Genome-wide study of DNA methylation shows alterations in metabolic, inflammatory, and cholesterol pathways in ALS

Paul J. Hop, Ramona A.J. Zwamborn, Eilis Hannon, Gemma L. Shireby, Marta F. Nabais, Emma M. Walker, Wouter van Rheenen, Joke J.F.A. van Vugt, Annelot M. Dekker, Henk-Jan Westeneng, Gijs H.P. Tazelaar, Kristel R. van Eijk, Matthieu Moisse, Denis Baird, Ahmad Al Khleifat, Alfredo Iacoangeli, Nicola Ticozzi, Antonia Ratti, Jonathan Cooper-Knock, Karen E. Morrison, Pamela J. Shaw, A. Nazli Basak, Adriano Chiò, Andrea Calvo, Cristina Moglia, Antonio Canosa, Maura Brunetti, Maurizio Grassano, Marc Gotkine, Yossef Lerner, Michal Zabari, Patrick Vourc’h, Philippe Corcia, Philippe Couratier, Jesus S. Mora Pardina, Teresa Salas, Patrick Dion, Jay P. Ross, Robert D. Henderson, Susan Mathers, Pamela A. McCombe, Merrilee Needham, Garth Nicholson, Dominic B. Rowe, Roger Pamphlett, Karen A. Mather, Perminder S. Sachdev, Sarah Furlong, Fleur C. Garton, Anjali K. Henders, Tian Lin, Shyuan T. Ngo, Frederik J. Steyn, Leanne Wallace, Kelly L. Williams, Unknown, Unknown, Miguel Mitne Neto, Ruben J. Cauchi, Ian P. Blair, Matthew C. Kiernan, Vivian Drory, Monica Povedano, Mamede de Carvalho, Susana Pinto, Markus Weber, Guy A. Rouleau, Vincenzo Silani, John E. Landers, Christopher E. Shaw, Peter M. Andersen, Allan F. McRae, Michael A. van Es, R. Jeroen Pasterkamp, Naomi R. Wray, Russell L. McLaughlin, Orla Hardiman, Kevin P. Kenna, Ellen Tsai, Heiko Runz, Ammar Al-Chalabi, Leonard H. van den Berg, Philip Van Damme, Jonathan Mill, Jan H. Veldink, Bastiaan T. Heijmans, Peter A.C. t Hoen, Joyce van Meurs, Rick Jansen, Lude Franke, Dorret I. Boomsma, Rene Pool, Jenny van Dongen, Joukje J. Hottenga, Marleen M.J. van Greevenbroek, Coen D.A. Stehouwer, Carla J.H. van der Kallen, Casper G. Schalkwijk, Cisca Wijmenga, Lude Franke, Sasha Zhernakova, Ettje F. Tigchelaar, P. Eline Slagboom, Marian Beekman, Joris Deelen, Diana van Heemst, Jan H. Veldink, Leonard H. van den Berg, Cornelia M. van Duijn, Bert A. Hofman, Aaron Isaacs, Andre G. Uitterlinden, Joyce van Meurs, P. Mila Jhamai, Michael Verbiest, H. Eka D. Suchiman, Marijn Verkerk, Ruud van der Breggen, Jeroen van Rooij, Nico Lakenberg, Hailiang Mei, Maarten van Iterson, Michiel van Galen, Jan Bot, Dasha V. Zhernakova, Rick Jansen, Peter van ‘t Hof, Patrick Deelen, Irene Nooren, Peter A.C. t Hoen, Bastiaan T. Heijmans, Matthijs Moed, Lude Franke, Martijn Vermaat, Dasha V. Zhernakova, Rene Luijk, Marc Jan Bonder, Maarten van Iterson, Patrick Deelen, Freerk van Dijk, Michiel van Galen, Wibowo Arindrarto, Szymon M. Kielbasa, Morris A. Swertz, Erik W. van Zwet, Rick Jansen, Peter A.C. t Hoen, Bastiaan T. Heijmans, Ammar Al-Chalabi, Naomi R. Wray, Gilbert Bensimon, Orla Hardiman, Adriano Chio, Jan H. Veldink, George Davey Smith, Jonathan Mill

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DOI: 10.1126/scitranslmed.abj0264
Published: 2022-02-23
Container: Science Translational Medicine
Publisher: American Association for the Advancement of Science (AAAS)
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BibTeX

@article{allodium:10.1126/scitranslmed.abj0264,
title = {Genome-wide study of DNA methylation shows alterations in metabolic, inflammatory, and cholesterol pathways in ALS},
author = {Paul J. Hop and Ramona A.J. Zwamborn and Eilis Hannon and Gemma L. Shireby and Marta F. Nabais and Emma M. Walker and Wouter van Rheenen and Joke J.F.A. van Vugt and Annelot M. Dekker and Henk-Jan Westeneng and Gijs H.P. Tazelaar and Kristel R. van Eijk and Matthieu Moisse and Denis Baird and Ahmad Al Khleifat and Alfredo Iacoangeli and Nicola Ticozzi and Antonia Ratti and Jonathan Cooper-Knock and Karen E. Morrison and Pamela J. Shaw and A. Nazli Basak and Adriano Chiò and Andrea Calvo and Cristina Moglia and Antonio Canosa and Maura Brunetti and Maurizio Grassano and Marc Gotkine and Yossef Lerner and Michal Zabari and Patrick Vourc’h and Philippe Corcia and Philippe Couratier and Jesus S. Mora Pardina and Teresa Salas and Patrick Dion and Jay P. Ross and Robert D. Henderson and Susan Mathers and Pamela A. McCombe and Merrilee Needham and Garth Nicholson and Dominic B. Rowe and Roger Pamphlett and Karen A. Mather and Perminder S. Sachdev and Sarah Furlong and Fleur C. Garton and Anjali K. Henders and Tian Lin and Shyuan T. Ngo and Frederik J. Steyn and Leanne Wallace and Kelly L. Williams and Unknown and Unknown and Miguel Mitne Neto and Ruben J. Cauchi and Ian P. Blair and Matthew C. Kiernan and Vivian Drory and Monica Povedano and Mamede de Carvalho and Susana Pinto and Markus Weber and Guy A. Rouleau and Vincenzo Silani and John E. Landers and Christopher E. Shaw and Peter M. Andersen and Allan F. McRae and Michael A. van Es and R. Jeroen Pasterkamp and Naomi R. Wray and Russell L. McLaughlin and Orla Hardiman and Kevin P. Kenna and Ellen Tsai and Heiko Runz and Ammar Al-Chalabi and Leonard H. van den Berg and Philip Van Damme and Jonathan Mill and Jan H. Veldink and Bastiaan T. Heijmans and Peter A.C. t Hoen and Joyce van Meurs and Rick Jansen and Lude Franke and Dorret I. Boomsma and Rene Pool and Jenny van Dongen and Joukje J. Hottenga and Marleen M.J. van Greevenbroek and Coen D.A. Stehouwer and Carla J.H. van der Kallen and Casper G. Schalkwijk and Cisca Wijmenga and Lude Franke and Sasha Zhernakova and Ettje F. Tigchelaar and P. Eline Slagboom and Marian Beekman and Joris Deelen and Diana van Heemst and Jan H. Veldink and Leonard H. van den Berg and Cornelia M. van Duijn and Bert A. Hofman and Aaron Isaacs and Andre G. Uitterlinden and Joyce van Meurs and P. Mila Jhamai and Michael Verbiest and H. Eka D. Suchiman and Marijn Verkerk and Ruud van der Breggen and Jeroen van Rooij and Nico Lakenberg and Hailiang Mei and Maarten van Iterson and Michiel van Galen and Jan Bot and Dasha V. Zhernakova and Rick Jansen and Peter van ‘t Hof and Patrick Deelen and Irene Nooren and Peter A.C. t Hoen and Bastiaan T. Heijmans and Matthijs Moed and Lude Franke and Martijn Vermaat and Dasha V. Zhernakova and Rene Luijk and Marc Jan Bonder and Maarten van Iterson and Patrick Deelen and Freerk van Dijk and Michiel van Galen and Wibowo Arindrarto and Szymon M. Kielbasa and Morris A. Swertz and Erik W. van Zwet and Rick Jansen and Peter A.C. t Hoen and Bastiaan T. Heijmans and Ammar Al-Chalabi and Naomi R. Wray and Gilbert Bensimon and Orla Hardiman and Adriano Chio and Jan H. Veldink and George Davey Smith and Jonathan Mill},
year = {2022},
journal = {Science Translational Medicine},
doi = {10.1126/scitranslmed.abj0264},
url = {https://doi.org/10.1126/scitranslmed.abj0264}
}

RIS

TY  - JOUR
TI  - Genome-wide study of DNA methylation shows alterations in metabolic, inflammatory, and cholesterol pathways in ALS
AU  - Paul J. Hop
AU  - Ramona A.J. Zwamborn
AU  - Eilis Hannon
AU  - Gemma L. Shireby
AU  - Marta F. Nabais
AU  - Emma M. Walker
AU  - Wouter van Rheenen
AU  - Joke J.F.A. van Vugt
AU  - Annelot M. Dekker
AU  - Henk-Jan Westeneng
AU  - Gijs H.P. Tazelaar
AU  - Kristel R. van Eijk
AU  - Matthieu Moisse
AU  - Denis Baird
AU  - Ahmad Al Khleifat
AU  - Alfredo Iacoangeli
AU  - Nicola Ticozzi
AU  - Antonia Ratti
AU  - Jonathan Cooper-Knock
AU  - Karen E. Morrison
AU  - Pamela J. Shaw
AU  - A. Nazli Basak
AU  - Adriano Chiò
AU  - Andrea Calvo
AU  - Cristina Moglia
AU  - Antonio Canosa
AU  - Maura Brunetti
AU  - Maurizio Grassano
AU  - Marc Gotkine
AU  - Yossef Lerner
AU  - Michal Zabari
AU  - Patrick Vourc’h
AU  - Philippe Corcia
AU  - Philippe Couratier
AU  - Jesus S. Mora Pardina
AU  - Teresa Salas
AU  - Patrick Dion
AU  - Jay P. Ross
AU  - Robert D. Henderson
AU  - Susan Mathers
AU  - Pamela A. McCombe
AU  - Merrilee Needham
AU  - Garth Nicholson
AU  - Dominic B. Rowe
AU  - Roger Pamphlett
AU  - Karen A. Mather
AU  - Perminder S. Sachdev
AU  - Sarah Furlong
AU  - Fleur C. Garton
AU  - Anjali K. Henders
AU  - Tian Lin
AU  - Shyuan T. Ngo
AU  - Frederik J. Steyn
AU  - Leanne Wallace
AU  - Kelly L. Williams
AU  - Unknown
AU  - Unknown
AU  - Miguel Mitne Neto
AU  - Ruben J. Cauchi
AU  - Ian P. Blair
AU  - Matthew C. Kiernan
AU  - Vivian Drory
AU  - Monica Povedano
AU  - Mamede de Carvalho
AU  - Susana Pinto
AU  - Markus Weber
AU  - Guy A. Rouleau
AU  - Vincenzo Silani
AU  - John E. Landers
AU  - Christopher E. Shaw
AU  - Peter M. Andersen
AU  - Allan F. McRae
AU  - Michael A. van Es
AU  - R. Jeroen Pasterkamp
AU  - Naomi R. Wray
AU  - Russell L. McLaughlin
AU  - Orla Hardiman
AU  - Kevin P. Kenna
AU  - Ellen Tsai
AU  - Heiko Runz
AU  - Ammar Al-Chalabi
AU  - Leonard H. van den Berg
AU  - Philip Van Damme
AU  - Jonathan Mill
AU  - Jan H. Veldink
AU  - Bastiaan T. Heijmans
AU  - Peter A.C. t Hoen
AU  - Joyce van Meurs
AU  - Rick Jansen
AU  - Lude Franke
AU  - Dorret I. Boomsma
AU  - Rene Pool
AU  - Jenny van Dongen
AU  - Joukje J. Hottenga
AU  - Marleen M.J. van Greevenbroek
AU  - Coen D.A. Stehouwer
AU  - Carla J.H. van der Kallen
AU  - Casper G. Schalkwijk
AU  - Cisca Wijmenga
AU  - Lude Franke
AU  - Sasha Zhernakova
AU  - Ettje F. Tigchelaar
AU  - P. Eline Slagboom
AU  - Marian Beekman
AU  - Joris Deelen
AU  - Diana van Heemst
AU  - Jan H. Veldink
AU  - Leonard H. van den Berg
AU  - Cornelia M. van Duijn
AU  - Bert A. Hofman
AU  - Aaron Isaacs
AU  - Andre G. Uitterlinden
AU  - Joyce van Meurs
AU  - P. Mila Jhamai
AU  - Michael Verbiest
AU  - H. Eka D. Suchiman
AU  - Marijn Verkerk
AU  - Ruud van der Breggen
AU  - Jeroen van Rooij
AU  - Nico Lakenberg
AU  - Hailiang Mei
AU  - Maarten van Iterson
AU  - Michiel van Galen
AU  - Jan Bot
AU  - Dasha V. Zhernakova
AU  - Rick Jansen
AU  - Peter van ‘t Hof
AU  - Patrick Deelen
AU  - Irene Nooren
AU  - Peter A.C. t Hoen
AU  - Bastiaan T. Heijmans
AU  - Matthijs Moed
AU  - Lude Franke
AU  - Martijn Vermaat
AU  - Dasha V. Zhernakova
AU  - Rene Luijk
AU  - Marc Jan Bonder
AU  - Maarten van Iterson
AU  - Patrick Deelen
AU  - Freerk van Dijk
AU  - Michiel van Galen
AU  - Wibowo Arindrarto
AU  - Szymon M. Kielbasa
AU  - Morris A. Swertz
AU  - Erik W. van Zwet
AU  - Rick Jansen
AU  - Peter A.C. t Hoen
AU  - Bastiaan T. Heijmans
AU  - Ammar Al-Chalabi
AU  - Naomi R. Wray
AU  - Gilbert Bensimon
AU  - Orla Hardiman
AU  - Adriano Chio
AU  - Jan H. Veldink
AU  - George Davey Smith
AU  - Jonathan Mill
PY  - 2022
JO  - Science Translational Medicine
DO  - 10.1126/scitranslmed.abj0264
UR  - https://doi.org/10.1126/scitranslmed.abj0264
ER  -

APA

Hop, P. J., Zwamborn, R. A., Hannon, E., Shireby, G. L., Nabais, M. F., Walker, E. M., Rheenen, W. V., Vugt, J. J. V., Dekker, A. M., Westeneng, H., Tazelaar, G. H., Eijk, K. R. V., Moisse, M., Baird, D., Khleifat, A. A., Iacoangeli, A., Ticozzi, N., Ratti, A., Cooper-Knock, J., Morrison, K. E., Shaw, P. J., Basak, A. N., Chiò, A., Calvo, A., Moglia, C., Canosa, A., Brunetti, M., Grassano, M., Gotkine, M., Lerner, Y., Zabari, M., Vourc’h, P., Corcia, P., Couratier, P., Pardina, J. S. M., Salas, T., Dion, P., Ross, J. P., Henderson, R. D., Mathers, S., McCombe, P. A., Needham, M., Nicholson, G., Rowe, D. B., Pamphlett, R., Mather, K. A., Sachdev, P. S., Furlong, S., Garton, F. C., Henders, A. K., Lin, T., Ngo, S. T., Steyn, F. J., Wallace, L., Williams, K. L., Unknown, Unknown, Neto, M. M., Cauchi, R. J., Blair, I. P., Kiernan, M. C., Drory, V., Povedano, M., Carvalho, M. D., Pinto, S., Weber, M., Rouleau, G. A., Silani, V., Landers, J. E., Shaw, C. E., Andersen, P. M., McRae, A. F., Es, M. A. V., Pasterkamp, R. J., Wray, N. R., McLaughlin, R. L., Hardiman, O., Kenna, K. P., Tsai, E., Runz, H., Al-Chalabi, A., Berg, L. H. V. D., Damme, P. V., Mill, J., Veldink, J. H., Heijmans, B. T., Hoen, P. A. T., Meurs, J. V., Jansen, R., Franke, L., Boomsma, D. I., Pool, R., Dongen, J. V., Hottenga, J. J., Greevenbroek, M. M. V., Stehouwer, C. D., Kallen, C. J. V. D., Schalkwijk, C. G., Wijmenga, C., Franke, L., Zhernakova, S., Tigchelaar, E. F., Slagboom, P. E., Beekman, M., Deelen, J., Heemst, D. V., Veldink, J. H., Berg, L. H. V. D., Duijn, C. M. V., Hofman, B. A., Isaacs, A., Uitterlinden, A. G., Meurs, J. V., Jhamai, P. M., Verbiest, M., Suchiman, H. E. D., Verkerk, M., Breggen, R. V. D., Rooij, J. V., Lakenberg, N., Mei, H., Iterson, M. V., Galen, M. V., Bot, J., Zhernakova, D. V., Jansen, R., Hof, P. V. ‘., Deelen, P., Nooren, I., Hoen, P. A. T., Heijmans, B. T., Moed, M., Franke, L., Vermaat, M., Zhernakova, D. V., Luijk, R., Bonder, M. J., Iterson, M. V., Deelen, P., Dijk, F. V., Galen, M. V., Arindrarto, W., Kielbasa, S. M., Swertz, M. A., Zwet, E. W. V., Jansen, R., Hoen, P. A. T., Heijmans, B. T., Al-Chalabi, A., Wray, N. R., Bensimon, G., Hardiman, O., Chio, A., Veldink, J. H., Smith, G. D., & Mill, J. (2022). Genome-wide study of DNA methylation shows alterations in metabolic, inflammatory, and cholesterol pathways in ALS. Science Translational Medicine. https://doi.org/10.1126/scitranslmed.abj0264

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