Patient-derived organoids across cancers reveal conserved tumor heterogeneity and actionable therapeutic vulnerabilities.

Kuo HH, Bhinder B, Gokozan HN, Gorski K, Chandra P, Manohar J, Guevara D, Otilano J, Moyer J, Tranquille M, Ackermann S, Capuano J, Cheung C, Caiazza TA, Reuben PL, Tsomides AM, Irizarry A, Sigouros M, Wilkes D, King A, Kane T, Al Assaad M, Al Zoughbi W, Ohara K, Auh J, Waltman P, Madorsky Rowdo FP, Podaza E, Gallegos V, Nguyen J, Shah R, Shah M, Ocean A, Scherr D, Altorki N, Frey M, Molina AM, Newman L, Bea V, Chapman-Davis E, Goncalves MD, Saxena A, Shukla PJ, Holcomb K, Simmons R, Tagawa S, Zippin JH, Cantillo E, Chandwani R, Davis M, Garrett K, Kasi PM, Marti J, Nanus D, Nauseef JT, Popa E, Siddiqui MT, Alonso A, Sternberg CN, Faltas BM, Elemento O, Mosquera JM, Sboner A, Martin ML

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DOI: 10.1126/sciadv.adz3351
Published: 2026 Jun 26
Container: Science advances
Publisher: Not recorded
Open access: yes

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Cite this work

BibTeX

@article{allodium:10.1126/sciadv.adz3351,
  title = {Patient-derived organoids across cancers reveal conserved tumor heterogeneity and actionable therapeutic vulnerabilities.},
  author = {Kuo HH and Bhinder B and Gokozan HN and Gorski K and Chandra P and Manohar J and Guevara D and Otilano J and Moyer J and Tranquille M and Ackermann S and Capuano J and Cheung C and Caiazza TA and Reuben PL and Tsomides AM and Irizarry A and Sigouros M and Wilkes D and King A and Kane T and Al Assaad M and Al Zoughbi W and Ohara K and Auh J and Waltman P and Madorsky Rowdo FP and Podaza E and Gallegos V and Nguyen J and Shah R and Shah M and Ocean A and Scherr D and Altorki N and Frey M and Molina AM and Newman L and Bea V and Chapman-Davis E and Goncalves MD and Saxena A and Shukla PJ and Holcomb K and Simmons R and Tagawa S and Zippin JH and Cantillo E and Chandwani R and Davis M and Garrett K and Kasi PM and Marti J and Nanus D and Nauseef JT and Popa E and Siddiqui MT and Alonso A and Sternberg CN and Faltas BM and Elemento O and Mosquera JM and Sboner A and Martin ML},
  year = {2026},
  journal = {Science advances},
  doi = {10.1126/sciadv.adz3351},
  url = {https://doi.org/10.1126/sciadv.adz3351}
}

RIS

TY  - JOUR
TI  - Patient-derived organoids across cancers reveal conserved tumor heterogeneity and actionable therapeutic vulnerabilities.
AU  - Kuo HH
AU  - Bhinder B
AU  - Gokozan HN
AU  - Gorski K
AU  - Chandra P
AU  - Manohar J
AU  - Guevara D
AU  - Otilano J
AU  - Moyer J
AU  - Tranquille M
AU  - Ackermann S
AU  - Capuano J
AU  - Cheung C
AU  - Caiazza TA
AU  - Reuben PL
AU  - Tsomides AM
AU  - Irizarry A
AU  - Sigouros M
AU  - Wilkes D
AU  - King A
AU  - Kane T
AU  - Al Assaad M
AU  - Al Zoughbi W
AU  - Ohara K
AU  - Auh J
AU  - Waltman P
AU  - Madorsky Rowdo FP
AU  - Podaza E
AU  - Gallegos V
AU  - Nguyen J
AU  - Shah R
AU  - Shah M
AU  - Ocean A
AU  - Scherr D
AU  - Altorki N
AU  - Frey M
AU  - Molina AM
AU  - Newman L
AU  - Bea V
AU  - Chapman-Davis E
AU  - Goncalves MD
AU  - Saxena A
AU  - Shukla PJ
AU  - Holcomb K
AU  - Simmons R
AU  - Tagawa S
AU  - Zippin JH
AU  - Cantillo E
AU  - Chandwani R
AU  - Davis M
AU  - Garrett K
AU  - Kasi PM
AU  - Marti J
AU  - Nanus D
AU  - Nauseef JT
AU  - Popa E
AU  - Siddiqui MT
AU  - Alonso A
AU  - Sternberg CN
AU  - Faltas BM
AU  - Elemento O
AU  - Mosquera JM
AU  - Sboner A
AU  - Martin ML
PY  - 2026
JO  - Science advances
DO  - 10.1126/sciadv.adz3351
UR  - https://doi.org/10.1126/sciadv.adz3351
ER  -

APA

HH, K., B, B., HN, G., K, G., P, C., J, M., D, G., J, O., J, M., M, T., S, A., J, C., C, C., TA, C., PL, R., AM, T., A, I., M, S., D, W., A, K., T, K., M, A. A., W, A. Z., K, O., J, A., P, W., FP, M. R., E, P., V, G., J, N., R, S., M, S., A, O., D, S., N, A., M, F., AM, M., L, N., V, B., E, C., MD, G., A, S., PJ, S., K, H., R, S., S, T., JH, Z., E, C., R, C., M, D., K, G., PM, K., J, M., D, N., JT, N., E, P., MT, S., A, A., CN, S., BM, F., O, E., JM, M., A, S., & ML, M. (2026). Patient-derived organoids across cancers reveal conserved tumor heterogeneity and actionable therapeutic vulnerabilities.. Science advances. https://doi.org/10.1126/sciadv.adz3351

Source records

pubmed · retrieved 2026-09-25T04:29:46.310Z