A transcriptional biosensor reveals mechanisms of α-ketoglutarate signaling to chromatin

Alex C. Sternisha, Haocheng Li, Kumar Gajendra, Yi Xiao, Xin Zhao, Jeffrey I. Traylor, Lei Guo, Ji Hyung Jun, Morgan Fleishman, Tracey Shipman, Vinesh T. Puliyappadamba, Pranita Kaphle, Qing Ouyang, Michael Schmidt, Diana D. Shi, Milan R. Savani, Alexander C.-Y. Tsai, Joyce H. Lee, Ruth Gordillo, Javier Garcia-Bermudez, Yoon Jung Kim, Shih-Chia Tso, Chad A. Brautigam, Lauren G. Zacharias, Thomas P. Mathews, Lin Xu, John G. Doench, Vidyasagar Koduri, Kalil G. Abdullah, Michalis Agathocleous, Laura A. Banaszynski, Ralph J. DeBerardinis, Eric M. Morrow, Samuel K. McBrayer

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DOI: 10.1126/science.adx8675
Published: 2026-07-16
Container: Science
Publisher: American Association for the Advancement of Science (AAAS)
Open access: unknown

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Cite this work

BibTeX

@article{allodium:10.1126/science.adx8675,
  title = {A transcriptional biosensor reveals mechanisms of α-ketoglutarate signaling to chromatin},
  author = {Alex C. Sternisha and Haocheng Li and Kumar Gajendra and Yi Xiao and Xin Zhao and Jeffrey I. Traylor and Lei Guo and Ji Hyung Jun and Morgan Fleishman and Tracey Shipman and Vinesh T. Puliyappadamba and Pranita Kaphle and Qing Ouyang and Michael Schmidt and Diana D. Shi and Milan R. Savani and Alexander C.-Y. Tsai and Joyce H. Lee and Ruth Gordillo and Javier Garcia-Bermudez and Yoon Jung Kim and Shih-Chia Tso and Chad A. Brautigam and Lauren G. Zacharias and Thomas P. Mathews and Lin Xu and John G. Doench and Vidyasagar Koduri and Kalil G. Abdullah and Michalis Agathocleous and Laura A. Banaszynski and Ralph J. DeBerardinis and Eric M. Morrow and Samuel K. McBrayer},
  year = {2026},
  journal = {Science},
  doi = {10.1126/science.adx8675},
  url = {https://doi.org/10.1126/science.adx8675}
}

RIS

TY  - JOUR
TI  - A transcriptional biosensor reveals mechanisms of α-ketoglutarate signaling to chromatin
AU  - Alex C. Sternisha
AU  - Haocheng Li
AU  - Kumar Gajendra
AU  - Yi Xiao
AU  - Xin Zhao
AU  - Jeffrey I. Traylor
AU  - Lei Guo
AU  - Ji Hyung Jun
AU  - Morgan Fleishman
AU  - Tracey Shipman
AU  - Vinesh T. Puliyappadamba
AU  - Pranita Kaphle
AU  - Qing Ouyang
AU  - Michael Schmidt
AU  - Diana D. Shi
AU  - Milan R. Savani
AU  - Alexander C.-Y. Tsai
AU  - Joyce H. Lee
AU  - Ruth Gordillo
AU  - Javier Garcia-Bermudez
AU  - Yoon Jung Kim
AU  - Shih-Chia Tso
AU  - Chad A. Brautigam
AU  - Lauren G. Zacharias
AU  - Thomas P. Mathews
AU  - Lin Xu
AU  - John G. Doench
AU  - Vidyasagar Koduri
AU  - Kalil G. Abdullah
AU  - Michalis Agathocleous
AU  - Laura A. Banaszynski
AU  - Ralph J. DeBerardinis
AU  - Eric M. Morrow
AU  - Samuel K. McBrayer
PY  - 2026
JO  - Science
DO  - 10.1126/science.adx8675
UR  - https://doi.org/10.1126/science.adx8675
ER  -

APA

Sternisha, A. C., Li, H., Gajendra, K., Xiao, Y., Zhao, X., Traylor, J. I., Guo, L., Jun, J. H., Fleishman, M., Shipman, T., Puliyappadamba, V. T., Kaphle, P., Ouyang, Q., Schmidt, M., Shi, D. D., Savani, M. R., Tsai, A. C., Lee, J. H., Gordillo, R., Garcia-Bermudez, J., Kim, Y. J., Tso, S., Brautigam, C. A., Zacharias, L. G., Mathews, T. P., Xu, L., Doench, J. G., Koduri, V., Abdullah, K. G., Agathocleous, M., Banaszynski, L. A., DeBerardinis, R. J., Morrow, E. M., & McBrayer, S. K. (2026). A transcriptional biosensor reveals mechanisms of α-ketoglutarate signaling to chromatin. Science. https://doi.org/10.1126/science.adx8675

Source records

crossref · retrieved 2026-09-26T02:53:48.701Z