Chemogenetic ubiquitin E1 inhibitor TAK-243 CRISPR screen uncovers HAPSTR1/HUWE1 axis in chromatin proteostasis and cell cycle control

Nila K. van Overbeek, Linda Clijsters, Martina Wirth, Ilona J. de Graaf, Klaas de Lint, Sidrit Uruci, Amina F. A. S. Teunisse, Vyacheslav Akimov, Arnoud H. de Ru, Maja Vukic, Idil Kirdök, Lucia Daxinger, Peter A. van Veelen, Blagoy Blagoev, Martijn S. Luijsterburg, Rob M. F. Wolthuis, Ilana Berlin, Alfred C. O. Vertegaal

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DOI: 10.1126/sciadv.aea3388
Published: 2026-10-16
Container: Science Advances
Publisher: American Association for the Advancement of Science (AAAS)
Open access: unknown

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Cite this work

BibTeX

@article{allodium:10.1126/sciadv.aea3388,
  title = {Chemogenetic ubiquitin E1 inhibitor TAK-243 CRISPR screen uncovers HAPSTR1/HUWE1 axis in chromatin proteostasis and cell cycle control},
  author = {Nila K. van Overbeek and Linda Clijsters and Martina Wirth and Ilona J. de Graaf and Klaas de Lint and Sidrit Uruci and Amina F. A. S. Teunisse and Vyacheslav Akimov and Arnoud H. de Ru and Maja Vukic and Idil Kirdök and Lucia Daxinger and Peter A. van Veelen and Blagoy Blagoev and Martijn S. Luijsterburg and Rob M. F. Wolthuis and Ilana Berlin and Alfred C. O. Vertegaal},
  year = {2026},
  journal = {Science Advances},
  doi = {10.1126/sciadv.aea3388},
  url = {https://doi.org/10.1126/sciadv.aea3388}
}

RIS

TY  - JOUR
TI  - Chemogenetic ubiquitin E1 inhibitor TAK-243 CRISPR screen uncovers HAPSTR1/HUWE1 axis in chromatin proteostasis and cell cycle control
AU  - Nila K. van Overbeek
AU  - Linda Clijsters
AU  - Martina Wirth
AU  - Ilona J. de Graaf
AU  - Klaas de Lint
AU  - Sidrit Uruci
AU  - Amina F. A. S. Teunisse
AU  - Vyacheslav Akimov
AU  - Arnoud H. de Ru
AU  - Maja Vukic
AU  - Idil Kirdök
AU  - Lucia Daxinger
AU  - Peter A. van Veelen
AU  - Blagoy Blagoev
AU  - Martijn S. Luijsterburg
AU  - Rob M. F. Wolthuis
AU  - Ilana Berlin
AU  - Alfred C. O. Vertegaal
PY  - 2026
JO  - Science Advances
DO  - 10.1126/sciadv.aea3388
UR  - https://doi.org/10.1126/sciadv.aea3388
ER  -

APA

Overbeek, N. K. V., Clijsters, L., Wirth, M., Graaf, I. J. D., Lint, K. D., Uruci, S., Teunisse, A. F. A. S., Akimov, V., Ru, A. H. D., Vukic, M., Kirdök, I., Daxinger, L., Veelen, P. A. V., Blagoev, B., Luijsterburg, M. S., Wolthuis, R. M. F., Berlin, I., & Vertegaal, A. C. O. (2026). Chemogenetic ubiquitin E1 inhibitor TAK-243 CRISPR screen uncovers HAPSTR1/HUWE1 axis in chromatin proteostasis and cell cycle control. Science Advances. https://doi.org/10.1126/sciadv.aea3388

Source records

crossref · retrieved 2026-11-03T09:51:38.715Z