The structure of the dopamine D(3) receptor bound to cariprazine reveals principles for partial agonists with designed pharmacology.

Hadas Yardeni E, Kiss DJ, Sanchez J, Shavit K, Szepesi Kovács D, Egyed A, Vogt CD, Gaitonde SA, Glenn J, Canals M, Bouvier M, Newman AH, Lane JR, Keserű GM, Shalev-Benami M

Open source

DOI: 10.1126/sciadv.aef7411
Published: 2026 Aug 28
Container: Science advances
Publisher: Not recorded
Open access: yes

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Cite this work

BibTeX

@article{allodium:10.1126/sciadv.aef7411,
  title = {The structure of the dopamine D(3) receptor bound to cariprazine reveals principles for partial agonists with designed pharmacology.},
  author = {Hadas Yardeni E and Kiss DJ and Sanchez J and Shavit K and Szepesi Kovács D and Egyed A and Vogt CD and Gaitonde SA and Glenn J and Canals M and Bouvier M and Newman AH and Lane JR and Keserű GM and Shalev-Benami M},
  year = {2026},
  journal = {Science advances},
  doi = {10.1126/sciadv.aef7411},
  url = {https://doi.org/10.1126/sciadv.aef7411}
}

RIS

TY  - JOUR
TI  - The structure of the dopamine D(3) receptor bound to cariprazine reveals principles for partial agonists with designed pharmacology.
AU  - Hadas Yardeni E
AU  - Kiss DJ
AU  - Sanchez J
AU  - Shavit K
AU  - Szepesi Kovács D
AU  - Egyed A
AU  - Vogt CD
AU  - Gaitonde SA
AU  - Glenn J
AU  - Canals M
AU  - Bouvier M
AU  - Newman AH
AU  - Lane JR
AU  - Keserű GM
AU  - Shalev-Benami M
PY  - 2026
JO  - Science advances
DO  - 10.1126/sciadv.aef7411
UR  - https://doi.org/10.1126/sciadv.aef7411
ER  -

APA

E, H. Y., DJ, K., J, S., K, S., D, S. K., A, E., CD, V., SA, G., J, G., M, C., M, B., AH, N., JR, L., GM, K., & M, S. (2026). The structure of the dopamine D(3) receptor bound to cariprazine reveals principles for partial agonists with designed pharmacology.. Science advances. https://doi.org/10.1126/sciadv.aef7411

Source records

pubmed · retrieved 2026-09-26T06:13:55.201Z