Deep learning reveals a neurocomputational mechanism predicting depression risk in adolescents.

Lu H, Yan X, Becker B, Heinz A, Sahakian BJ, Langley C, Zuo Z, Cao L, Zhang Z, Robinson L, Vaidya N, Winterer J, King S, Walton C, Banaschewski T, Barker GJ, Bokde ALW, Brühl R, Flor H, Garavan H, Gowland P, Grigis A, Lemaitre H, Martinot JL, Martinot MP, Artiges E, Nees F, Orfanos DP, Poustka L, Kebir H, Schmidt U, Sinclair J, Smolka MN, Hohmann S, Holz N, Walter H, Whelan R, Desrivières S, Schumann G, Luo Q, STRATIFY/ESTRA Consortium, IMAGEN Consortium

Open source

DOI: 10.1126/sciadv.aed0772
Published: 2026 Aug 7
Container: Science advances
Publisher: Not recorded
Open access: yes

Credibility signals

limited evidence Score 45/100 under policy 1.0.0. This is a metadata assessment, not a judgment of the paper's conclusions.

Show all credibility signals

cautionDOI registered: No matching Crossref record was present in this response. Source: Crossref; license: CC0 metadata
cautionDOI resolves: No matching Crossref record was present in this response. Source: Crossref; license: CC0 metadata
not scoredDirectory of Open Access Journals: No matching DOAJ record was present in this response. No allow-list match; this is not evidence of low credibility. Source: DOAJ; license: CC0
not scoredMEDLINE indexed: Not checked or no result supplied; no credibility inference made. Source: No authority result supplied; license: Unknown
not scoredOpenAlex core source: Not checked or no result supplied; no credibility inference made. Source: No authority result supplied; license: Unknown
not scoredKnown publisher allow-list: Not checked or no result supplied; no credibility inference made. Source: No authority result supplied; license: Unknown
not scoredROR affiliation: Not checked or no result supplied; no credibility inference made. Source: No authority result supplied; license: Unknown
not scoredRetraction Watch retraction: No retraction notice matched this DOI in the deployed snapshot. No matching event found; coverage may be incomplete. Source: Retraction Watch; license: CC BY 4.0
not scoredRetraction Watch expression of concern: No expression of concern notice matched this DOI in the deployed snapshot. No matching event found; coverage may be incomplete. Source: Retraction Watch; license: CC BY 4.0
not scoredRetraction Watch correction: No correction notice matched this DOI in the deployed snapshot. No matching event found; coverage may be incomplete. Source: Retraction Watch; license: CC BY 4.0
not scoredRetraction Watch reinstatement: No reinstatement notice matched this DOI in the deployed snapshot. No matching event found; coverage may be incomplete. Source: Retraction Watch; license: CC BY 4.0
supportingOpen access status: Normalized open-access status: open. Source: Normalized work metadata; license: Caller-provided; provenance license not supplied to scorer
not scoredPublication license: Not checked or no result supplied; no credibility inference made. Source: No authority result supplied; license: Unknown
not scoredPublication version: A publication version was supplied but is not scored. Source: Normalized work metadata; license: Caller-provided; provenance license not supplied to scorer
cautionMetadata completeness: 5 of 6 scored descriptive metadata groups are present; missing fields increase uncertainty. Source: Normalized work metadata; license: Caller-provided; provenance license not supplied to scorer

Cite this work

BibTeX

@article{allodium:10.1126/sciadv.aed0772,
  title = {Deep learning reveals a neurocomputational mechanism predicting depression risk in adolescents.},
  author = {Lu H and Yan X and Becker B and Heinz A and Sahakian BJ and Langley C and Zuo Z and Cao L and Zhang Z and Robinson L and Vaidya N and Winterer J and King S and Walton C and Banaschewski T and Barker GJ and Bokde ALW and Brühl R and Flor H and Garavan H and Gowland P and Grigis A and Lemaitre H and Martinot JL and Martinot MP and Artiges E and Nees F and Orfanos DP and Poustka L and Kebir H and Schmidt U and Sinclair J and Smolka MN and Hohmann S and Holz N and Walter H and Whelan R and Desrivières S and Schumann G and Luo Q and STRATIFY/ESTRA Consortium and IMAGEN Consortium},
  year = {2026},
  journal = {Science advances},
  doi = {10.1126/sciadv.aed0772},
  url = {https://doi.org/10.1126/sciadv.aed0772}
}

RIS

TY  - JOUR
TI  - Deep learning reveals a neurocomputational mechanism predicting depression risk in adolescents.
AU  - Lu H
AU  - Yan X
AU  - Becker B
AU  - Heinz A
AU  - Sahakian BJ
AU  - Langley C
AU  - Zuo Z
AU  - Cao L
AU  - Zhang Z
AU  - Robinson L
AU  - Vaidya N
AU  - Winterer J
AU  - King S
AU  - Walton C
AU  - Banaschewski T
AU  - Barker GJ
AU  - Bokde ALW
AU  - Brühl R
AU  - Flor H
AU  - Garavan H
AU  - Gowland P
AU  - Grigis A
AU  - Lemaitre H
AU  - Martinot JL
AU  - Martinot MP
AU  - Artiges E
AU  - Nees F
AU  - Orfanos DP
AU  - Poustka L
AU  - Kebir H
AU  - Schmidt U
AU  - Sinclair J
AU  - Smolka MN
AU  - Hohmann S
AU  - Holz N
AU  - Walter H
AU  - Whelan R
AU  - Desrivières S
AU  - Schumann G
AU  - Luo Q
AU  - STRATIFY/ESTRA Consortium
AU  - IMAGEN Consortium
PY  - 2026
JO  - Science advances
DO  - 10.1126/sciadv.aed0772
UR  - https://doi.org/10.1126/sciadv.aed0772
ER  -

APA

H, L., X, Y., B, B., A, H., BJ, S., C, L., Z, Z., L, C., Z, Z., L, R., N, V., J, W., S, K., C, W., T, B., GJ, B., ALW, B., R, B., H, F., H, G., P, G., A, G., H, L., JL, M., MP, M., E, A., F, N., DP, O., L, P., H, K., U, S., J, S., MN, S., S, H., N, H., H, W., R, W., S, D., G, S., Q, L., Consortium, S., & Consortium, I. (2026). Deep learning reveals a neurocomputational mechanism predicting depression risk in adolescents.. Science advances. https://doi.org/10.1126/sciadv.aed0772

Source records

pubmed · retrieved 2026-09-24T21:32:56.575Z