Structure and evolution-guided design of minimal RNA-guided nucleases

Petr Skopintsev, Isabel Esain-Garcia, Evan C. DeTurk, Peter H. Yoon, Zehan Zhou, Trevor Weiss, Maris Kamalu, Ajit Chamraj, Kenneth J. Loi, Conner J. Langeberg, Ron S. Boger, Hunter Nisonoff, Hannah M. Karp, Lin-Xing Chen, Honglue Shi, Kamakshi Vohra, Jillian F. Banfield, Jamie H. D. Cate, Steven E. Jacobsen, Jennifer A. Doudna

Open source

DOI: 10.1126/science.aed6123
Published: 2026-07-16
Container: Science
Publisher: American Association for the Advancement of Science (AAAS)
Open access: unknown

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Cite this work

BibTeX

@article{allodium:10.1126/science.aed6123,
  title = {Structure and evolution-guided design of minimal RNA-guided nucleases},
  author = {Petr Skopintsev and Isabel Esain-Garcia and Evan C. DeTurk and Peter H. Yoon and Zehan Zhou and Trevor Weiss and Maris Kamalu and Ajit Chamraj and Kenneth J. Loi and Conner J. Langeberg and Ron S. Boger and Hunter Nisonoff and Hannah M. Karp and Lin-Xing Chen and Honglue Shi and Kamakshi Vohra and Jillian F. Banfield and Jamie H. D. Cate and Steven E. Jacobsen and Jennifer A. Doudna},
  year = {2026},
  journal = {Science},
  doi = {10.1126/science.aed6123},
  url = {https://doi.org/10.1126/science.aed6123}
}

RIS

TY  - JOUR
TI  - Structure and evolution-guided design of minimal RNA-guided nucleases
AU  - Petr Skopintsev
AU  - Isabel Esain-Garcia
AU  - Evan C. DeTurk
AU  - Peter H. Yoon
AU  - Zehan Zhou
AU  - Trevor Weiss
AU  - Maris Kamalu
AU  - Ajit Chamraj
AU  - Kenneth J. Loi
AU  - Conner J. Langeberg
AU  - Ron S. Boger
AU  - Hunter Nisonoff
AU  - Hannah M. Karp
AU  - Lin-Xing Chen
AU  - Honglue Shi
AU  - Kamakshi Vohra
AU  - Jillian F. Banfield
AU  - Jamie H. D. Cate
AU  - Steven E. Jacobsen
AU  - Jennifer A. Doudna
PY  - 2026
JO  - Science
DO  - 10.1126/science.aed6123
UR  - https://doi.org/10.1126/science.aed6123
ER  -

APA

Skopintsev, P., Esain-Garcia, I., DeTurk, E. C., Yoon, P. H., Zhou, Z., Weiss, T., Kamalu, M., Chamraj, A., Loi, K. J., Langeberg, C. J., Boger, R. S., Nisonoff, H., Karp, H. M., Chen, L., Shi, H., Vohra, K., Banfield, J. F., Cate, J. H. D., Jacobsen, S. E., & Doudna, J. A. (2026). Structure and evolution-guided design of minimal RNA-guided nucleases. Science. https://doi.org/10.1126/science.aed6123

Source records

crossref · retrieved 2026-09-24T22:42:44.749Z