Platelet-derived serotonin drives age-related lung pathology in SARS-CoV-2 infection

Davide Marotta, Chiara Perucchini, Marta Grillo, Valeria Fumagalli, Pietro Di Lucia, Jordan Rixon, Micol Ravà, Leonardo Giustini, Chiara Malpighi, Giulia D’Uonnolo, Mariangela Scavone, Violette Mouro, Caitlin Abbott, Natalia Stachura-Chyla, Francesco Andreata, Erica Scalambrino, Marigrazia Clerici, Lorena Donnici, Marika Longo Minnolo, Donato Inverso, Raffaele De Francesco, Mauro Gaya, Zaverio M. Ruggeri, Armando Tripodi, Gian Marco Podda, Luca G. Guidotti, Matteo Iannacone, Marco De Giovanni

Open source

DOI: 10.1126/sciimmunol.aec9853
Published: 2026-08-28
Container: Science Immunology
Publisher: American Association for the Advancement of Science (AAAS)
Open access: unknown

Credibility signals

uncertain Score 64/100 under policy 1.0.0. This is a metadata assessment, not a judgment of the paper's conclusions.

Show all credibility signals

supportingDOI registered: A matching record was returned by Crossref. Source: Crossref; license: CC0 metadata
supportingDOI resolves: A matching record was returned by Crossref. Source: Crossref; license: CC0 metadata
not scoredDirectory of Open Access Journals: No matching DOAJ record was present in this response. No allow-list match; this is not evidence of low credibility. Source: DOAJ; license: CC0
not scoredMEDLINE indexed: Not checked or no result supplied; no credibility inference made. Source: No authority result supplied; license: Unknown
not scoredOpenAlex core source: Not checked or no result supplied; no credibility inference made. Source: No authority result supplied; license: Unknown
not scoredKnown publisher allow-list: Not checked or no result supplied; no credibility inference made. Source: No authority result supplied; license: Unknown
not scoredROR affiliation: Not checked or no result supplied; no credibility inference made. Source: No authority result supplied; license: Unknown
not scoredRetraction Watch retraction: No retraction notice matched this DOI in the deployed snapshot. No matching event found; coverage may be incomplete. Source: Retraction Watch; license: CC BY 4.0
not scoredRetraction Watch expression of concern: No expression of concern notice matched this DOI in the deployed snapshot. No matching event found; coverage may be incomplete. Source: Retraction Watch; license: CC BY 4.0
not scoredRetraction Watch correction: No correction notice matched this DOI in the deployed snapshot. No matching event found; coverage may be incomplete. Source: Retraction Watch; license: CC BY 4.0
not scoredRetraction Watch reinstatement: No reinstatement notice matched this DOI in the deployed snapshot. No matching event found; coverage may be incomplete. Source: Retraction Watch; license: CC BY 4.0
not scoredOpen access status: Not checked or no result supplied; no credibility inference made. Source: No authority result supplied; license: Unknown
not scoredPublication license: Not checked or no result supplied; no credibility inference made. Source: No authority result supplied; license: Unknown
not scoredPublication version: A publication version was supplied but is not scored. Source: Normalized work metadata; license: Caller-provided; provenance license not supplied to scorer
supportingMetadata completeness: All 6 scored descriptive metadata groups are present. Source: Normalized work metadata; license: Caller-provided; provenance license not supplied to scorer

Cite this work

BibTeX

@article{allodium:10.1126/sciimmunol.aec9853,
  title = {Platelet-derived serotonin drives age-related lung pathology in SARS-CoV-2 infection},
  author = {Davide Marotta and Chiara Perucchini and Marta Grillo and Valeria Fumagalli and Pietro Di Lucia and Jordan Rixon and Micol Ravà and Leonardo Giustini and Chiara Malpighi and Giulia D’Uonnolo and Mariangela Scavone and Violette Mouro and Caitlin Abbott and Natalia Stachura-Chyla and Francesco Andreata and Erica Scalambrino and Marigrazia Clerici and Lorena Donnici and Marika Longo Minnolo and Donato Inverso and Raffaele De Francesco and Mauro Gaya and Zaverio M. Ruggeri and Armando Tripodi and Gian Marco Podda and Luca G. Guidotti and Matteo Iannacone and Marco De Giovanni},
  year = {2026},
  journal = {Science Immunology},
  doi = {10.1126/sciimmunol.aec9853},
  url = {https://doi.org/10.1126/sciimmunol.aec9853}
}

RIS

TY  - JOUR
TI  - Platelet-derived serotonin drives age-related lung pathology in SARS-CoV-2 infection
AU  - Davide Marotta
AU  - Chiara Perucchini
AU  - Marta Grillo
AU  - Valeria Fumagalli
AU  - Pietro Di Lucia
AU  - Jordan Rixon
AU  - Micol Ravà
AU  - Leonardo Giustini
AU  - Chiara Malpighi
AU  - Giulia D’Uonnolo
AU  - Mariangela Scavone
AU  - Violette Mouro
AU  - Caitlin Abbott
AU  - Natalia Stachura-Chyla
AU  - Francesco Andreata
AU  - Erica Scalambrino
AU  - Marigrazia Clerici
AU  - Lorena Donnici
AU  - Marika Longo Minnolo
AU  - Donato Inverso
AU  - Raffaele De Francesco
AU  - Mauro Gaya
AU  - Zaverio M. Ruggeri
AU  - Armando Tripodi
AU  - Gian Marco Podda
AU  - Luca G. Guidotti
AU  - Matteo Iannacone
AU  - Marco De Giovanni
PY  - 2026
JO  - Science Immunology
DO  - 10.1126/sciimmunol.aec9853
UR  - https://doi.org/10.1126/sciimmunol.aec9853
ER  -

APA

Marotta, D., Perucchini, C., Grillo, M., Fumagalli, V., Lucia, P. D., Rixon, J., Ravà, M., Giustini, L., Malpighi, C., D’Uonnolo, G., Scavone, M., Mouro, V., Abbott, C., Stachura-Chyla, N., Andreata, F., Scalambrino, E., Clerici, M., Donnici, L., Minnolo, M. L., Inverso, D., Francesco, R. D., Gaya, M., Ruggeri, Z. M., Tripodi, A., Podda, G. M., Guidotti, L. G., Iannacone, M., & Giovanni, M. D. (2026). Platelet-derived serotonin drives age-related lung pathology in SARS-CoV-2 infection. Science Immunology. https://doi.org/10.1126/sciimmunol.aec9853

Source records

crossref · retrieved 2026-09-26T10:25:58.030Z