The myokine irisin ameliorates the secretory dysfunction of pancreatic β cells in experimental and human type 2 diabetes.

Marrano N, Borrelli A, Biondi G, Rella M, D'Oria R, Genchi VA, Caccioppoli C, Galasso V, Galluzzi G, Roberto L, Signorile A, Vincenti L, Aquilino F, Nano R, Baruzzi F, Moretti A, Lupo LG, Marchetti P, Piemonti L, Cignarelli A, Perrini S, Laviola L, Giorgino F, Natalicchio A

Open source

DOI: 10.1126/sciadv.aee4804
Published: 2026 Jun 5
Container: Science advances
Publisher: Not recorded
Open access: yes

Credibility signals

limited evidence Score 45/100 under policy 1.0.0. This is a metadata assessment, not a judgment of the paper's conclusions.

Show all credibility signals

cautionDOI registered: No matching Crossref record was present in this response. Source: Crossref; license: CC0 metadata
cautionDOI resolves: No matching Crossref record was present in this response. Source: Crossref; license: CC0 metadata
not scoredDirectory of Open Access Journals: No matching DOAJ record was present in this response. No allow-list match; this is not evidence of low credibility. Source: DOAJ; license: CC0
not scoredMEDLINE indexed: Not checked or no result supplied; no credibility inference made. Source: No authority result supplied; license: Unknown
not scoredOpenAlex core source: Not checked or no result supplied; no credibility inference made. Source: No authority result supplied; license: Unknown
not scoredKnown publisher allow-list: Not checked or no result supplied; no credibility inference made. Source: No authority result supplied; license: Unknown
not scoredROR affiliation: Not checked or no result supplied; no credibility inference made. Source: No authority result supplied; license: Unknown
not scoredRetraction Watch retraction: No retraction notice matched this DOI in the deployed snapshot. No matching event found; coverage may be incomplete. Source: Retraction Watch; license: CC BY 4.0
not scoredRetraction Watch expression of concern: No expression of concern notice matched this DOI in the deployed snapshot. No matching event found; coverage may be incomplete. Source: Retraction Watch; license: CC BY 4.0
not scoredRetraction Watch correction: No correction notice matched this DOI in the deployed snapshot. No matching event found; coverage may be incomplete. Source: Retraction Watch; license: CC BY 4.0
not scoredRetraction Watch reinstatement: No reinstatement notice matched this DOI in the deployed snapshot. No matching event found; coverage may be incomplete. Source: Retraction Watch; license: CC BY 4.0
supportingOpen access status: Normalized open-access status: open. Source: Normalized work metadata; license: Caller-provided; provenance license not supplied to scorer
not scoredPublication license: Not checked or no result supplied; no credibility inference made. Source: No authority result supplied; license: Unknown
not scoredPublication version: A publication version was supplied but is not scored. Source: Normalized work metadata; license: Caller-provided; provenance license not supplied to scorer
cautionMetadata completeness: 5 of 6 scored descriptive metadata groups are present; missing fields increase uncertainty. Source: Normalized work metadata; license: Caller-provided; provenance license not supplied to scorer

Cite this work

BibTeX

@article{allodium:10.1126/sciadv.aee4804,
  title = {The myokine irisin ameliorates the secretory dysfunction of pancreatic β cells in experimental and human type 2 diabetes.},
  author = {Marrano N and Borrelli A and Biondi G and Rella M and D'Oria R and Genchi VA and Caccioppoli C and Galasso V and Galluzzi G and Roberto L and Signorile A and Vincenti L and Aquilino F and Nano R and Baruzzi F and Moretti A and Lupo LG and Marchetti P and Piemonti L and Cignarelli A and Perrini S and Laviola L and Giorgino F and Natalicchio A},
  year = {2026},
  journal = {Science advances},
  doi = {10.1126/sciadv.aee4804},
  url = {https://doi.org/10.1126/sciadv.aee4804}
}

RIS

TY  - JOUR
TI  - The myokine irisin ameliorates the secretory dysfunction of pancreatic β cells in experimental and human type 2 diabetes.
AU  - Marrano N
AU  - Borrelli A
AU  - Biondi G
AU  - Rella M
AU  - D'Oria R
AU  - Genchi VA
AU  - Caccioppoli C
AU  - Galasso V
AU  - Galluzzi G
AU  - Roberto L
AU  - Signorile A
AU  - Vincenti L
AU  - Aquilino F
AU  - Nano R
AU  - Baruzzi F
AU  - Moretti A
AU  - Lupo LG
AU  - Marchetti P
AU  - Piemonti L
AU  - Cignarelli A
AU  - Perrini S
AU  - Laviola L
AU  - Giorgino F
AU  - Natalicchio A
PY  - 2026
JO  - Science advances
DO  - 10.1126/sciadv.aee4804
UR  - https://doi.org/10.1126/sciadv.aee4804
ER  -

APA

N, M., A, B., G, B., M, R., R, D., VA, G., C, C., V, G., G, G., L, R., A, S., L, V., F, A., R, N., F, B., A, M., LG, L., P, M., L, P., A, C., S, P., L, L., F, G., & A, N. (2026). The myokine irisin ameliorates the secretory dysfunction of pancreatic β cells in experimental and human type 2 diabetes.. Science advances. https://doi.org/10.1126/sciadv.aee4804

Source records

pubmed · retrieved 2026-09-26T23:50:02.884Z