Direct visualization of native GSDMD pores reveals lipid-driven stabilization during pyroptosis

Shirin Kappelhoff, Michael Holtmannspötter, Stefan L. Schaefer, Eleonora G. Margheritis, Özgün Doga Asik, Nadine Gehle, Hannah Veit, John S.H. Danial, Rico Franzkoch, Sebastian Strauss, Jonatan Alvelid, Agnes Koerfer, Christian Eggeling, Olympia E. Psathaki, Ralf Jungmann, Rainer Kurre, Gerhard Hummer, Jacob Piehler, Katia Cosentino

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DOI: 10.1126/sciadv.aee4587
Published: 2026-07-10
Container: Science Advances
Publisher: American Association for the Advancement of Science (AAAS)
Open access: unknown

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Cite this work

BibTeX

@article{allodium:10.1126/sciadv.aee4587,
  title = {Direct visualization of native GSDMD pores reveals lipid-driven stabilization during pyroptosis},
  author = {Shirin Kappelhoff and Michael Holtmannspötter and Stefan L. Schaefer and Eleonora G. Margheritis and Özgün Doga Asik and Nadine Gehle and Hannah Veit and John S.H. Danial and Rico Franzkoch and Sebastian Strauss and Jonatan Alvelid and Agnes Koerfer and Christian Eggeling and Olympia E. Psathaki and Ralf Jungmann and Rainer Kurre and Gerhard Hummer and Jacob Piehler and Katia Cosentino},
  year = {2026},
  journal = {Science Advances},
  doi = {10.1126/sciadv.aee4587},
  url = {https://doi.org/10.1126/sciadv.aee4587}
}

RIS

TY  - JOUR
TI  - Direct visualization of native GSDMD pores reveals lipid-driven stabilization during pyroptosis
AU  - Shirin Kappelhoff
AU  - Michael Holtmannspötter
AU  - Stefan L. Schaefer
AU  - Eleonora G. Margheritis
AU  - Özgün Doga Asik
AU  - Nadine Gehle
AU  - Hannah Veit
AU  - John S.H. Danial
AU  - Rico Franzkoch
AU  - Sebastian Strauss
AU  - Jonatan Alvelid
AU  - Agnes Koerfer
AU  - Christian Eggeling
AU  - Olympia E. Psathaki
AU  - Ralf Jungmann
AU  - Rainer Kurre
AU  - Gerhard Hummer
AU  - Jacob Piehler
AU  - Katia Cosentino
PY  - 2026
JO  - Science Advances
DO  - 10.1126/sciadv.aee4587
UR  - https://doi.org/10.1126/sciadv.aee4587
ER  -

APA

Kappelhoff, S., Holtmannspötter, M., Schaefer, S. L., Margheritis, E. G., Asik, Ö. D., Gehle, N., Veit, H., Danial, J. S., Franzkoch, R., Strauss, S., Alvelid, J., Koerfer, A., Eggeling, C., Psathaki, O. E., Jungmann, R., Kurre, R., Hummer, G., Piehler, J., & Cosentino, K. (2026). Direct visualization of native GSDMD pores reveals lipid-driven stabilization during pyroptosis. Science Advances. https://doi.org/10.1126/sciadv.aee4587

Source records

crossref · retrieved 2026-09-26T20:17:03.216Z