  - Eric Hostetler
AU  - Cyrille Sur
AU  - Lili Zhang
AU  - Joel B. Schachter
AU  - J. Fred Hess
AU  - Harold G. Selnick
AU  - David J. Vocadlo
AU  - Ernest J. McEachern
AU  - Jason M. Uslaner
AU  - Joseph L. Duffy
AU  - Sean M. Smith
PY  - 2020
JO  - The Journal of Pharmacology and Experimental Therapeutics
DO  - 10.1124/jpet.120.266122
UR  - https://doi.org/10.1124/jpet.120.266122
ER  -

APA

Wang, X., Li, W., Marcus, J., Pearson, M., Song, L., Smith, K., Terracina, G., Lee, J., Hong, K. K., Lu, S. X., Hyde, L., Chen, S., Kinsley, D., Melchor, J. P., Rubins, D. J., Meng, X., Hostetler, E., Sur, C., Zhang, L., Schachter, J. B., Hess, J. F., Selnick, H. G., Vocadlo, D. J., McEachern, E. J., Uslaner, J. M., Duffy, J. L., & Smith, S. M. (2020). MK-8719, a Novel and Selective O-GlcNAcase Inhibitor That Reduces the Formation of Pathological Tau and Ameliorates Neurodegeneration in a Mouse Model of Tauopathy. The Journal of Pharmacology and Experimental Therapeutics. https://doi.org/10.1124/jpet.120.266122

Source records

crossref · retrieved 2026-09-26T12:18:38.720Z