Multivalent designed proteins neutralize SARS-CoV-2 variants of concern and confer protection against infection in mice

Andrew C. Hunt, James Brett Case, Young-Jun Park, Longxing Cao, Kejia Wu, Alexandra C. Walls, Zhuoming Liu, John E. Bowen, Hsien-Wei Yeh, Shally Saini, Louisa Helms, Yan Ting Zhao, Tien-Ying Hsiang, Tyler N. Starr, Inna Goreshnik, Lisa Kozodoy, Lauren Carter, Rashmi Ravichandran, Lydia B. Green, Wadim L. Matochko, Christy A. Thomson, Bastian Vögeli, Antje Krüger, Laura A. VanBlargan, Rita E. Chen, Baoling Ying, Adam L. Bailey, Natasha M. Kafai, Scott E. Boyken, Ajasja Ljubetič, Natasha Edman, George Ueda, Cameron M. Chow, Max Johnson, Amin Addetia, Mary-Jane Navarro, Nuttada Panpradist, Michael Gale, Benjamin S. Freedman, Jesse D. Bloom, Hannele Ruohola-Baker, Sean P. J. Whelan, Lance Stewart, Michael S. Diamond, David Veesler, Michael C. Jewett, David Baker

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DOI: 10.1126/scitranslmed.abn1252
Published: 2022-05-25
Container: Science Translational Medicine
Publisher: American Association for the Advancement of Science (AAAS)
Open access: unknown

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Cite this work

BibTeX

@article{allodium:10.1126/scitranslmed.abn1252,
  title = {Multivalent designed proteins neutralize SARS-CoV-2 variants of concern and confer protection against infection in mice},
  author = {Andrew C. Hunt and James Brett Case and Young-Jun Park and Longxing Cao and Kejia Wu and Alexandra C. Walls and Zhuoming Liu and John E. Bowen and Hsien-Wei Yeh and Shally Saini and Louisa Helms and Yan Ting Zhao and Tien-Ying Hsiang and Tyler N. Starr and Inna Goreshnik and Lisa Kozodoy and Lauren Carter and Rashmi Ravichandran and Lydia B. Green and Wadim L. Matochko and Christy A. Thomson and Bastian Vögeli and Antje Krüger and Laura A. VanBlargan and Rita E. Chen and Baoling Ying and Adam L. Bailey and Natasha M. Kafai and Scott E. Boyken and Ajasja Ljubetič and Natasha Edman and George Ueda and Cameron M. Chow and Max Johnson and Amin Addetia and Mary-Jane Navarro and Nuttada Panpradist and Michael Gale and Benjamin S. Freedman and Jesse D. Bloom and Hannele Ruohola-Baker and Sean P. J. Whelan and Lance Stewart and Michael S. Diamond and David Veesler and Michael C. Jewett and David Baker},
  year = {2022},
  journal = {Science Translational Medicine},
  doi = {10.1126/scitranslmed.abn1252},
  url = {https://doi.org/10.1126/scitranslmed.abn1252}
}

RIS

TY  - JOUR
TI  - Multivalent designed proteins neutralize SARS-CoV-2 variants of concern and confer protection against infection in mice
AU  - Andrew C. Hunt
AU  - James Brett Case
AU  - Young-Jun Park
AU  - Longxing Cao
AU  - Kejia Wu
AU  - Alexandra C. Walls
AU  - Zhuoming Liu
AU  - John E. Bowen
AU  - Hsien-Wei Yeh
AU  - Shally Saini
AU  - Louisa Helms
AU  - Yan Ting Zhao
AU  - Tien-Ying Hsiang
AU  - Tyler N. Starr
AU  - Inna Goreshnik
AU  - Lisa Kozodoy
AU  - Lauren Carter
AU  - Rashmi Ravichandran
AU  - Lydia B. Green
AU  - Wadim L. Matochko
AU  - Christy A. Thomson
AU  - Bastian Vögeli
AU  - Antje Krüger
AU  - Laura A. VanBlargan
AU  - Rita E. Chen
AU  - Baoling Ying
AU  - Adam L. Bailey
AU  - Natasha M. Kafai
AU  - Scott E. Boyken
AU  - Ajasja Ljubetič
AU  - Natasha Edman
AU  - George Ueda
AU  - Cameron M. Chow
AU  - Max Johnson
AU  - Amin Addetia
AU  - Mary-Jane Navarro
AU  - Nuttada Panpradist
AU  - Michael Gale
AU  - Benjamin S. Freedman
AU  - Jesse D. Bloom
AU  - Hannele Ruohola-Baker
AU  - Sean P. J. Whelan
AU  - Lance Stewart
AU  - Michael S. Diamond
AU  - David Veesler
AU  - Michael C. Jewett
AU  - David Baker
PY  - 2022
JO  - Science Translational Medicine
DO  - 10.1126/scitranslmed.abn1252
UR  - https://doi.org/10.1126/scitranslmed.abn1252
ER  -

APA

Hunt, A. C., Case, J. B., Park, Y., Cao, L., Wu, K., Walls, A. C., Liu, Z., Bowen, J. E., Yeh, H., Saini, S., Helms, L., Zhao, Y. T., Hsiang, T., Starr, T. N., Goreshnik, I., Kozodoy, L., Carter, L., Ravichandran, R., Green, L. B., Matochko, W. L., Thomson, C. A., Vögeli, B., Krüger, A., VanBlargan, L. A., Chen, R. E., Ying, B., Bailey, A. L., Kafai, N. M., Boyken, S. E., Ljubetič, A., Edman, N., Ueda, G., Chow, C. M., Johnson, M., Addetia, A., Navarro, M., Panpradist, N., Gale, M., Freedman, B. S., Bloom, J. D., Ruohola-Baker, H., Whelan, S. P. J., Stewart, L., Diamond, M. S., Veesler, D., Jewett, M. C., & Baker, D. (2022). Multivalent designed proteins neutralize SARS-CoV-2 variants of concern and confer protection against infection in mice. Science Translational Medicine. https://doi.org/10.1126/scitranslmed.abn1252

Source records

crossref · retrieved 2026-09-26T19:40:56.766Z