Autoantibodies neutralizing type I IFNs are present in ~4% of uninfected individuals over 70 years old and account for ~20% of COVID-19 deaths.

Bastard P, Gervais A, Le Voyer T, Rosain J, Philippot Q, Manry J, Michailidis E, Hoffmann HH, Eto S, Garcia-Prat M, Bizien L, Parra-Martínez A, Yang R, Haljasmägi L, Migaud M, Särekannu K, Maslovskaja J, de Prost N, Tandjaoui-Lambiotte Y, Luyt CE, Amador-Borrero B, Gaudet A, Poissy J, Morel P, Richard P, Cognasse F, Troya J, Trouillet-Assant S, Belot A, Saker K, Garçon P, Rivière JG, Lagier JC, Gentile S, Rosen LB, Shaw E, Morio T, Tanaka J, Dalmau D, Tharaux PL, Sene D, Stepanian A, Megarbane B, Triantafyllia V, Fekkar A, Heath JR, Franco JL, Anaya JM, Solé-Violán J, Imberti L, Biondi A, Bonfanti P, Castagnoli R, Delmonte OM, Zhang Y, Snow AL, Holland SM, Biggs C, Moncada-Vélez M, Arias AA, Lorenzo L, Boucherit S, Coulibaly B, Anglicheau D, Planas AM, Haerynck F, Duvlis S, Nussbaum RL, Ozcelik T, Keles S, Bousfiha AA, El Bakkouri J, Ramirez-Santana C, Paul S, Pan-Hammarström Q, Hammarström L, Dupont A, Kurolap A, Metz CN, Aiuti A, Casari G, Lampasona V, Ciceri F, Barreiros LA, Dominguez-Garrido E, Vidigal M, Zatz M, van de Beek D, Sahanic S, Tancevski I, Stepanovskyy Y, Boyarchuk O, Nukui Y, Tsumura M, Vidaur L, Tangye SG, Burrel S, Duffy D, Quintana-Murci L, Klocperk A, Kann NY, Shcherbina A, Lau YL, Leung D, Coulongeat M, Marlet J, Koning R, Reyes LF, Chauvineau-Grenier A, Venet F, Monneret G, Nussenzweig MC, Arrestier R, Boudhabhay I, Baris-Feldman H, Hagin D, Wauters J, Meyts I, Dyer AH, Kennelly SP, Bourke NM, Halwani R, Sharif-Askari NS, Dorgham K, Sallette J, Sedkaoui SM, AlKhater S, Rigo-Bonnin R, Morandeira F, Roussel L, Vinh DC, Ostrowski SR, Condino-Neto A, Prando C, Bonradenko A, Spaan AN, Gilardin L, Fellay J, Lyonnet S, Bilguvar K, Lifton RP, Mane S, HGID Lab, COVID Clinicians, COVID-STORM Clinicians, NIAID Immune Response to COVID Group, NH-COVAIR Study Group, Danish CHGE, Danish Blood Donor Study, St. James's Hospital, SARS CoV2 Interest group, French COVID Cohort Study Group, Imagine COVID-Group, Milieu Intérieur Consortium, CoV-Contact Cohort, Amsterdam UMC Covid-19, Biobank Investigators, COVID Human Genetic Effort, CONSTANCES cohort, 3C-Dijon Study, Cerba Health-Care, Etablissement du Sang study group, Anderson MS, Boisson B, Béziat V, Zhang SY, Vandreakos E, Hermine O, Pujol A, Peterson P, Mogensen TH, Rowen L, Mond J, Debette S, de Lamballerie X, Duval X, Mentré F, Zins M, Soler-Palacin P, Colobran R, Gorochov G, Solanich X, Susen S, Martinez-Picado J, Raoult D, Vasse M, Gregersen PK, Piemonti L, Rodríguez-Gallego C, Notarangelo LD, Su HC, Kisand K, Okada S, Puel A, Jouanguy E, Rice CM, Tiberghien P, Zhang Q, Cobat A, Abel L, Casanova JL.

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DOI: 10.1126/sciimmunol.abl4340
Published: 2021-08-01
Container: Sci Immunol
Publisher: Not recorded
Open access: yes

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Cite this work

BibTeX

@article{allodium:10.1126/sciimmunol.abl4340,
  title = {Autoantibodies neutralizing type I IFNs are present in \&lt;b\&gt;\textasciitilde{}\&lt;/b\&gt;4\% of uninfected individuals over 70 years old and account for \&lt;b\&gt;\textasciitilde{}\&lt;/b\&gt;20\% of COVID-19 deaths.},
  author = {Bastard P and  Gervais A and  Le Voyer T and  Rosain J and  Philippot Q and  Manry J and  Michailidis E and  Hoffmann HH and  Eto S and  Garcia-Prat M and  Bizien L and  Parra-Martínez A and  Yang R and  Haljasmägi L and  Migaud M and  Särekannu K and  Maslovskaja J and  de Prost N and  Tandjaoui-Lambiotte Y and  Luyt CE and  Amador-Borrero B and  Gaudet A and  Poissy J and  Morel P and  Richard P and  Cognasse F and  Troya J and  Trouillet-Assant S and  Belot A and  Saker K and  Garçon P and  Rivière JG and  Lagier JC and  Gentile S and  Rosen LB and  Shaw E and  Morio T and  Tanaka J and  Dalmau D and  Tharaux PL and  Sene D and  Stepanian A and  Megarbane B and  Triantafyllia V and  Fekkar A and  Heath JR and  Franco JL and  Anaya JM and  Solé-Violán J and  Imberti L and  Biondi A and  Bonfanti P and  Castagnoli R and  Delmonte OM and  Zhang Y and  Snow AL and  Holland SM and  Biggs C and  Moncada-Vélez M and  Arias AA and  Lorenzo L and  Boucherit S and  Coulibaly B and  Anglicheau D and  Planas AM and  Haerynck F and  Duvlis S and  Nussbaum RL and  Ozcelik T and  Keles S and  Bousfiha AA and  El Bakkouri J and  Ramirez-Santana C and  Paul S and  Pan-Hammarström Q and  Hammarström L and  Dupont A and  Kurolap A and  Metz CN and  Aiuti A and  Casari G and  Lampasona V and  Ciceri F and  Barreiros LA and  Dominguez-Garrido E and  Vidigal M and  Zatz M and  van de Beek D and  Sahanic S and  Tancevski I and  Stepanovskyy Y and  Boyarchuk O and  Nukui Y and  Tsumura M and  Vidaur L and  Tangye SG and  Burrel S and  Duffy D and  Quintana-Murci L and  Klocperk A and  Kann NY and  Shcherbina A and  Lau YL and  Leung D and  Coulongeat M and  Marlet J and  Koning R and  Reyes LF and  Chauvineau-Grenier A and  Venet F and  Monneret G and  Nussenzweig MC and  Arrestier R and  Boudhabhay I and  Baris-Feldman H and  Hagin D and  Wauters J and  Meyts I and  Dyer AH and  Kennelly SP and  Bourke NM and  Halwani R and  Sharif-Askari NS and  Dorgham K and  Sallette J and  Sedkaoui SM and  AlKhater S and  Rigo-Bonnin R and  Morandeira F and  Roussel L and  Vinh DC and  Ostrowski SR and  Condino-Neto A and  Prando C and  Bonradenko A and  Spaan AN and  Gilardin L and  Fellay J and  Lyonnet S and  Bilguvar K and  Lifton RP and  Mane S and  HGID Lab and  COVID Clinicians and  COVID-STORM Clinicians and  NIAID Immune Response to COVID Group and  NH-COVAIR Study Group and  Danish CHGE and  Danish Blood Donor Study and  St. James's Hospital and  SARS CoV2 Interest group and  French COVID Cohort Study Group and  Imagine COVID-Group and  Milieu Intérieur Consortium and  CoV-Contact Cohort and  Amsterdam UMC Covid-19 and  Biobank Investigators and  COVID Human Genetic Effort and  CONSTANCES cohort and  3C-Dijon Study and  Cerba Health-Care and  Etablissement du Sang study group and  Anderson MS and  Boisson B and  Béziat V and  Zhang SY and  Vandreakos E and  Hermine O and  Pujol A and  Peterson P and  Mogensen TH and  Rowen L and  Mond J and  Debette S and  de Lamballerie X and  Duval X and  Mentré F and  Zins M and  Soler-Palacin P and  Colobran R and  Gorochov G and  Solanich X and  Susen S and  Martinez-Picado J and  Raoult D and  Vasse M and  Gregersen PK and  Piemonti L and  Rodríguez-Gallego C and  Notarangelo LD and  Su HC and  Kisand K and  Okada S and  Puel A and  Jouanguy E and  Rice CM and  Tiberghien P and  Zhang Q and  Cobat A and  Abel L and  Casanova JL.},
  year = {2021},
  journal = {Sci Immunol},
  doi = {10.1126/sciimmunol.abl4340},
  url = {https://doi.org/10.1126/sciimmunol.abl4340}
}

RIS

TY  - JOUR
TI  - Autoantibodies neutralizing type I IFNs are present in &lt;b&gt;~&lt;/b&gt;4% of uninfected individuals over 70 years old and account for &lt;b&gt;~&lt;/b&gt;20% of COVID-19 deaths.
AU  - Bastard P
AU  -  Gervais A
AU  -  Le Voyer T
AU  -  Rosain J
AU  -  Philippot Q
AU  -  Manry J
AU  -  Michailidis E
AU  -  Hoffmann HH
AU  -  Eto S
AU  -  Garcia-Prat M
AU  -  Bizien L
AU  -  Parra-Martínez A
AU  -  Yang R
AU  -  Haljasmägi L
AU  -  Migaud M
AU  -  Särekannu K
AU  -  Maslovskaja J
AU  -  de Prost N
AU  -  Tandjaoui-Lambiotte Y
AU  -  Luyt CE
AU  -  Amador-Borrero B
AU  -  Gaudet A
AU  -  Poissy J
AU  -  Morel P
AU  -  Richard P
AU  -  Cognasse F
AU  -  Troya J
AU  -  Trouillet-Assant S
AU  -  Belot A
AU  -  Saker K
AU  -  Garçon P
AU  -  Rivière JG
AU  -  Lagier JC
AU  -  Gentile S
AU  -  Rosen LB
AU  -  Shaw E
AU  -  Morio T
AU  -  Tanaka J
AU  -  Dalmau D
AU  -  Tharaux PL
AU  -  Sene D
AU  -  Stepanian A
AU  -  Megarbane B
AU  -  Triantafyllia V
AU  -  Fekkar A
AU  -  Heath JR
AU  -  Franco JL
AU  -  Anaya JM
AU  -  Solé-Violán J
AU  -  Imberti L
AU  -  Biondi A
AU  -  Bonfanti P
AU  -  Castagnoli R
AU  -  Delmonte OM
AU  -  Zhang Y
AU  -  Snow AL
AU  -  Holland SM
AU  -  Biggs C
AU  -  Moncada-Vélez M
AU  -  Arias AA
AU  -  Lorenzo L
AU  -  Boucherit S
AU  -  Coulibaly B
AU  -  Anglicheau D
AU  -  Planas AM
AU  -  Haerynck F
AU  -  Duvlis S
AU  -  Nussbaum RL
AU  -  Ozcelik T
AU  -  Keles S
AU  -  Bousfiha AA
AU  -  El Bakkouri J
AU  -  Ramirez-Santana C
AU  -  Paul S
AU  -  Pan-Hammarström Q
AU  -  Hammarström L
AU  -  Dupont A
AU  -  Kurolap A
AU  -  Metz CN
AU  -  Aiuti A
AU  -  Casari G
AU  -  Lampasona V
AU  -  Ciceri F
AU  -  Barreiros LA
AU  -  Dominguez-Garrido E
AU  -  Vidigal M
AU  -  Zatz M
AU  -  van de Beek D
AU  -  Sahanic S
AU  -  Tancevski I
AU  -  Stepanovskyy Y
AU  -  Boyarchuk O
AU  -  Nukui Y
AU  -  Tsumura M
AU  -  Vidaur L
AU  -  Tangye SG
AU  -  Burrel S
AU  -  Duffy D
AU  -  Quintana-Murci L
AU  -  Klocperk A
AU  -  Kann NY
AU  -  Shcherbina A
AU  -  Lau YL
AU  -  Leung D
AU  -  Coulongeat M
AU  -  Marlet J
AU  -  Koning R
AU  -  Reyes LF
AU  -  Chauvineau-Grenier A
AU  -  Venet F
AU  -  Monneret G
AU  -  Nussenzweig MC
AU  -  Arrestier R
AU  -  Boudhabhay I
AU  -  Baris-Feldman H
AU  -  Hagin D
AU  -  Wauters J
AU  -  Meyts I
AU  -  Dyer AH
AU  -  Kennelly SP
AU  -  Bourke NM
AU  -  Halwani R
AU  -  Sharif-Askari NS
AU  -  Dorgham K
AU  -  Sallette J
AU  -  Sedkaoui SM
AU  -  AlKhater S
AU  -  Rigo-Bonnin R
AU  -  Morandeira F
AU  -  Roussel L
AU  -  Vinh DC
AU  -  Ostrowski SR
AU  -  Condino-Neto A
AU  -  Prando C
AU  -  Bonradenko A
AU  -  Spaan AN
AU  -  Gilardin L
AU  -  Fellay J
AU  -  Lyonnet S
AU  -  Bilguvar K
AU  -  Lifton RP
AU  -  Mane S
AU  -  HGID Lab
AU  -  COVID Clinicians
AU  -  COVID-STORM Clinicians
AU  -  NIAID Immune Response to COVID Group
AU  -  NH-COVAIR Study Group
AU  -  Danish CHGE
AU  -  Danish Blood Donor Study
AU  -  St. James's Hospital
AU  -  SARS CoV2 Interest group
AU  -  French COVID Cohort Study Group
AU  -  Imagine COVID-Group
AU  -  Milieu Intérieur Consortium
AU  -  CoV-Contact Cohort
AU  -  Amsterdam UMC Covid-19
AU  -  Biobank Investigators
AU  -  COVID Human Genetic Effort
AU  -  CONSTANCES cohort
AU  -  3C-Dijon Study
AU  -  Cerba Health-Care
AU  -  Etablissement du Sang study group
AU  -  Anderson MS
AU  -  Boisson B
AU  -  Béziat V
AU  -  Zhang SY
AU  -  Vandreakos E
AU  -  Hermine O
AU  -  Pujol A
AU  -  Peterson P
AU  -  Mogensen TH
AU  -  Rowen L
AU  -  Mond J
AU  -  Debette S
AU  -  de Lamballerie X
AU  -  Duval X
AU  -  Mentré F
AU  -  Zins M
AU  -  Soler-Palacin P
AU  -  Colobran R
AU  -  Gorochov G
AU  -  Solanich X
AU  -  Susen S
AU  -  Martinez-Picado J
AU  -  Raoult D
AU  -  Vasse M
AU  -  Gregersen PK
AU  -  Piemonti L
AU  -  Rodríguez-Gallego C
AU  -  Notarangelo LD
AU  -  Su HC
AU  -  Kisand K
AU  -  Okada S
AU  -  Puel A
AU  -  Jouanguy E
AU  -  Rice CM
AU  -  Tiberghien P
AU  -  Zhang Q
AU  -  Cobat A
AU  -  Abel L
AU  -  Casanova JL.
PY  - 2021
JO  - Sci Immunol
DO  - 10.1126/sciimmunol.abl4340
UR  - https://doi.org/10.1126/sciimmunol.abl4340
ER  -

APA

P, B., A, G., T, L. V., J, R., Q, P., J, M., E, M., HH, H., S, E., M, G., L, B., A, P., R, Y., L, H., M, M., K, S., J, M., N, D. P., Y, T., CE, L., B, A., A, G., J, P., P, M., P, R., F, C., J, T., S, T., A, B., K, S., P, G., JG, R., JC, L., S, G., LB, R., E, S., T, M., J, T., D, D., PL, T., D, S., A, S., B, M., V, T., A, F., JR, H., JL, F., JM, A., J, S., L, I., A, B., P, B., R, C., OM, D., Y, Z., AL, S., SM, H., C, B., M, M., AA, A., L, L., S, B., B, C., D, A., AM, P., F, H., S, D., RL, N., T, O., S, K., AA, B., J, E. B., C, R., S, P., Q, P., L, H., A, D., A, K., CN, M., A, A., G, C., V, L., F, C., LA, B., E, D., M, V., M, Z., D, V. D. B., S, S., I, T., Y, S., O, B., Y, N., M, T., L, V., SG, T., S, B., D, D., L, Q., A, K., NY, K., A, S., YL, L., D, L., M, C., J, M., R, K., LF, R., A, C., F, V., G, M., MC, N., R, A., I, B., H, B., D, H., J, W., I, M., AH, D., SP, K., NM, B., R, H., NS, S., K, D., J, S., SM, S., S, A., R, R., F, M., L, R., DC, V., SR, O., A, C., C, P., A, B., AN, S., L, G., J, F., S, L., K, B., RP, L., S, M., Lab, H., Clinicians, C., Clinicians, C., Group, N. I. R. T. C., Group, N. S., CHGE, D., Study, D. B. D., Hospital, S. J., group, S. C. I., Group, F. C. C. S., COVID-Group, I., Consortium, M. I., Cohort, C., Covid-19, A. U., Investigators, B., Effort, C. H. G., cohort, C., Study, 3., Health-Care, C., group, E. D. S. S., MS, A., B, B., V, B., SY, Z., E, V., O, H., A, P., P, P., TH, M., L, R., J, M., S, D., X, D. L., X, D., F, M., M, Z., P, S., R, C., G, G., X, S., S, S., J, M., D, R., M, V., PK, G., L, P., C, R., LD, N., HC, S., K, K., S, O., A, P., E, J., CM, R., P, T., Q, Z., A, C., L, A., & JL., C. (2021). Autoantibodies neutralizing type I IFNs are present in ~4% of uninfected individuals over 70 years old and account for ~20% of COVID-19 deaths.. Sci Immunol. https://doi.org/10.1126/sciimmunol.abl4340

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europe-pmc · retrieved 2026-09-26T12:42:53.676Z
hal · retrieved 2026-09-26T12:42:53.690Z

Autoantibodies neutralizing type I IFNs are present in &lt;b&gt;~&lt;/b&gt;4% of uninfected individuals over 70 years old and account for &lt;b&gt;~&lt;/b&gt;20% of COVID-19 deaths.

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Autoantibodies neutralizing type I IFNs are present in <b>~</b>4% of uninfected individuals over 70 years old and account for <b>~</b>20% of COVID-19 deaths.